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Gene: AGA |
Gene summary for AGA |
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Gene information | Species | Human | Gene symbol | AGA | Gene ID | 175 |
Gene name | aspartylglucosaminidase | |
Gene Alias | AGU | |
Cytomap | 4q34.3 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | P20933 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
175 | AGA | LZE4T | Human | Esophagus | ESCC | 2.69e-08 | 2.18e-01 | 0.0811 |
175 | AGA | LZE5T | Human | Esophagus | ESCC | 3.81e-03 | 2.28e-01 | 0.0514 |
175 | AGA | LZE8T | Human | Esophagus | ESCC | 1.52e-06 | 2.33e-01 | 0.067 |
175 | AGA | LZE20T | Human | Esophagus | ESCC | 3.16e-02 | 2.08e-01 | 0.0662 |
175 | AGA | LZE22T | Human | Esophagus | ESCC | 2.53e-03 | 2.83e-01 | 0.068 |
175 | AGA | LZE24T | Human | Esophagus | ESCC | 6.79e-07 | 2.71e-01 | 0.0596 |
175 | AGA | P1T-E | Human | Esophagus | ESCC | 7.41e-04 | 3.62e-01 | 0.0875 |
175 | AGA | P2T-E | Human | Esophagus | ESCC | 8.41e-46 | 7.70e-01 | 0.1177 |
175 | AGA | P4T-E | Human | Esophagus | ESCC | 9.13e-05 | 2.27e-01 | 0.1323 |
175 | AGA | P5T-E | Human | Esophagus | ESCC | 1.02e-06 | 1.63e-01 | 0.1327 |
175 | AGA | P8T-E | Human | Esophagus | ESCC | 6.35e-16 | 2.63e-01 | 0.0889 |
175 | AGA | P9T-E | Human | Esophagus | ESCC | 1.59e-05 | 1.94e-01 | 0.1131 |
175 | AGA | P10T-E | Human | Esophagus | ESCC | 4.95e-04 | 5.76e-02 | 0.116 |
175 | AGA | P11T-E | Human | Esophagus | ESCC | 9.92e-09 | 5.44e-01 | 0.1426 |
175 | AGA | P12T-E | Human | Esophagus | ESCC | 2.44e-47 | 8.46e-01 | 0.1122 |
175 | AGA | P15T-E | Human | Esophagus | ESCC | 3.73e-07 | 1.67e-01 | 0.1149 |
175 | AGA | P16T-E | Human | Esophagus | ESCC | 4.90e-22 | 5.10e-01 | 0.1153 |
175 | AGA | P17T-E | Human | Esophagus | ESCC | 2.64e-05 | 2.77e-01 | 0.1278 |
175 | AGA | P20T-E | Human | Esophagus | ESCC | 2.88e-11 | 2.94e-01 | 0.1124 |
175 | AGA | P21T-E | Human | Esophagus | ESCC | 1.23e-28 | 5.46e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003166919 | Oral cavity | LP | cellular response to nutrient levels | 79/4623 | 215/18723 | 5.16e-05 | 7.21e-04 | 79 |
GO:000926718 | Oral cavity | LP | cellular response to starvation | 59/4623 | 156/18723 | 1.78e-04 | 1.99e-03 | 59 |
GO:005181713 | Oral cavity | LP | modulation of process of other organism involved in symbiotic interaction | 35/4623 | 81/18723 | 1.97e-04 | 2.16e-03 | 35 |
GO:004259417 | Oral cavity | LP | response to starvation | 71/4623 | 197/18723 | 2.36e-04 | 2.52e-03 | 71 |
GO:003582113 | Oral cavity | LP | modulation of process of other organism | 41/4623 | 106/18723 | 9.70e-04 | 8.20e-03 | 41 |
GO:000110115 | Oral cavity | LP | response to acid chemical | 47/4623 | 135/18723 | 5.29e-03 | 3.23e-02 | 47 |
GO:004320013 | Oral cavity | LP | response to amino acid | 41/4623 | 116/18723 | 6.57e-03 | 3.85e-02 | 41 |
GO:005105613 | Prostate | Tumor | regulation of small GTPase mediated signal transduction | 80/3246 | 302/18723 | 3.96e-05 | 4.57e-04 | 80 |
GO:001603229 | Skin | cSCC | viral process | 211/4864 | 415/18723 | 7.04e-28 | 2.76e-25 | 211 |
GO:004440328 | Skin | cSCC | biological process involved in symbiotic interaction | 126/4864 | 290/18723 | 6.39e-11 | 2.97e-09 | 126 |
GO:003133028 | Skin | cSCC | negative regulation of cellular catabolic process | 115/4864 | 262/18723 | 2.03e-10 | 8.72e-09 | 115 |
