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Gene: CHMP5 |
Gene summary for CHMP5 |
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Gene information | Species | Human | Gene symbol | CHMP5 | Gene ID | 51510 |
Gene name | charged multivesicular body protein 5 | |
Gene Alias | C9orf83 | |
Cytomap | 9p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q9NZZ3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51510 | CHMP5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.63e-02 | 2.86e-01 | -0.0811 |
51510 | CHMP5 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.69e-02 | 1.58e-01 | -0.1088 |
51510 | CHMP5 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.58e-06 | 3.17e-01 | -0.1954 |
51510 | CHMP5 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.44e-03 | 2.42e-01 | -0.1526 |
51510 | CHMP5 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.32e-02 | 1.49e-01 | -0.1464 |
51510 | CHMP5 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.45e-03 | 1.74e-01 | -0.059 |
51510 | CHMP5 | HTA11_5212_2000001011 | Human | Colorectum | AD | 9.39e-03 | 4.45e-01 | -0.2061 |
51510 | CHMP5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.47e-09 | 3.67e-01 | 0.294 |
51510 | CHMP5 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.97e-03 | 7.43e-01 | 0.3487 |
51510 | CHMP5 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.21e-07 | 4.41e-01 | 0.281 |
51510 | CHMP5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.25e-05 | 3.33e-01 | 0.3859 |
51510 | CHMP5 | AEH-subject1 | Human | Endometrium | AEH | 6.13e-10 | -3.06e-01 | -0.3059 |
51510 | CHMP5 | AEH-subject2 | Human | Endometrium | AEH | 2.88e-07 | -1.95e-01 | -0.2525 |
51510 | CHMP5 | AEH-subject3 | Human | Endometrium | AEH | 9.07e-13 | -2.38e-01 | -0.2576 |
51510 | CHMP5 | AEH-subject4 | Human | Endometrium | AEH | 1.77e-04 | -1.95e-01 | -0.2657 |
51510 | CHMP5 | AEH-subject5 | Human | Endometrium | AEH | 3.96e-02 | -2.05e-01 | -0.2953 |
51510 | CHMP5 | EEC-subject1 | Human | Endometrium | EEC | 8.78e-17 | -3.63e-01 | -0.2682 |
51510 | CHMP5 | EEC-subject2 | Human | Endometrium | EEC | 2.13e-15 | -3.44e-01 | -0.2607 |
51510 | CHMP5 | EEC-subject3 | Human | Endometrium | EEC | 3.19e-38 | -3.59e-01 | -0.2525 |
51510 | CHMP5 | EEC-subject4 | Human | Endometrium | EEC | 3.09e-05 | 1.14e-02 | -0.2571 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19016733 | Liver | Cirrhotic | regulation of mitotic spindle assembly | 13/4634 | 18/18723 | 3.02e-05 | 3.78e-04 | 13 |
GO:00901693 | Liver | Cirrhotic | regulation of spindle assembly | 16/4634 | 25/18723 | 3.72e-05 | 4.47e-04 | 16 |
GO:19024105 | Liver | Cirrhotic | mitotic cytokinetic process | 15/4634 | 23/18723 | 4.75e-05 | 5.50e-04 | 15 |
GO:00329846 | Liver | Cirrhotic | protein-containing complex disassembly | 82/4634 | 224/18723 | 4.78e-05 | 5.54e-04 | 82 |
GO:00467553 | Liver | Cirrhotic | viral budding | 16/4634 | 26/18723 | 7.45e-05 | 8.29e-04 | 16 |
GO:0032511 | Liver | Cirrhotic | late endosome to vacuole transport via multivesicular body sorting pathway | 12/4634 | 17/18723 | 8.92e-05 | 9.59e-04 | 12 |
GO:00619522 | Liver | Cirrhotic | midbody abscission | 12/4634 | 17/18723 | 8.92e-05 | 9.59e-04 | 12 |
GO:00325063 | Liver | Cirrhotic | cytokinetic process | 21/4634 | 39/18723 | 9.13e-05 | 9.74e-04 | 21 |
GO:00002812 | Liver | Cirrhotic | mitotic cytokinesis | 32/4634 | 71/18723 | 1.48e-04 | 1.42e-03 | 32 |
GO:005165611 | Liver | Cirrhotic | establishment of organelle localization | 128/4634 | 390/18723 | 1.78e-04 | 1.67e-03 | 128 |
GO:01400142 | Liver | Cirrhotic | mitotic nuclear division | 97/4634 | 287/18723 | 3.32e-04 | 2.87e-03 | 97 |
