Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/AKAP9_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/AKAP9_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/AKAP9_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/AKAP9_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/AKAP9_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/AKAP9_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/AKAP9_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/AKAP9_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/AKAP9_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/AKAP9_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/AKAP9_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/AKAP9_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/AKAP9_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00860045 | Colorectum | CRC | regulation of cardiac muscle cell contraction | 13/2078 | 34/18723 | 3.64e-05 | 9.13e-04 | 13 |
GO:00182093 | Colorectum | CRC | peptidyl-serine modification | 62/2078 | 338/18723 | 4.67e-05 | 1.10e-03 | 62 |
GO:00347642 | Colorectum | CRC | positive regulation of transmembrane transport | 44/2078 | 219/18723 | 6.68e-05 | 1.45e-03 | 44 |
GO:00613372 | Colorectum | CRC | cardiac conduction | 24/2078 | 98/18723 | 1.39e-04 | 2.58e-03 | 24 |
GO:00860913 | Colorectum | CRC | regulation of heart rate by cardiac conduction | 13/2078 | 39/18723 | 1.87e-04 | 3.27e-03 | 13 |
GO:19031152 | Colorectum | CRC | regulation of actin filament-based movement | 13/2078 | 39/18723 | 1.87e-04 | 3.27e-03 | 13 |
GO:00109591 | Colorectum | CRC | regulation of metal ion transport | 69/2078 | 406/18723 | 2.05e-04 | 3.48e-03 | 69 |
GO:00324141 | Colorectum | CRC | positive regulation of ion transmembrane transporter activity | 25/2078 | 109/18723 | 3.06e-04 | 4.79e-03 | 25 |
GO:00030123 | Colorectum | CRC | muscle system process | 74/2078 | 452/18723 | 3.92e-04 | 5.80e-03 | 74 |
GO:0051642 | Colorectum | CRC | centrosome localization | 11/2078 | 32/18723 | 4.30e-04 | 6.34e-03 | 11 |
GO:00618421 | Colorectum | CRC | microtubule organizing center localization | 11/2078 | 33/18723 | 5.80e-04 | 7.89e-03 | 11 |
GO:00989001 | Colorectum | CRC | regulation of action potential | 15/2078 | 55/18723 | 7.21e-04 | 9.29e-03 | 15 |
GO:00705071 | Colorectum | CRC | regulation of microtubule cytoskeleton organization | 30/2078 | 148/18723 | 7.75e-04 | 9.87e-03 | 30 |
GO:00069372 | Colorectum | CRC | regulation of muscle contraction | 33/2078 | 169/18723 | 8.65e-04 | 1.07e-02 | 33 |
GO:0050804 | Colorectum | CRC | modulation of chemical synaptic transmission | 70/2078 | 439/18723 | 1.15e-03 | 1.33e-02 | 70 |
GO:0099177 | Colorectum | CRC | regulation of trans-synaptic signaling | 70/2078 | 440/18723 | 1.23e-03 | 1.38e-02 | 70 |
GO:00324114 | Colorectum | CRC | positive regulation of transporter activity | 25/2078 | 120/18723 | 1.37e-03 | 1.50e-02 | 25 |
GO:0035637 | Colorectum | CRC | multicellular organismal signaling | 31/2078 | 160/18723 | 1.39e-03 | 1.52e-02 | 31 |
GO:00432701 | Colorectum | CRC | positive regulation of ion transport | 47/2078 | 275/18723 | 1.74e-03 | 1.79e-02 | 47 |
GO:19040621 | Colorectum | CRC | regulation of cation transmembrane transport | 58/2078 | 357/18723 | 1.89e-03 | 1.93e-02 | 58 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AKAP9 | SNV | Missense_Mutation | | c.5677N>G | p.Leu1893Val | p.L1893V | Q99996 | protein_coding | tolerated(0.08) | benign(0.162) | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD |
AKAP9 | SNV | Missense_Mutation | | c.5825N>T | p.Thr1942Ile | p.T1942I | Q99996 | protein_coding | tolerated(0.3) | benign(0) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
AKAP9 | SNV | Missense_Mutation | | c.10727N>A | p.Ser3576Tyr | p.S3576Y | Q99996 | protein_coding | tolerated(0.56) | benign(0.007) | TCGA-A2-A0YM-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
AKAP9 | SNV | Missense_Mutation | novel | c.9220G>C | p.Glu3074Gln | p.E3074Q | Q99996 | protein_coding | tolerated(0.55) | benign(0.067) | TCGA-A7-A5ZW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
AKAP9 | SNV | Missense_Mutation | | c.938A>T | p.Asp313Val | p.D313V | Q99996 | protein_coding | tolerated(0.07) | benign(0.154) | TCGA-A8-A06T-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
AKAP9 | SNV | Missense_Mutation | | c.3185N>A | p.Gly1062Glu | p.G1062E | Q99996 | protein_coding | tolerated(0.85) | benign(0) | TCGA-A8-A092-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR |
AKAP9 | SNV | Missense_Mutation | | c.7369N>A | p.His2457Asn | p.H2457N | Q99996 | protein_coding | tolerated(0.31) | benign(0) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
AKAP9 | SNV | Missense_Mutation | | c.5839N>T | p.Arg1947Cys | p.R1947C | Q99996 | protein_coding | deleterious(0) | probably_damaging(0.951) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
AKAP9 | SNV | Missense_Mutation | rs745335257 | c.11617N>A | p.Asp3873Asn | p.D3873N | Q99996 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
AKAP9 | SNV | Missense_Mutation | novel | c.4243N>A | p.Glu1415Lys | p.E1415K | Q99996 | protein_coding | tolerated(0.17) | benign(0.061) | TCGA-AC-A3BB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | CR |