Tissue | Expression Dynamics | Abbreviation |
Breast | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Breast/NPM1_pca_on_diff_genes.png) | IDC: Invasive ductal carcinoma |
DCIS: Ductal carcinoma in situ |
Precancer(BRCA1-mut): Precancerous lesion from BRCA1 mutation carriers |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/NPM1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/NPM1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/NPM1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/NPM1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NPM1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/NPM1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NPM1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/NPM1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NPM1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/NPM1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NPM1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NPM1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003139651 | Stomach | SIM | regulation of protein ubiquitination | 25/708 | 210/18723 | 4.09e-07 | 2.72e-05 | 25 |
GO:00064135 | Stomach | SIM | translational initiation | 18/708 | 118/18723 | 4.58e-07 | 3.00e-05 | 18 |
GO:00422745 | Stomach | SIM | ribosomal small subunit biogenesis | 14/708 | 73/18723 | 5.03e-07 | 3.21e-05 | 14 |
GO:190332051 | Stomach | SIM | regulation of protein modification by small protein conjugation or removal | 27/708 | 242/18723 | 5.27e-07 | 3.32e-05 | 27 |
GO:005082151 | Stomach | SIM | protein stabilization | 23/708 | 191/18723 | 9.66e-07 | 5.56e-05 | 23 |
GO:003164751 | Stomach | SIM | regulation of protein stability | 30/708 | 298/18723 | 1.14e-06 | 6.23e-05 | 30 |
GO:00422545 | Stomach | SIM | ribosome biogenesis | 30/708 | 299/18723 | 1.22e-06 | 6.60e-05 | 30 |
GO:00422735 | Stomach | SIM | ribosomal large subunit biogenesis | 13/708 | 72/18723 | 2.62e-06 | 1.27e-04 | 13 |
GO:00457275 | Stomach | SIM | positive regulation of translation | 18/708 | 136/18723 | 3.78e-06 | 1.68e-04 | 18 |
GO:005134851 | Stomach | SIM | negative regulation of transferase activity | 27/708 | 268/18723 | 3.82e-06 | 1.68e-04 | 27 |
GO:00342505 | Stomach | SIM | positive regulation of cellular amide metabolic process | 19/708 | 162/18723 | 1.23e-05 | 4.32e-04 | 19 |
GO:007233151 | Stomach | SIM | signal transduction by p53 class mediator | 18/708 | 163/18723 | 4.66e-05 | 1.28e-03 | 18 |
GO:000838041 | Stomach | SIM | RNA splicing | 33/708 | 434/18723 | 1.20e-04 | 2.81e-03 | 33 |
GO:00075685 | Stomach | SIM | aging | 27/708 | 339/18723 | 2.33e-04 | 4.64e-03 | 27 |
GO:003311951 | Stomach | SIM | negative regulation of RNA splicing | 6/708 | 25/18723 | 2.74e-04 | 5.21e-03 | 6 |
GO:00106395 | Stomach | SIM | negative regulation of organelle organization | 27/708 | 348/18723 | 3.53e-04 | 6.34e-03 | 27 |
GO:00064695 | Stomach | SIM | negative regulation of protein kinase activity | 19/708 | 212/18723 | 4.58e-04 | 7.62e-03 | 19 |
GO:004348451 | Stomach | SIM | regulation of RNA splicing | 15/708 | 148/18723 | 4.97e-04 | 8.08e-03 | 15 |
GO:000037741 | Stomach | SIM | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 25/708 | 320/18723 | 5.21e-04 | 8.27e-03 | 25 |
GO:000039841 | Stomach | SIM | mRNA splicing, via spliceosome | 25/708 | 320/18723 | 5.21e-04 | 8.27e-03 | 25 |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4869 | NPM1 | CLINICALLY ACTIONABLE, DNA REPAIR, DRUGGABLE GENOME, DRUG RESISTANCE | | Crizotinib | CRIZOTINIB | 27009859,25749034,24509625,18089725,25421750 |
4869 | NPM1 | CLINICALLY ACTIONABLE, DNA REPAIR, DRUGGABLE GENOME, DRUG RESISTANCE | | IPP-204106 | | |
4869 | NPM1 | CLINICALLY ACTIONABLE, DNA REPAIR, DRUGGABLE GENOME, DRUG RESISTANCE | | N/A | | 19047294,26586702,16109776,26676635,26239249,25281355,24573385,25713434 |
4869 | NPM1 | CLINICALLY ACTIONABLE, DNA REPAIR, DRUGGABLE GENOME, DRUG RESISTANCE | | AZD3463 | | 27009859 |
4869 | NPM1 | CLINICALLY ACTIONABLE, DNA REPAIR, DRUGGABLE GENOME, DRUG RESISTANCE | | Deguelin | DEGUELIN | 25348016,25242579 |
4869 | NPM1 | CLINICALLY ACTIONABLE, DNA REPAIR, DRUGGABLE GENOME, DRUG RESISTANCE | | Venetoclax | VENETOCLAX | |
4869 | NPM1 | CLINICALLY ACTIONABLE, DNA REPAIR, DRUGGABLE GENOME, DRUG RESISTANCE | | EPZ004777 | | 27535106 |
4869 | NPM1 | CLINICALLY ACTIONABLE, DNA REPAIR, DRUGGABLE GENOME, DRUG RESISTANCE | | MI-503 | | 27535106 |
4869 | NPM1 | CLINICALLY ACTIONABLE, DNA REPAIR, DRUGGABLE GENOME, DRUG RESISTANCE | | TRETINOIN | TRETINOIN | 19965647,21719597 |
4869 | NPM1 | CLINICALLY ACTIONABLE, DNA REPAIR, DRUGGABLE GENOME, DRUG RESISTANCE | | Midostaurin | MIDOSTAURIN | |