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Gene: ID1 |
Gene summary for ID1 |
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Gene information | Species | Human | Gene symbol | ID1 | Gene ID | 3397 |
Gene name | inhibitor of DNA binding 1, HLH protein | |
Gene Alias | ID | |
Cytomap | 20q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P41134 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3397 | ID1 | CA_HPV_1 | Human | Cervix | CC | 7.97e-12 | -3.48e-01 | 0.0264 |
3397 | ID1 | Tumor | Human | Cervix | CC | 1.21e-76 | 1.23e+00 | 0.1241 |
3397 | ID1 | sample1 | Human | Cervix | CC | 1.90e-04 | 5.41e-01 | 0.0959 |
3397 | ID1 | sample3 | Human | Cervix | CC | 5.41e-99 | 1.28e+00 | 0.1387 |
3397 | ID1 | H2 | Human | Cervix | HSIL_HPV | 8.78e-08 | 4.73e-01 | 0.0632 |
3397 | ID1 | L1 | Human | Cervix | CC | 1.70e-10 | 5.05e-01 | 0.0802 |
3397 | ID1 | T1 | Human | Cervix | CC | 3.61e-12 | 6.09e-01 | 0.0918 |
3397 | ID1 | T2 | Human | Cervix | CC | 7.60e-04 | 6.39e-01 | 0.0709 |
3397 | ID1 | T3 | Human | Cervix | CC | 6.95e-95 | 1.28e+00 | 0.1389 |
3397 | ID1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.07e-17 | 5.75e-01 | 0.0155 |
3397 | ID1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.19e-24 | 1.02e+00 | -0.1808 |
3397 | ID1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.83e-11 | 9.25e-01 | 0.0216 |
3397 | ID1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.23e-34 | 1.62e+00 | -0.0811 |
3397 | ID1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.31e-17 | 8.67e-01 | -0.1088 |
3397 | ID1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.33e-27 | 9.99e-01 | -0.1954 |
3397 | ID1 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.45e-08 | 1.35e+00 | -0.2602 |
3397 | ID1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.36e-06 | 1.12e+00 | -0.2196 |
3397 | ID1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.22e-33 | 1.41e+00 | -0.1207 |
3397 | ID1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.39e-14 | 9.42e-01 | -0.1526 |
3397 | ID1 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.52e-54 | 1.61e+00 | -0.1464 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005109841 | Stomach | WIM | regulation of binding | 20/426 | 363/18723 | 2.65e-04 | 5.71e-03 | 20 |
GO:003223341 | Stomach | WIM | positive regulation of actin filament bundle assembly | 7/426 | 63/18723 | 5.55e-04 | 9.43e-03 | 7 |
GO:003223141 | Stomach | WIM | regulation of actin filament bundle assembly | 9/426 | 105/18723 | 6.57e-04 | 1.07e-02 | 9 |
GO:005101741 | Stomach | WIM | actin filament bundle assembly | 11/426 | 157/18723 | 9.53e-04 | 1.46e-02 | 11 |
GO:190290541 | Stomach | WIM | positive regulation of supramolecular fiber organization | 13/426 | 209/18723 | 1.04e-03 | 1.55e-02 | 13 |
GO:000315841 | Stomach | WIM | endothelium development | 10/426 | 136/18723 | 1.11e-03 | 1.63e-02 | 10 |
GO:006157241 | Stomach | WIM | actin filament bundle organization | 11/426 | 161/18723 | 1.17e-03 | 1.68e-02 | 11 |
GO:00511014 | Stomach | WIM | regulation of DNA binding | 9/426 | 118/18723 | 1.51e-03 | 2.02e-02 | 9 |
GO:003295641 | Stomach | WIM | regulation of actin cytoskeleton organization | 17/426 | 358/18723 | 3.62e-03 | 3.60e-02 | 17 |
GO:011005341 | Stomach | WIM | regulation of actin filament organization | 14/426 | 278/18723 | 4.78e-03 | 4.33e-02 | 14 |
GO:004544631 | Stomach | WIM | endothelial cell differentiation | 8/426 | 118/18723 | 5.59e-03 | 4.78e-02 | 8 |
GO:005149541 | Stomach | WIM | positive regulation of cytoskeleton organization | 12/426 | 226/18723 | 5.78e-03 | 4.90e-02 | 12 |
GO:000609151 | Stomach | SIM | generation of precursor metabolites and energy | 58/708 | 490/18723 | 1.10e-14 | 5.18e-12 | 58 |
GO:00525475 | Stomach | SIM | regulation of peptidase activity | 54/708 | 461/18723 | 1.46e-13 | 6.25e-11 | 54 |
