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Gene: BMP7 |
Gene summary for BMP7 |
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Gene information | Species | Human | Gene symbol | BMP7 | Gene ID | 655 |
Gene name | bone morphogenetic protein 7 | |
Gene Alias | OP-1 | |
Cytomap | 20q13.31 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A8K571 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
655 | BMP7 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.45e-03 | 1.99e-01 | 0.0528 |
655 | BMP7 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.40e-09 | 1.80e-01 | 0.294 |
655 | BMP7 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.02e-55 | 1.15e+00 | 0.3859 |
655 | BMP7 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.69e-51 | 7.99e-01 | 0.3005 |
655 | BMP7 | A001-C-119 | Human | Colorectum | FAP | 4.39e-03 | 2.33e-01 | -0.1557 |
655 | BMP7 | A015-C-005 | Human | Colorectum | FAP | 5.50e-03 | 1.91e-01 | -0.0336 |
655 | BMP7 | CRC-1-8810 | Human | Colorectum | CRC | 5.87e-11 | 4.35e-01 | 0.6257 |
655 | BMP7 | CRC-3-11773 | Human | Colorectum | CRC | 5.54e-31 | 7.56e-01 | 0.2564 |
655 | BMP7 | LZE4T | Human | Esophagus | ESCC | 4.78e-06 | 1.59e-01 | 0.0811 |
655 | BMP7 | LZE7T | Human | Esophagus | ESCC | 1.80e-04 | 4.93e-01 | 0.0667 |
655 | BMP7 | LZE8T | Human | Esophagus | ESCC | 4.93e-02 | 4.86e-03 | 0.067 |
655 | BMP7 | LZE22D1 | Human | Esophagus | HGIN | 4.82e-03 | 1.34e-01 | 0.0595 |
655 | BMP7 | LZE22T | Human | Esophagus | ESCC | 7.19e-03 | 2.23e-01 | 0.068 |
655 | BMP7 | LZE24T | Human | Esophagus | ESCC | 7.78e-05 | 3.05e-01 | 0.0596 |
655 | BMP7 | LZE21T | Human | Esophagus | ESCC | 1.29e-06 | 2.89e-01 | 0.0655 |
655 | BMP7 | P2T-E | Human | Esophagus | ESCC | 4.50e-38 | 9.78e-01 | 0.1177 |
655 | BMP7 | P4T-E | Human | Esophagus | ESCC | 8.17e-30 | 9.66e-01 | 0.1323 |
655 | BMP7 | P5T-E | Human | Esophagus | ESCC | 8.35e-12 | 3.30e-01 | 0.1327 |
655 | BMP7 | P8T-E | Human | Esophagus | ESCC | 1.34e-11 | 6.83e-03 | 0.0889 |
655 | BMP7 | P9T-E | Human | Esophagus | ESCC | 2.35e-15 | 2.90e-01 | 0.1131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00346144 | Colorectum | FAP | cellular response to reactive oxygen species | 34/2622 | 155/18723 | 4.68e-03 | 3.16e-02 | 34 |
GO:0060411 | Colorectum | FAP | cardiac septum morphogenesis | 18/2622 | 68/18723 | 4.83e-03 | 3.25e-02 | 18 |
GO:00485682 | Colorectum | FAP | embryonic organ development | 79/2622 | 427/18723 | 5.32e-03 | 3.49e-02 | 79 |
GO:00519611 | Colorectum | FAP | negative regulation of nervous system development | 32/2622 | 145/18723 | 5.41e-03 | 3.53e-02 | 32 |
GO:00104631 | Colorectum | FAP | mesenchymal cell proliferation | 12/2622 | 39/18723 | 5.54e-03 | 3.59e-02 | 12 |
GO:0016331 | Colorectum | FAP | morphogenesis of embryonic epithelium | 32/2622 | 147/18723 | 6.69e-03 | 4.13e-02 | 32 |
GO:0034114 | Colorectum | FAP | regulation of heterotypic cell-cell adhesion | 9/2622 | 26/18723 | 6.73e-03 | 4.14e-02 | 9 |
GO:00510901 | Colorectum | FAP | regulation of DNA-binding transcription factor activity | 80/2622 | 440/18723 | 7.90e-03 | 4.67e-02 | 80 |
GO:0003205 | Colorectum | FAP | cardiac chamber development | 34/2622 | 161/18723 | 8.57e-03 | 4.96e-02 | 34 |
GO:0003206 | Colorectum | FAP | cardiac chamber morphogenesis | 27/2622 | 121/18723 | 8.64e-03 | 4.98e-02 | 27 |
