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Gene: BECN1 |
Gene summary for BECN1 |
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Gene information | Species | Human | Gene symbol | BECN1 | Gene ID | 8678 |
Gene name | beclin 1 | |
Gene Alias | ATG6 | |
Cytomap | 17q21.31 | |
Gene Type | protein-coding | GO ID | GO:0000045 | UniProtAcc | A0A024R1X5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8678 | BECN1 | LZE4T | Human | Esophagus | ESCC | 2.03e-08 | 2.94e-01 | 0.0811 |
8678 | BECN1 | LZE7T | Human | Esophagus | ESCC | 3.24e-10 | 5.86e-01 | 0.0667 |
8678 | BECN1 | LZE8T | Human | Esophagus | ESCC | 1.75e-09 | 2.27e-01 | 0.067 |
8678 | BECN1 | LZE20T | Human | Esophagus | ESCC | 1.98e-03 | 1.63e-01 | 0.0662 |
8678 | BECN1 | LZE24T | Human | Esophagus | ESCC | 2.30e-30 | 9.65e-01 | 0.0596 |
8678 | BECN1 | LZE21T | Human | Esophagus | ESCC | 6.12e-04 | 2.61e-01 | 0.0655 |
8678 | BECN1 | LZE6T | Human | Esophagus | ESCC | 3.59e-05 | 3.03e-01 | 0.0845 |
8678 | BECN1 | P1T-E | Human | Esophagus | ESCC | 4.93e-04 | 5.49e-01 | 0.0875 |
8678 | BECN1 | P2T-E | Human | Esophagus | ESCC | 1.21e-29 | 4.20e-01 | 0.1177 |
8678 | BECN1 | P4T-E | Human | Esophagus | ESCC | 6.14e-35 | 8.99e-01 | 0.1323 |
8678 | BECN1 | P5T-E | Human | Esophagus | ESCC | 5.00e-20 | 6.06e-01 | 0.1327 |
8678 | BECN1 | P8T-E | Human | Esophagus | ESCC | 6.74e-48 | 1.11e+00 | 0.0889 |
8678 | BECN1 | P9T-E | Human | Esophagus | ESCC | 1.43e-08 | 2.25e-01 | 0.1131 |
8678 | BECN1 | P10T-E | Human | Esophagus | ESCC | 1.89e-23 | 2.03e-01 | 0.116 |
8678 | BECN1 | P11T-E | Human | Esophagus | ESCC | 1.74e-15 | 5.69e-01 | 0.1426 |
8678 | BECN1 | P12T-E | Human | Esophagus | ESCC | 1.29e-33 | 5.65e-01 | 0.1122 |
8678 | BECN1 | P15T-E | Human | Esophagus | ESCC | 5.09e-24 | 6.88e-01 | 0.1149 |
8678 | BECN1 | P16T-E | Human | Esophagus | ESCC | 3.45e-18 | 4.26e-01 | 0.1153 |
8678 | BECN1 | P17T-E | Human | Esophagus | ESCC | 6.97e-05 | 2.81e-01 | 0.1278 |
8678 | BECN1 | P19T-E | Human | Esophagus | ESCC | 8.99e-08 | 5.33e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0007080 | Liver | HCC | mitotic metaphase plate congression | 36/7958 | 50/18723 | 2.28e-05 | 2.41e-04 | 36 |
GO:004532411 | Liver | HCC | late endosome to vacuole transport | 21/7958 | 25/18723 | 2.47e-05 | 2.58e-04 | 21 |
GO:00440881 | Liver | HCC | regulation of vacuole organization | 33/7958 | 45/18723 | 2.69e-05 | 2.79e-04 | 33 |
GO:0098780 | Liver | HCC | response to mitochondrial depolarisation | 17/7958 | 19/18723 | 2.93e-05 | 3.03e-04 | 17 |
GO:004502211 | Liver | HCC | early endosome to late endosome transport | 30/7958 | 40/18723 | 3.04e-05 | 3.12e-04 | 30 |
GO:200037722 | Liver | HCC | regulation of reactive oxygen species metabolic process | 92/7958 | 157/18723 | 3.34e-05 | 3.35e-04 | 92 |
GO:000091011 | Liver | HCC | cytokinesis | 100/7958 | 173/18723 | 3.38e-05 | 3.39e-04 | 100 |
GO:004311221 | Liver | HCC | receptor metabolic process | 96/7958 | 166/18723 | 4.69e-05 | 4.50e-04 | 96 |
GO:0051983 | Liver | HCC | regulation of chromosome segregation | 57/7958 | 91/18723 | 8.35e-05 | 7.36e-04 | 57 |
GO:000042311 | Liver | HCC | mitophagy | 22/7958 | 28/18723 | 1.10e-04 | 9.41e-04 | 22 |
GO:0033045 | Liver | HCC | regulation of sister chromatid segregation | 46/7958 | 72/18723 | 2.02e-04 | 1.56e-03 | 46 |
GO:20007851 | Liver | HCC | regulation of autophagosome assembly | 28/7958 | 39/18723 | 2.02e-04 | 1.56e-03 | 28 |
GO:00070401 | Liver | HCC | lysosome organization | 47/7958 | 74/18723 | 2.13e-04 | 1.63e-03 | 47 |
GO:00801711 | Liver | HCC | lytic vacuole organization | 47/7958 | 74/18723 | 2.13e-04 | 1.63e-03 | 47 |
GO:0016242 | Liver | HCC | negative regulation of macroautophagy | 25/7958 | 34/18723 | 2.42e-04 | 1.81e-03 | 25 |
GO:0016239 | Liver | HCC | positive regulation of macroautophagy | 41/7958 | 63/18723 | 2.47e-04 | 1.84e-03 | 41 |
GO:0051310 | Liver | HCC | metaphase plate congression | 42/7958 | 65/18723 | 2.63e-04 | 1.94e-03 | 42 |
GO:200124421 | Liver | HCC | positive regulation of intrinsic apoptotic signaling pathway | 38/7958 | 58/18723 | 3.37e-04 | 2.36e-03 | 38 |