GO:00602362 | Liver | Cirrhotic | regulation of mitotic spindle organization | 18/4634 | 35/18723 | 6.04e-04 | 4.67e-03 | 18 |
GO:00070522 | Liver | Cirrhotic | mitotic spindle organization | 46/4634 | 120/18723 | 6.56e-04 | 4.98e-03 | 46 |
GO:1902115 | Liver | Cirrhotic | regulation of organelle assembly | 66/4634 | 186/18723 | 6.66e-04 | 5.04e-03 | 66 |
GO:00009105 | Liver | Cirrhotic | cytokinesis | 62/4634 | 173/18723 | 7.13e-04 | 5.33e-03 | 62 |
GO:00324966 | Liver | Cirrhotic | response to lipopolysaccharide | 111/4634 | 343/18723 | 8.15e-04 | 5.95e-03 | 111 |
GO:00902242 | Liver | Cirrhotic | regulation of spindle organization | 19/4634 | 39/18723 | 1.01e-03 | 7.13e-03 | 19 |
GO:004311211 | Liver | Cirrhotic | receptor metabolic process | 59/4634 | 166/18723 | 1.19e-03 | 8.07e-03 | 59 |
GO:0008333 | Liver | Cirrhotic | endosome to lysosome transport | 24/4634 | 55/18723 | 1.67e-03 | 1.07e-02 | 24 |
GO:00903073 | Liver | Cirrhotic | mitotic spindle assembly | 27/4634 | 65/18723 | 2.14e-03 | 1.32e-02 | 27 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa04217 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa042171 | Colorectum | SER | Necroptosis | 47/1580 | 159/8465 | 5.21e-04 | 4.44e-03 | 3.22e-03 | 47 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa0414420 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa04144110 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa0414424 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa0414434 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414422 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414432 | Liver | HCC | Endocytosis | 178/4020 | 251/8465 | 2.03e-14 | 5.22e-13 | 2.91e-13 | 178 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHMP5 | SNV | Missense_Mutation | c.107N>G | p.Ser36Cys | p.S36C | Q9NZZ3 | protein_coding | deleterious(0.02) | possibly_damaging(0.676) | TCGA-A2-A0CL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
CHMP5 | SNV | Missense_Mutation | c.80G>C | p.Arg27Thr | p.R27T | Q9NZZ3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
CHMP5 | SNV | Missense_Mutation | novel | c.261C>A | p.Phe87Leu | p.F87L | Q9NZZ3 | protein_coding | deleterious(0) | benign(0.35) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CHMP5 | SNV | Missense_Mutation | rs758726437 | c.376N>A | p.Asp126Asn | p.D126N | Q9NZZ3 | protein_coding | tolerated(0.13) | benign(0.08) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CHMP5 | SNV | Missense_Mutation | c.138N>T | p.Lys46Asn | p.K46N | Q9NZZ3 | protein_coding | deleterious(0) | possibly_damaging(0.547) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CHMP5 | SNV | Missense_Mutation | rs758726437 | c.376N>A | p.Asp126Asn | p.D126N | Q9NZZ3 | protein_coding | tolerated(0.13) | benign(0.08) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CHMP5 | SNV | Missense_Mutation | c.551N>G | p.Asp184Gly | p.D184G | Q9NZZ3 | protein_coding | tolerated(0.12) | benign(0.137) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHMP5 | SNV | Missense_Mutation | novel | c.433N>G | p.Ile145Val | p.I145V | Q9NZZ3 | protein_coding | tolerated(0.39) | benign(0.019) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
CHMP5 | SNV | Missense_Mutation | novel | c.343N>A | p.Glu115Lys | p.E115K | Q9NZZ3 | protein_coding | deleterious(0.01) | benign(0.41) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
CHMP5 | SNV | Missense_Mutation | c.337N>T | p.Val113Leu | p.V113L | Q9NZZ3 | protein_coding | tolerated(0.4) | benign(0.001) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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