GO:00487325 | Colorectum | CRC | gland development | 88/2078 | 436/18723 | 1.62e-08 | 2.79e-06 | 88 |
GO:00713834 | Colorectum | CRC | cellular response to steroid hormone stimulus | 51/2078 | 204/18723 | 1.67e-08 | 2.79e-06 | 51 |
GO:00434015 | Colorectum | CRC | steroid hormone mediated signaling pathway | 37/2078 | 136/18723 | 1.52e-07 | 1.66e-05 | 37 |
GO:00097555 | Colorectum | CRC | hormone-mediated signaling pathway | 46/2078 | 190/18723 | 2.28e-07 | 2.27e-05 | 46 |
GO:00074094 | Colorectum | CRC | axonogenesis | 81/2078 | 418/18723 | 3.60e-07 | 2.99e-05 | 81 |
GO:00615644 | Colorectum | CRC | axon development | 86/2078 | 467/18723 | 1.48e-06 | 8.12e-05 | 86 |
GO:00485455 | Colorectum | CRC | response to steroid hormone | 67/2078 | 339/18723 | 1.77e-06 | 8.92e-05 | 67 |
GO:00457855 | Colorectum | CRC | positive regulation of cell adhesion | 81/2078 | 437/18723 | 2.28e-06 | 1.10e-04 | 81 |
GO:00109754 | Colorectum | CRC | regulation of neuron projection development | 82/2078 | 445/18723 | 2.51e-06 | 1.19e-04 | 82 |
GO:00720733 | Colorectum | CRC | kidney epithelium development | 34/2078 | 136/18723 | 3.87e-06 | 1.63e-04 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04350 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa043501 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043602 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa043603 | Colorectum | MSS | Axon guidance | 54/1875 | 182/8465 | 1.03e-02 | 3.69e-02 | 2.26e-02 | 54 |
hsa043604 | Colorectum | FAP | Axon guidance | 47/1404 | 182/8465 | 9.09e-04 | 5.20e-03 | 3.16e-03 | 47 |
hsa043902 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa043605 | Colorectum | FAP | Axon guidance | 47/1404 | 182/8465 | 9.09e-04 | 5.20e-03 | 3.16e-03 | 47 |
hsa043903 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa043606 | Colorectum | CRC | Axon guidance | 43/1091 | 182/8465 | 4.38e-05 | 8.70e-04 | 5.90e-04 | 43 |
hsa043904 | Colorectum | CRC | Hippo signaling pathway | 32/1091 | 157/8465 | 5.17e-03 | 2.72e-02 | 1.84e-02 | 32 |
hsa043607 | Colorectum | CRC | Axon guidance | 43/1091 | 182/8465 | 4.38e-05 | 8.70e-04 | 5.90e-04 | 43 |
hsa043905 | Colorectum | CRC | Hippo signaling pathway | 32/1091 | 157/8465 | 5.17e-03 | 2.72e-02 | 1.84e-02 | 32 |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0436016 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0439018 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
hsa0435014 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa0436017 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0439019 | Esophagus | ESCC | Hippo signaling pathway | 92/4205 | 157/8465 | 1.46e-02 | 3.31e-02 | 1.69e-02 | 92 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
BMP7 | ACVR1_ACVR2A | BMP7_ACVR1_ACVR2A | BMP | Cervix | CC |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | Cervix | CC |
BMP7 | BMPR1A_ACVR2A | BMP7_BMPR1A_ACVR2A | BMP | Cervix | CC |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | Cervix | CC |
BMP7 | BMPR1B_ACVR2A | BMP7_BMPR1B_ACVR2A | BMP | Cervix | CC |
BMP7 | BMPR1B_BMPR2 | BMP7_BMPR1B_BMPR2 | BMP | Cervix | CC |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | Endometrium | AEH |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | Endometrium | AEH |