GO:19909281 | Liver | HCC | response to amino acid starvation | 33/7958 | 49/18723 | 3.86e-04 | 2.62e-03 | 33 |
GO:0033047 | Liver | HCC | regulation of mitotic sister chromatid segregation | 31/7958 | 46/18723 | 5.67e-04 | 3.61e-03 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa05016210 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa05022210 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa05010210 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa05131211 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa05167211 | Esophagus | ESCC | Kaposi sarcoma-associated herpesvirus infection | 136/4205 | 194/8465 | 4.28e-09 | 4.22e-08 | 2.16e-08 | 136 |
hsa0414010 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa04137210 | Esophagus | ESCC | Mitophagy - animal | 54/4205 | 72/8465 | 9.33e-06 | 4.96e-05 | 2.54e-05 | 54 |
hsa0501728 | Esophagus | ESCC | Spinocerebellar ataxia | 94/4205 | 143/8465 | 6.77e-05 | 2.90e-04 | 1.48e-04 | 94 |
hsa042156 | Esophagus | ESCC | Apoptosis - multiple species | 25/4205 | 32/8465 | 9.13e-04 | 2.92e-03 | 1.49e-03 | 25 |
hsa041362 | Esophagus | ESCC | Autophagy - other | 23/4205 | 32/8465 | 8.99e-03 | 2.14e-02 | 1.09e-02 | 23 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0501638 | Esophagus | ESCC | Huntington disease | 226/4205 | 306/8465 | 1.38e-18 | 8.72e-17 | 4.46e-17 | 226 |
hsa0502238 | Esophagus | ESCC | Pathways of neurodegeneration - multiple diseases | 318/4205 | 476/8465 | 6.10e-15 | 2.04e-13 | 1.05e-13 | 318 |
hsa0501038 | Esophagus | ESCC | Alzheimer disease | 263/4205 | 384/8465 | 1.80e-14 | 5.47e-13 | 2.80e-13 | 263 |
hsa05131310 | Esophagus | ESCC | Shigellosis | 176/4205 | 247/8465 | 2.27e-12 | 4.01e-11 | 2.05e-11 | 176 |
hsa0516738 | Esophagus | ESCC | Kaposi sarcoma-associated herpesvirus infection | 136/4205 | 194/8465 | 4.28e-09 | 4.22e-08 | 2.16e-08 | 136 |
hsa0414015 | Esophagus | ESCC | Autophagy - animal | 101/4205 | 141/8465 | 7.60e-08 | 6.21e-07 | 3.18e-07 | 101 |
hsa0413738 | Esophagus | ESCC | Mitophagy - animal | 54/4205 | 72/8465 | 9.33e-06 | 4.96e-05 | 2.54e-05 | 54 |
hsa0501736 | Esophagus | ESCC | Spinocerebellar ataxia | 94/4205 | 143/8465 | 6.77e-05 | 2.90e-04 | 1.48e-04 | 94 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BECN1 | SNV | Missense_Mutation | novel | c.1264G>A | p.Glu422Lys | p.E422K | Q14457 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
BECN1 | SNV | Missense_Mutation | rs748062728 | c.107G>A | p.Arg36His | p.R36H | Q14457 | protein_coding | tolerated(0.07) | benign(0.179) | TCGA-S3-AA17-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrozole | SD |
BECN1 | insertion | Nonsense_Mutation | novel | c.53_54insACCGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGA | p.Cys18delinsTer | p.C18delins* | Q14457 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
BECN1 | deletion | Frame_Shift_Del | novel | c.750delN | p.Glu251LysfsTer14 | p.E251Kfs*14 | Q14457 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
BECN1 | SNV | Missense_Mutation | novel | c.735N>A | p.Asp245Glu | p.D245E | Q14457 | protein_coding | tolerated(0.16) | possibly_damaging(0.657) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
BECN1 | SNV | Missense_Mutation | novel | c.211N>A | p.Glu71Lys | p.E71K | Q14457 | protein_coding | deleterious(0.04) | possibly_damaging(0.495) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
BECN1 | SNV | Missense_Mutation | c.1150G>C | p.Glu384Gln | p.E384Q | Q14457 | protein_coding | deleterious(0.03) | probably_damaging(0.995) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
BECN1 | SNV | Missense_Mutation | novel | c.38N>G | p.Gln13Arg | p.Q13R | Q14457 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-AA-3848-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
BECN1 | SNV | Missense_Mutation | rs759566966 | c.341G>A | p.Arg114Gln | p.R114Q | Q14457 | protein_coding | tolerated(0.69) | benign(0.003) | TCGA-CM-4744-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
BECN1 | insertion | Frame_Shift_Ins | novel | c.254_255insC | p.Ala86SerfsTer20 | p.A86Sfs*20 | Q14457 | protein_coding | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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