Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/EBP_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/EBP_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/EBP_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/EBP_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/EBP_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/EBP_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/EBP_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006145826 | Thyroid | HT | reproductive system development | 46/1272 | 427/18723 | 1.31e-03 | 1.27e-02 | 46 |
GO:00456009 | Thyroid | HT | positive regulation of fat cell differentiation | 12/1272 | 66/18723 | 1.47e-03 | 1.37e-02 | 12 |
GO:00016595 | Thyroid | HT | temperature homeostasis | 23/1272 | 174/18723 | 1.64e-03 | 1.50e-02 | 23 |
GO:01061067 | Thyroid | HT | cold-induced thermogenesis | 20/1272 | 144/18723 | 1.77e-03 | 1.59e-02 | 20 |
GO:01201617 | Thyroid | HT | regulation of cold-induced thermogenesis | 20/1272 | 144/18723 | 1.77e-03 | 1.59e-02 | 20 |
GO:000716218 | Thyroid | HT | negative regulation of cell adhesion | 34/1272 | 303/18723 | 2.76e-03 | 2.27e-02 | 34 |
GO:19030384 | Thyroid | HT | negative regulation of leukocyte cell-cell adhesion | 19/1272 | 141/18723 | 3.22e-03 | 2.55e-02 | 19 |
GO:00020651 | Thyroid | HT | columnar/cuboidal epithelial cell differentiation | 14/1272 | 91/18723 | 3.23e-03 | 2.55e-02 | 14 |
GO:00456677 | Thyroid | HT | regulation of osteoblast differentiation | 18/1272 | 132/18723 | 3.58e-03 | 2.73e-02 | 18 |
GO:00508683 | Thyroid | HT | negative regulation of T cell activation | 17/1272 | 122/18723 | 3.65e-03 | 2.75e-02 | 17 |
GO:000170125 | Thyroid | HT | in utero embryonic development | 39/1272 | 367/18723 | 3.72e-03 | 2.78e-02 | 39 |
GO:000189025 | Thyroid | HT | placenta development | 19/1272 | 144/18723 | 4.08e-03 | 2.99e-02 | 19 |
GO:00512505 | Thyroid | HT | negative regulation of lymphocyte activation | 20/1272 | 157/18723 | 4.88e-03 | 3.34e-02 | 20 |
GO:003110016 | Thyroid | HT | animal organ regeneration | 12/1272 | 76/18723 | 4.98e-03 | 3.36e-02 | 12 |
GO:0032633 | Thyroid | HT | interleukin-4 production | 7/1272 | 33/18723 | 5.88e-03 | 3.74e-02 | 7 |
GO:0032673 | Thyroid | HT | regulation of interleukin-4 production | 7/1272 | 33/18723 | 5.88e-03 | 3.74e-02 | 7 |
GO:000257320 | Thyroid | HT | myeloid leukocyte differentiation | 24/1272 | 208/18723 | 7.69e-03 | 4.54e-02 | 24 |
GO:00084064 | Thyroid | HT | gonad development | 25/1272 | 221/18723 | 8.46e-03 | 4.82e-02 | 25 |
GO:00508665 | Thyroid | HT | negative regulation of cell activation | 24/1272 | 210/18723 | 8.63e-03 | 4.90e-02 | 24 |
GO:0034976113 | Thyroid | PTC | response to endoplasmic reticulum stress | 161/5968 | 256/18723 | 1.14e-24 | 3.27e-22 | 161 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
EBP | SNV | Missense_Mutation | rs782423797 | c.208N>T | p.Ala70Ser | p.A70S | Q15125 | protein_coding | tolerated(0.07) | possibly_damaging(0.489) | TCGA-AN-A0FL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-B6-A1KF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-C8-A273-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-D8-A1X7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | ChemotherapyHormone Therapy | doxorubicine+cyclophosphamide+tamoxifen | SD |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-E9-A1NG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD |
EBP | SNV | Missense_Mutation | rs782081345 | c.593N>G | p.Val198Gly | p.V198G | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-EW-A1J3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
EBP | deletion | Frame_Shift_Del | novel | c.170delC | p.Pro57HisfsTer22 | p.P57Hfs*22 | Q15125 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
EBP | SNV | Missense_Mutation | rs28935174 | c.440N>A | p.Arg147His | p.R147H | Q15125 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-A6-A56B-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | PD |