BMP7 | BMPR1B_BMPR2 | BMP7_BMPR1B_BMPR2 | BMP | Endometrium | AEH |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | Esophagus | ESCC |
BMP7 | BMPR1A_ACVR2B | BMP7_BMPR1A_ACVR2B | BMP | Esophagus | ESCC |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | HNSCC | OSCC |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | HNSCC | Precancer |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | HNSCC | Precancer |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | THCA | ADJ |
BMP7 | BMPR1A_ACVR2A | BMP7_BMPR1A_ACVR2A | BMP | THCA | ADJ |
BMP7 | BMPR1A_BMPR2 | BMP7_BMPR1A_BMPR2 | BMP | THCA | ADJ |
BMP7 | ACVR1_BMPR2 | BMP7_ACVR1_BMPR2 | BMP | THCA | PTC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BMP7 | insertion | In_Frame_Ins | novel | c.868_869insAACCAAAGCTTCAAATAATGAACCTCACAACAAACCATT | p.Ser290delinsLysProLysLeuGlnIleMetAsnLeuThrThrAsnHisCys | p.S290delinsKPKLQIMNLTTNHC | P18075 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BMP7 | insertion | Frame_Shift_Ins | novel | c.1044_1045insT | p.Ile349TyrfsTer4 | p.I349Yfs*4 | P18075 | protein_coding | TCGA-BH-A0GY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyotxan | SD | ||
BMP7 | deletion | Frame_Shift_Del | novel | c.237delN | p.Met81CysfsTer54 | p.M81Cfs*54 | P18075 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
BMP7 | SNV | Missense_Mutation | rs201575559 | c.449N>A | p.Arg150His | p.R150H | P18075 | protein_coding | deleterious(0.04) | benign(0.013) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BMP7 | SNV | Missense_Mutation | c.517N>A | p.Glu173Lys | p.E173K | P18075 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BMP7 | SNV | Missense_Mutation | novel | c.1290N>G | p.Cys430Trp | p.C430W | P18075 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3850-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
BMP7 | SNV | Missense_Mutation | c.517N>A | p.Glu173Lys | p.E173K | P18075 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BMP7 | SNV | Missense_Mutation | c.391N>A | p.Asp131Asn | p.D131N | P18075 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BMP7 | SNV | Missense_Mutation | rs149261355 | c.556G>A | p.Asp186Asn | p.D186N | P18075 | protein_coding | tolerated(0.43) | benign(0.015) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
BMP7 | SNV | Missense_Mutation | rs772689429 | c.1000G>A | p.Glu334Lys | p.E334K | P18075 | protein_coding | deleterious(0) | benign(0.325) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | pegaspargase | PEGASPARGASE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | methotrexate | METHOTREXATE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | cyclophosphamide | CYCLOPHOSPHAMIDE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | thioguanine | THIOGUANINE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | prednisone | PREDNISONE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | dexamethasone | DEXAMETHASONE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | cytarabine | CYTARABINE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | vincristine | VINCRISTINE | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | daunorubicin | DAUNORUBICIN | 26590194 | |
655 | BMP7 | TRANSCRIPTION FACTOR, DRUGGABLE GENOME, GROWTH FACTOR | doxorubicin | DOXORUBICIN | 26590194 |
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