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Gene: ATP5PO |
Gene summary for ATP5PO |
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Gene information | Species | Human | Gene symbol | ATP5PO | Gene ID | 539 |
Gene name | ATP synthase peripheral stalk subunit OSCP | |
Gene Alias | ATP5O | |
Cytomap | 21q22.11 | |
Gene Type | protein-coding | GO ID | GO:0006091 | UniProtAcc | P48047 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
539 | ATP5PO | GSM4909281 | Human | Breast | IDC | 4.93e-10 | 5.12e-01 | 0.21 |
539 | ATP5PO | GSM4909282 | Human | Breast | IDC | 6.68e-11 | 5.52e-01 | -0.0288 |
539 | ATP5PO | GSM4909285 | Human | Breast | IDC | 3.60e-66 | 1.08e+00 | 0.21 |
539 | ATP5PO | GSM4909286 | Human | Breast | IDC | 3.38e-21 | 4.71e-01 | 0.1081 |
539 | ATP5PO | GSM4909293 | Human | Breast | IDC | 4.37e-09 | -1.26e-01 | 0.1581 |
539 | ATP5PO | GSM4909294 | Human | Breast | IDC | 3.00e-10 | 5.49e-01 | 0.2022 |
539 | ATP5PO | GSM4909296 | Human | Breast | IDC | 1.10e-05 | 3.67e-01 | 0.1524 |
539 | ATP5PO | GSM4909297 | Human | Breast | IDC | 8.68e-07 | 1.95e-01 | 0.1517 |
539 | ATP5PO | GSM4909298 | Human | Breast | IDC | 1.75e-19 | 5.55e-01 | 0.1551 |
539 | ATP5PO | GSM4909299 | Human | Breast | IDC | 5.66e-04 | 4.06e-01 | 0.035 |
539 | ATP5PO | GSM4909301 | Human | Breast | IDC | 1.04e-03 | 3.97e-01 | 0.1577 |
539 | ATP5PO | GSM4909304 | Human | Breast | IDC | 3.56e-05 | 2.28e-01 | 0.1636 |
539 | ATP5PO | GSM4909305 | Human | Breast | IDC | 2.53e-11 | 4.70e-01 | 0.0436 |
539 | ATP5PO | GSM4909306 | Human | Breast | IDC | 1.85e-11 | 4.44e-01 | 0.1564 |
539 | ATP5PO | GSM4909307 | Human | Breast | IDC | 1.38e-05 | 4.84e-01 | 0.1569 |
539 | ATP5PO | GSM4909308 | Human | Breast | IDC | 1.99e-33 | 7.07e-01 | 0.158 |
539 | ATP5PO | GSM4909311 | Human | Breast | IDC | 1.75e-24 | 7.24e-02 | 0.1534 |
539 | ATP5PO | GSM4909312 | Human | Breast | IDC | 3.21e-07 | 4.94e-01 | 0.1552 |
539 | ATP5PO | GSM4909315 | Human | Breast | IDC | 2.13e-03 | 4.14e-01 | 0.21 |
539 | ATP5PO | GSM4909316 | Human | Breast | IDC | 6.19e-06 | 5.56e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00159851 | Colorectum | SER | energy coupled proton transport, down electrochemical gradient | 17/2897 | 26/18723 | 1.22e-08 | 9.74e-07 | 17 |
GO:00159861 | Colorectum | SER | ATP synthesis coupled proton transport | 17/2897 | 26/18723 | 1.22e-08 | 9.74e-07 | 17 |
GO:00092051 | Colorectum | SER | purine ribonucleoside triphosphate metabolic process | 34/2897 | 82/18723 | 1.37e-08 | 1.05e-06 | 34 |
GO:00067541 | Colorectum | SER | ATP biosynthetic process | 27/2897 | 57/18723 | 1.38e-08 | 1.05e-06 | 27 |
GO:00092061 | Colorectum | SER | purine ribonucleoside triphosphate biosynthetic process | 30/2897 | 68/18723 | 1.74e-08 | 1.28e-06 | 30 |
GO:00427761 | Colorectum | SER | mitochondrial ATP synthesis coupled proton transport | 14/2897 | 19/18723 | 2.35e-08 | 1.68e-06 | 14 |
GO:00091171 | Colorectum | SER | nucleotide metabolic process | 122/2897 | 489/18723 | 2.50e-08 | 1.76e-06 | 122 |
GO:00091411 | Colorectum | SER | nucleoside triphosphate metabolic process | 41/2897 | 112/18723 | 3.46e-08 | 2.31e-06 | 41 |
GO:00067531 | Colorectum | SER | nucleoside phosphate metabolic process | 122/2897 | 497/18723 | 6.64e-08 | 4.33e-06 | 122 |
