Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CHP1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CHP1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CHP1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CHP1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CHP1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CHP1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CHP1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00019333 | Colorectum | MSI-H | negative regulation of protein phosphorylation | 40/1319 | 342/18723 | 1.11e-03 | 1.86e-02 | 40 |
GO:00066063 | Colorectum | MSI-H | protein import into nucleus | 22/1319 | 155/18723 | 1.28e-03 | 2.03e-02 | 22 |
GO:19045893 | Colorectum | MSI-H | regulation of protein import | 12/1319 | 63/18723 | 1.32e-03 | 2.07e-02 | 12 |
GO:00901503 | Colorectum | MSI-H | establishment of protein localization to membrane | 32/1319 | 260/18723 | 1.47e-03 | 2.23e-02 | 32 |
GO:00020283 | Colorectum | MSI-H | regulation of sodium ion transport | 15/1319 | 90/18723 | 1.48e-03 | 2.23e-02 | 15 |
GO:00709973 | Colorectum | MSI-H | neuron death | 41/1319 | 361/18723 | 1.70e-03 | 2.48e-02 | 41 |
GO:19012143 | Colorectum | MSI-H | regulation of neuron death | 37/1319 | 319/18723 | 1.93e-03 | 2.76e-02 | 37 |
GO:20006493 | Colorectum | MSI-H | regulation of sodium ion transmembrane transporter activity | 11/1319 | 58/18723 | 2.15e-03 | 2.92e-02 | 11 |
GO:00107653 | Colorectum | MSI-H | positive regulation of sodium ion transport | 8/1319 | 35/18723 | 2.52e-03 | 3.33e-02 | 8 |
GO:19023053 | Colorectum | MSI-H | regulation of sodium ion transmembrane transport | 12/1319 | 68/18723 | 2.60e-03 | 3.41e-02 | 12 |
GO:19023073 | Colorectum | MSI-H | positive regulation of sodium ion transmembrane transport | 6/1319 | 21/18723 | 2.61e-03 | 3.41e-02 | 6 |
GO:00423063 | Colorectum | MSI-H | regulation of protein import into nucleus | 11/1319 | 60/18723 | 2.84e-03 | 3.63e-02 | 11 |
GO:20006513 | Colorectum | MSI-H | positive regulation of sodium ion transmembrane transporter activity | 5/1319 | 16/18723 | 3.90e-03 | 4.51e-02 | 5 |
GO:19054753 | Colorectum | FAP | regulation of protein localization to membrane | 58/2622 | 175/18723 | 9.05e-11 | 2.92e-08 | 58 |
GO:19038294 | Colorectum | FAP | positive regulation of cellular protein localization | 79/2622 | 276/18723 | 1.59e-10 | 4.38e-08 | 79 |
GO:00516563 | Colorectum | FAP | establishment of organelle localization | 97/2622 | 390/18723 | 5.91e-09 | 9.48e-07 | 97 |
GO:19049514 | Colorectum | FAP | positive regulation of establishment of protein localization | 82/2622 | 319/18723 | 1.83e-08 | 1.87e-06 | 82 |
GO:00512224 | Colorectum | FAP | positive regulation of protein transport | 78/2622 | 303/18723 | 3.79e-08 | 3.23e-06 | 78 |
GO:19054773 | Colorectum | FAP | positive regulation of protein localization to membrane | 37/2622 | 106/18723 | 4.79e-08 | 3.86e-06 | 37 |
GO:00069134 | Colorectum | FAP | nucleocytoplasmic transport | 77/2622 | 301/18723 | 6.15e-08 | 4.54e-06 | 77 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHP1 | SNV | Missense_Mutation | rs79101281 | c.466N>A | p.Ala156Thr | p.A156T | Q99653 | protein_coding | tolerated(0.18) | benign(0.025) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHP1 | deletion | Frame_Shift_Del | novel | c.298delN | p.Asp101MetfsTer2 | p.D101Mfs*2 | Q99653 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
CHP1 | SNV | Missense_Mutation | | c.73N>T | p.His25Tyr | p.H25Y | Q99653 | protein_coding | deleterious(0.04) | benign(0.068) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CHP1 | SNV | Missense_Mutation | novel | c.280N>A | p.Glu94Lys | p.E94K | Q99653 | protein_coding | tolerated(0.58) | benign(0.001) | TCGA-ZJ-AAXT-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
CHP1 | SNV | Missense_Mutation | rs767999244 | c.254G>A | p.Arg85Gln | p.R85Q | Q99653 | protein_coding | tolerated(0.09) | benign(0.154) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
CHP1 | SNV | Missense_Mutation | rs770704424 | c.419G>A | p.Arg140His | p.R140H | Q99653 | protein_coding | tolerated(0.32) | benign(0.006) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
CHP1 | SNV | Missense_Mutation | novel | c.580N>A | p.Leu194Ile | p.L194I | Q99653 | protein_coding | deleterious(0.02) | probably_damaging(0.966) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CHP1 | SNV | Missense_Mutation | | c.329G>A | p.Ser110Asn | p.S110N | Q99653 | protein_coding | tolerated(0.09) | benign(0.007) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHP1 | SNV | Missense_Mutation | novel | c.580N>A | p.Leu194Ile | p.L194I | Q99653 | protein_coding | deleterious(0.02) | probably_damaging(0.966) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
CHP1 | SNV | Missense_Mutation | | c.292N>G | p.Lys98Glu | p.K98E | Q99653 | protein_coding | tolerated(0.35) | benign(0) | TCGA-BS-A0UJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |