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Gene: ARL8B |
Gene summary for ARL8B |
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Gene information | Species | Human | Gene symbol | ARL8B | Gene ID | 55207 |
Gene name | ADP ribosylation factor like GTPase 8B | |
Gene Alias | ARL10C | |
Cytomap | 3p26.1 | |
Gene Type | protein-coding | GO ID | GO:0001778 | UniProtAcc | A0A024R2D4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55207 | ARL8B | CCI_1 | Human | Cervix | CC | 1.98e-02 | 5.86e-01 | 0.528 |
55207 | ARL8B | CCI_2 | Human | Cervix | CC | 3.38e-05 | 8.49e-01 | 0.5249 |
55207 | ARL8B | CCI_3 | Human | Cervix | CC | 2.20e-06 | 9.81e-01 | 0.516 |
55207 | ARL8B | sample3 | Human | Cervix | CC | 4.99e-04 | 1.84e-01 | 0.1387 |
55207 | ARL8B | T3 | Human | Cervix | CC | 9.18e-04 | 2.03e-01 | 0.1389 |
55207 | ARL8B | LZE4T | Human | Esophagus | ESCC | 1.37e-17 | 7.25e-01 | 0.0811 |
55207 | ARL8B | LZE7T | Human | Esophagus | ESCC | 5.00e-03 | 2.78e-01 | 0.0667 |
55207 | ARL8B | LZE8T | Human | Esophagus | ESCC | 7.27e-04 | 4.46e-02 | 0.067 |
55207 | ARL8B | LZE20T | Human | Esophagus | ESCC | 6.17e-07 | 2.10e-01 | 0.0662 |
55207 | ARL8B | LZE24T | Human | Esophagus | ESCC | 3.92e-10 | 3.23e-01 | 0.0596 |
55207 | ARL8B | LZE21T | Human | Esophagus | ESCC | 3.54e-02 | 2.40e-02 | 0.0655 |
55207 | ARL8B | LZE6T | Human | Esophagus | ESCC | 1.16e-02 | 1.09e-01 | 0.0845 |
55207 | ARL8B | P2T-E | Human | Esophagus | ESCC | 1.27e-25 | 1.06e-01 | 0.1177 |
55207 | ARL8B | P4T-E | Human | Esophagus | ESCC | 3.63e-29 | 9.03e-01 | 0.1323 |
55207 | ARL8B | P5T-E | Human | Esophagus | ESCC | 2.37e-68 | 1.63e+00 | 0.1327 |
55207 | ARL8B | P8T-E | Human | Esophagus | ESCC | 7.72e-27 | 1.40e-01 | 0.0889 |
55207 | ARL8B | P9T-E | Human | Esophagus | ESCC | 4.25e-11 | 3.60e-01 | 0.1131 |
55207 | ARL8B | P10T-E | Human | Esophagus | ESCC | 1.46e-16 | 2.92e-01 | 0.116 |
55207 | ARL8B | P11T-E | Human | Esophagus | ESCC | 1.19e-06 | 5.70e-01 | 0.1426 |
55207 | ARL8B | P12T-E | Human | Esophagus | ESCC | 3.38e-24 | 7.13e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00801714 | Skin | cSCC | lytic vacuole organization | 30/4864 | 74/18723 | 4.32e-03 | 2.27e-02 | 30 |
GO:00083334 | Skin | cSCC | endosome to lysosome transport | 23/4864 | 55/18723 | 7.54e-03 | 3.53e-02 | 23 |
GO:001603230 | Thyroid | HT | viral process | 81/1272 | 415/18723 | 3.08e-18 | 2.45e-15 | 81 |
GO:001905830 | Thyroid | HT | viral life cycle | 66/1272 | 317/18723 | 1.54e-16 | 7.81e-14 | 66 |
GO:004440329 | Thyroid | HT | biological process involved in symbiotic interaction | 54/1272 | 290/18723 | 9.64e-12 | 1.73e-09 | 54 |
GO:005212630 | Thyroid | HT | movement in host environment | 36/1272 | 175/18723 | 1.73e-09 | 1.78e-07 | 36 |
GO:005170130 | Thyroid | HT | biological process involved in interaction with host | 37/1272 | 203/18723 | 3.17e-08 | 2.29e-06 | 37 |
GO:000250420 | Thyroid | HT | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 14/1272 | 36/18723 | 3.82e-08 | 2.65e-06 | 14 |
GO:004206030 | Thyroid | HT | wound healing | 60/1272 | 422/18723 | 4.06e-08 | 2.69e-06 | 60 |
GO:001988228 | Thyroid | HT | antigen processing and presentation | 23/1272 | 106/18723 | 5.40e-07 | 2.33e-05 | 23 |
GO:00024494 | Thyroid | HT | lymphocyte mediated immunity | 45/1272 | 350/18723 | 2.76e-05 | 6.05e-04 | 45 |
GO:00024434 | Thyroid | HT | leukocyte mediated immunity | 51/1272 | 440/18723 | 1.30e-04 | 2.07e-03 | 51 |
GO:001623620 | Thyroid | HT | macroautophagy | 36/1272 | 291/18723 | 3.60e-04 | 4.59e-03 | 36 |
GO:00070338 | Thyroid | HT | vacuole organization | 24/1272 | 180/18723 | 1.17e-03 | 1.15e-02 | 24 |
GO:000808818 | Thyroid | HT | axo-dendritic transport | 13/1272 | 75/18723 | 1.50e-03 | 1.39e-02 | 13 |