GO:00091991 | Colorectum | SER | ribonucleoside triphosphate metabolic process | 34/2897 | 89/18723 | 1.52e-07 | 8.81e-06 | 34 |
GO:00092011 | Colorectum | SER | ribonucleoside triphosphate biosynthetic process | 30/2897 | 74/18723 | 1.76e-07 | 9.97e-06 | 30 |
GO:00091421 | Colorectum | SER | nucleoside triphosphate biosynthetic process | 32/2897 | 85/18723 | 5.16e-07 | 2.53e-05 | 32 |
GO:00091521 | Colorectum | SER | purine ribonucleotide biosynthetic process | 48/2897 | 169/18723 | 1.27e-05 | 4.01e-04 | 48 |
GO:00092601 | Colorectum | SER | ribonucleotide biosynthetic process | 49/2897 | 182/18723 | 4.85e-05 | 1.19e-03 | 49 |
GO:00463901 | Colorectum | SER | ribose phosphate biosynthetic process | 50/2897 | 190/18723 | 7.70e-05 | 1.72e-03 | 50 |
GO:00725221 | Colorectum | SER | purine-containing compound biosynthetic process | 51/2897 | 200/18723 | 1.55e-04 | 3.01e-03 | 51 |
GO:00061641 | Colorectum | SER | purine nucleotide biosynthetic process | 49/2897 | 191/18723 | 1.77e-04 | 3.30e-03 | 49 |
GO:00091651 | Colorectum | SER | nucleotide biosynthetic process | 58/2897 | 254/18723 | 1.21e-03 | 1.38e-02 | 58 |
GO:19012931 | Colorectum | SER | nucleoside phosphate biosynthetic process | 58/2897 | 256/18723 | 1.47e-03 | 1.59e-02 | 58 |
GO:004603416 | Endometrium | AEH | ATP metabolic process | 106/2100 | 277/18723 | 4.13e-32 | 1.24e-28 | 106 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502016 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501616 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019016 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501016 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501416 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502216 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520818 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471418 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541518 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0502017 | Breast | Precancer | Prion disease | 95/684 | 273/8465 | 1.39e-37 | 1.46e-35 | 1.12e-35 | 95 |
hsa0501617 | Breast | Precancer | Huntington disease | 98/684 | 306/8465 | 2.85e-35 | 2.25e-33 | 1.72e-33 | 98 |
hsa0019017 | Breast | Precancer | Oxidative phosphorylation | 59/684 | 134/8465 | 6.15e-30 | 3.24e-28 | 2.48e-28 | 59 |
hsa0501017 | Breast | Precancer | Alzheimer disease | 103/684 | 384/8465 | 1.03e-29 | 4.66e-28 | 3.57e-28 | 103 |
hsa0501417 | Breast | Precancer | Amyotrophic lateral sclerosis | 98/684 | 364/8465 | 2.13e-28 | 8.41e-27 | 6.44e-27 | 98 |
hsa0502217 | Breast | Precancer | Pathways of neurodegeneration - multiple diseases | 112/684 | 476/8465 | 6.96e-27 | 2.44e-25 | 1.87e-25 | 112 |
hsa0520819 | Breast | Precancer | Chemical carcinogenesis - reactive oxygen species | 68/684 | 223/8465 | 3.61e-23 | 1.14e-21 | 8.73e-22 | 68 |
hsa0471419 | Breast | Precancer | Thermogenesis | 68/684 | 232/8465 | 4.40e-22 | 1.26e-20 | 9.69e-21 | 68 |
hsa0541519 | Breast | Precancer | Diabetic cardiomyopathy | 63/684 | 203/8465 | 5.63e-22 | 1.48e-20 | 1.14e-20 | 63 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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