GO:000989527 | Skin | cSCC | negative regulation of catabolic process | 133/4864 | 320/18723 | 6.99e-10 | 2.77e-08 | 133 |
GO:005170129 | Skin | cSCC | biological process involved in interaction with host | 91/4864 | 203/18723 | 4.30e-09 | 1.45e-07 | 91 |
GO:001050619 | Skin | cSCC | regulation of autophagy | 127/4864 | 317/18723 | 2.36e-08 | 6.71e-07 | 127 |
GO:007149628 | Skin | cSCC | cellular response to external stimulus | 125/4864 | 320/18723 | 1.63e-07 | 3.65e-06 | 125 |
GO:003166825 | Skin | cSCC | cellular response to extracellular stimulus | 94/4864 | 246/18723 | 1.52e-05 | 1.87e-04 | 94 |
GO:000926722 | Skin | cSCC | cellular response to starvation | 64/4864 | 156/18723 | 2.79e-05 | 3.12e-04 | 64 |
GO:0042594110 | Skin | cSCC | response to starvation | 77/4864 | 197/18723 | 3.52e-05 | 3.82e-04 | 77 |
GO:005181715 | Skin | cSCC | modulation of process of other organism involved in symbiotic interaction | 38/4864 | 81/18723 | 3.88e-05 | 4.17e-04 | 38 |
GO:003166728 | Skin | cSCC | response to nutrient levels | 160/4864 | 474/18723 | 8.44e-05 | 8.02e-04 | 160 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa041424 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa0414211 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa041422 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa041423 | Liver | HCC | Lysosome | 100/4020 | 132/8465 | 2.32e-11 | 4.31e-10 | 2.40e-10 | 100 |
hsa041425 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
hsa0414212 | Oral cavity | OSCC | Lysosome | 87/3704 | 132/8465 | 1.97e-07 | 1.35e-06 | 6.86e-07 | 87 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
AGA | SNV | Missense_Mutation | rs763615962 | c.1000N>A | p.Glu334Lys | p.E334K | P20933 | protein_coding | tolerated(0.92) | benign(0.011) | TCGA-JX-A3Q0-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
AGA | SNV | Missense_Mutation | c.710N>G | p.Asp237Gly | p.D237G | P20933 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
AGA | SNV | Missense_Mutation | rs572348048 | c.700N>T | p.Arg234Cys | p.R234C | P20933 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
AGA | SNV | Missense_Mutation | novel | c.496N>T | p.Asn166Tyr | p.N166Y | P20933 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A02W-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
AGA | SNV | Missense_Mutation | c.516N>G | p.Ile172Met | p.I172M | P20933 | protein_coding | tolerated(0.18) | benign(0.027) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
AGA | SNV | Missense_Mutation | c.416N>C | p.Met139Thr | p.M139T | P20933 | protein_coding | deleterious(0.02) | probably_damaging(0.948) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
AGA | SNV | Missense_Mutation | novel | c.454N>A | p.Gln152Lys | p.Q152K | P20933 | protein_coding | tolerated(0.62) | benign(0) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
AGA | SNV | Missense_Mutation | rs572348048 | c.700C>T | p.Arg234Cys | p.R234C | P20933 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
AGA | SNV | Missense_Mutation | c.578N>A | p.Pro193His | p.P193H | P20933 | protein_coding | tolerated(0.21) | benign(0.009) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
AGA | SNV | Missense_Mutation | novel | c.128N>T | p.Ala43Val | p.A43V | P20933 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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