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Gene: BMI1 |
Gene summary for BMI1 |
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Gene information | Species | Human | Gene symbol | BMI1 | Gene ID | 648 |
Gene name | BMI1 proto-oncogene, polycomb ring finger | |
Gene Alias | FLVI2/BMI1 | |
Cytomap | 10p12.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P35226 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
648 | BMI1 | LZE4T | Human | Esophagus | ESCC | 8.45e-07 | 9.32e-02 | 0.0811 |
648 | BMI1 | LZE8T | Human | Esophagus | ESCC | 2.56e-07 | 8.89e-02 | 0.067 |
648 | BMI1 | LZE22T | Human | Esophagus | ESCC | 2.37e-05 | 1.91e-01 | 0.068 |
648 | BMI1 | LZE24T | Human | Esophagus | ESCC | 2.83e-14 | 4.93e-01 | 0.0596 |
648 | BMI1 | P1T-E | Human | Esophagus | ESCC | 2.93e-03 | 2.59e-01 | 0.0875 |
648 | BMI1 | P2T-E | Human | Esophagus | ESCC | 1.17e-17 | 3.98e-01 | 0.1177 |
648 | BMI1 | P4T-E | Human | Esophagus | ESCC | 3.80e-16 | 2.39e-01 | 0.1323 |
648 | BMI1 | P5T-E | Human | Esophagus | ESCC | 3.96e-10 | 1.42e-01 | 0.1327 |
648 | BMI1 | P8T-E | Human | Esophagus | ESCC | 4.12e-22 | 3.41e-01 | 0.0889 |
648 | BMI1 | P9T-E | Human | Esophagus | ESCC | 4.34e-07 | 7.97e-02 | 0.1131 |
648 | BMI1 | P10T-E | Human | Esophagus | ESCC | 9.97e-13 | 1.59e-01 | 0.116 |
648 | BMI1 | P11T-E | Human | Esophagus | ESCC | 3.35e-06 | 2.46e-01 | 0.1426 |
648 | BMI1 | P12T-E | Human | Esophagus | ESCC | 3.40e-20 | 2.80e-01 | 0.1122 |
648 | BMI1 | P15T-E | Human | Esophagus | ESCC | 3.29e-11 | 1.41e-01 | 0.1149 |
648 | BMI1 | P16T-E | Human | Esophagus | ESCC | 6.55e-09 | 1.35e-01 | 0.1153 |
648 | BMI1 | P17T-E | Human | Esophagus | ESCC | 1.67e-04 | 1.17e-01 | 0.1278 |
648 | BMI1 | P20T-E | Human | Esophagus | ESCC | 4.07e-13 | 2.07e-01 | 0.1124 |
648 | BMI1 | P21T-E | Human | Esophagus | ESCC | 1.59e-11 | 3.09e-01 | 0.1617 |
648 | BMI1 | P22T-E | Human | Esophagus | ESCC | 1.15e-12 | 1.44e-01 | 0.1236 |
648 | BMI1 | P23T-E | Human | Esophagus | ESCC | 1.38e-13 | 3.36e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000651314 | Thyroid | ATC | protein monoubiquitination | 35/6293 | 67/18723 | 1.26e-03 | 6.58e-03 | 35 |
GO:004341412 | Thyroid | ATC | macromolecule methylation | 131/6293 | 316/18723 | 2.01e-03 | 9.60e-03 | 131 |
GO:00485688 | Thyroid | ATC | embryonic organ development | 172/6293 | 427/18723 | 2.08e-03 | 9.84e-03 | 172 |
GO:00458141 | Thyroid | ATC | negative regulation of gene expression, epigenetic | 27/6293 | 50/18723 | 2.35e-03 | 1.10e-02 | 27 |
GO:003225911 | Thyroid | ATC | methylation | 148/6293 | 364/18723 | 2.69e-03 | 1.23e-02 | 148 |
GO:005138427 | Thyroid | ATC | response to glucocorticoid | 65/6293 | 148/18723 | 5.62e-03 | 2.28e-02 | 65 |
GO:007055513 | Thyroid | ATC | response to interleukin-1 | 63/6293 | 143/18723 | 5.82e-03 | 2.35e-02 | 63 |
GO:003196027 | Thyroid | ATC | response to corticosteroid | 72/6293 | 167/18723 | 6.39e-03 | 2.55e-02 | 72 |
GO:00103905 | Thyroid | ATC | histone monoubiquitination | 16/6293 | 29/18723 | 1.37e-02 | 4.77e-02 | 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520221 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
hsa0520231 | Prostate | Tumor | Transcriptional misregulation in cancer | 59/1791 | 193/8465 | 1.22e-03 | 5.26e-03 | 3.26e-03 | 59 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BMI1 | SNV | Missense_Mutation | c.229G>C | p.Asp77His | p.D77H | P35226 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
BMI1 | SNV | Missense_Mutation | c.133N>T | p.Arg45Cys | p.R45C | P35226 | protein_coding | deleterious(0.02) | probably_damaging(0.967) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BMI1 | SNV | Missense_Mutation | c.742G>A | p.Glu248Lys | p.E248K | P35226 | protein_coding | tolerated(0.4) | benign(0.021) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
BMI1 | SNV | Missense_Mutation | c.337N>C | p.Asp113His | p.D113H | P35226 | protein_coding | deleterious(0) | benign(0.184) | TCGA-FU-A3HY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
BMI1 | SNV | Missense_Mutation | c.847N>T | p.His283Tyr | p.H283Y | P35226 | protein_coding | deleterious_low_confidence(0.03) | benign(0.139) | TCGA-IR-A3LI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
BMI1 | SNV | Missense_Mutation | novel | c.371N>G | p.Ile124Ser | p.I124S | P35226 | protein_coding | tolerated(0.07) | benign(0.186) | TCGA-VS-A8QF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BMI1 | SNV | Missense_Mutation | c.98N>T | p.Glu33Val | p.E33V | P35226 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
BMI1 | SNV | Missense_Mutation | c.14N>T | p.Thr5Met | p.T5M | P35226 | protein_coding | tolerated(0.07) | benign(0.406) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
BMI1 | SNV | Missense_Mutation | c.221N>G | p.Thr74Ser | p.T74S | P35226 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-AA-3866-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BMI1 | SNV | Missense_Mutation | rs530837837 | c.433C>T | p.Arg145Trp | p.R145W | P35226 | protein_coding | deleterious(0.01) | possibly_damaging(0.776) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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