GO:00190768 | Thyroid | HT | viral release from host cell | 8/1272 | 34/18723 | 1.64e-03 | 1.50e-02 | 8 |
GO:00358908 | Thyroid | HT | exit from host | 8/1272 | 34/18723 | 1.64e-03 | 1.50e-02 | 8 |
GO:00358918 | Thyroid | HT | exit from host cell | 8/1272 | 34/18723 | 1.64e-03 | 1.50e-02 | 8 |
GO:00019068 | Thyroid | HT | cell killing | 24/1272 | 188/18723 | 2.12e-03 | 1.86e-02 | 24 |
GO:00069094 | Thyroid | HT | phagocytosis | 34/1272 | 308/18723 | 3.59e-03 | 2.73e-02 | 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513220 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa05132110 | Cervix | CC | Salmonella infection | 74/1267 | 249/8465 | 1.33e-09 | 2.54e-08 | 1.50e-08 | 74 |
hsa05132211 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa05132310 | Esophagus | ESCC | Salmonella infection | 191/4205 | 249/8465 | 6.51e-19 | 5.45e-17 | 2.79e-17 | 191 |
hsa0513242 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0513252 | Liver | HCC | Salmonella infection | 178/4020 | 249/8465 | 5.90e-15 | 1.98e-13 | 1.10e-13 | 178 |
hsa0513216 | Lung | IAC | Salmonella infection | 52/1053 | 249/8465 | 9.46e-05 | 1.28e-03 | 8.50e-04 | 52 |
hsa0513217 | Lung | IAC | Salmonella infection | 52/1053 | 249/8465 | 9.46e-05 | 1.28e-03 | 8.50e-04 | 52 |
hsa0513223 | Lung | AIS | Salmonella infection | 50/961 | 249/8465 | 3.47e-05 | 5.62e-04 | 3.59e-04 | 50 |
hsa0513233 | Lung | AIS | Salmonella infection | 50/961 | 249/8465 | 3.47e-05 | 5.62e-04 | 3.59e-04 | 50 |
hsa0513230 | Oral cavity | OSCC | Salmonella infection | 174/3704 | 249/8465 | 2.67e-17 | 1.49e-15 | 7.58e-16 | 174 |
hsa05132114 | Oral cavity | OSCC | Salmonella infection | 174/3704 | 249/8465 | 2.67e-17 | 1.49e-15 | 7.58e-16 | 174 |
hsa05132210 | Oral cavity | LP | Salmonella infection | 128/2418 | 249/8465 | 1.17e-14 | 2.79e-13 | 1.80e-13 | 128 |
hsa0513238 | Oral cavity | LP | Salmonella infection | 128/2418 | 249/8465 | 1.17e-14 | 2.79e-13 | 1.80e-13 | 128 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARL8B | SNV | Missense_Mutation | c.515N>G | p.Ile172Ser | p.I172S | Q9NVJ2 | protein_coding | tolerated(0.21) | benign(0.031) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ARL8B | SNV | Missense_Mutation | rs766948599 | c.323G>A | p.Arg108Gln | p.R108Q | Q9NVJ2 | protein_coding | tolerated(0.06) | benign(0.006) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
ARL8B | SNV | Missense_Mutation | c.344N>C | p.Leu115Pro | p.L115P | Q9NVJ2 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ARL8B | SNV | Missense_Mutation | rs780847749 | c.460N>A | p.Asp154Asn | p.D154N | Q9NVJ2 | protein_coding | tolerated(0.19) | benign(0.031) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
ARL8B | SNV | Missense_Mutation | c.150N>G | p.Ile50Met | p.I50M | Q9NVJ2 | protein_coding | deleterious(0) | probably_damaging(0.946) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ARL8B | SNV | Missense_Mutation | novel | c.308N>G | p.Lys103Arg | p.K103R | Q9NVJ2 | protein_coding | tolerated(0.09) | probably_damaging(0.966) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARL8B | SNV | Missense_Mutation | rs747994602 | c.193G>A | p.Val65Ile | p.V65I | Q9NVJ2 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-F4-6704-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
ARL8B | SNV | Missense_Mutation | novel | c.538N>T | p.His180Tyr | p.H180Y | Q9NVJ2 | protein_coding | tolerated(0.09) | possibly_damaging(0.855) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARL8B | SNV | Missense_Mutation | novel | c.398A>G | p.Asp133Gly | p.D133G | Q9NVJ2 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ARL8B | SNV | Missense_Mutation | rs747994602 | c.193G>A | p.Val65Ile | p.V65I | Q9NVJ2 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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