GO:00525485 | Stomach | SIM | regulation of endopeptidase activity | 51/708 | 432/18723 | 5.26e-13 | 2.07e-10 | 51 |
GO:00453335 | Stomach | SIM | cellular respiration | 34/708 | 230/18723 | 9.47e-12 | 3.19e-09 | 34 |
GO:00159805 | Stomach | SIM | energy derivation by oxidation of organic compounds | 40/708 | 318/18723 | 2.55e-11 | 7.53e-09 | 40 |
GO:200123351 | Stomach | SIM | regulation of apoptotic signaling pathway | 38/708 | 356/18723 | 8.83e-09 | 1.16e-06 | 38 |
GO:20012345 | Stomach | SIM | negative regulation of apoptotic signaling pathway | 28/708 | 224/18723 | 2.90e-08 | 3.11e-06 | 28 |
GO:00086375 | Stomach | SIM | apoptotic mitochondrial changes | 18/708 | 107/18723 | 1.00e-07 | 8.64e-06 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0401513 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa04015 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa040151 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa040152 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa04350 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa040153 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa043501 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa040154 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa040155 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa040156 | Colorectum | FAP | Rap1 signaling pathway | 53/1404 | 210/8465 | 7.93e-04 | 5.14e-03 | 3.13e-03 | 53 |
hsa043902 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa040157 | Colorectum | FAP | Rap1 signaling pathway | 53/1404 | 210/8465 | 7.93e-04 | 5.14e-03 | 3.13e-03 | 53 |
hsa043903 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa0401514 | Endometrium | AEH | Rap1 signaling pathway | 49/1197 | 210/8465 | 2.03e-04 | 1.78e-03 | 1.30e-03 | 49 |
hsa043909 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ID1 | KER | Skin | ADJ | ID2,ID3,JUNB, etc. | 1.65e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ID1 | SNV | Missense_Mutation | novel | c.283N>T | p.Leu95Phe | p.L95F | P41134 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ID1 | SNV | Missense_Mutation | novel | c.69N>C | p.Lys23Asn | p.K23N | P41134 | protein_coding | deleterious(0.01) | benign(0.444) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ID1 | SNV | Missense_Mutation | rs756315343 | c.350C>T | p.Thr117Ile | p.T117I | P41134 | protein_coding | tolerated(0.21) | benign(0.03) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ID1 | SNV | Missense_Mutation | c.391A>G | p.Thr131Ala | p.T131A | P41134 | protein_coding | tolerated(0.46) | benign(0.094) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ID1 | SNV | Missense_Mutation | c.313N>T | p.Leu105Phe | p.L105F | P41134 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A17H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ID1 | SNV | Missense_Mutation | novel | c.346N>A | p.Gly116Arg | p.G116R | P41134 | protein_coding | tolerated(0.42) | benign(0.007) | TCGA-SL-A6J9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ID1 | SNV | Missense_Mutation | novel | c.463N>A | p.Arg155Ser | p.R155S | P41134 | protein_coding | deleterious(0) | benign(0.44) | TCGA-DD-AADO-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ID1 | SNV | Missense_Mutation | c.64G>T | p.Gly22Cys | p.G22C | P41134 | protein_coding | tolerated(0.17) | probably_damaging(0.976) | TCGA-69-7978-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ID1 | SNV | Missense_Mutation | rs758048335 | c.103N>G | p.Leu35Val | p.L35V | P41134 | protein_coding | tolerated(0.09) | probably_damaging(0.991) | TCGA-34-8454-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ID1 | SNV | Missense_Mutation | c.338N>T | p.Ser113Phe | p.S113F | P41134 | protein_coding | deleterious(0) | benign(0.251) | TCGA-BR-7959-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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