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Gene: VPS37B |
Gene summary for VPS37B |
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Gene information | Species | Human | Gene symbol | VPS37B | Gene ID | 79720 |
Gene name | VPS37B subunit of ESCRT-I | |
Gene Alias | VPS37B | |
Cytomap | 12q24.31 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A024RBU0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79720 | VPS37B | CCI_1 | Human | Cervix | CC | 1.52e-02 | 7.09e-01 | 0.528 |
79720 | VPS37B | CCI_3 | Human | Cervix | CC | 2.56e-02 | 4.54e-01 | 0.516 |
79720 | VPS37B | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.90e-17 | -5.63e-01 | 0.0155 |
79720 | VPS37B | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.12e-07 | -5.28e-01 | -0.1808 |
79720 | VPS37B | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.27e-04 | -5.05e-01 | -0.0811 |
79720 | VPS37B | HTA11_78_2000001011 | Human | Colorectum | AD | 4.88e-04 | -4.01e-01 | -0.1088 |
79720 | VPS37B | HTA11_347_2000001011 | Human | Colorectum | AD | 5.00e-06 | -3.41e-01 | -0.1954 |
79720 | VPS37B | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.50e-05 | -5.08e-01 | -0.1207 |
79720 | VPS37B | HTA11_83_2000001011 | Human | Colorectum | SER | 8.90e-04 | -5.16e-01 | -0.1526 |
79720 | VPS37B | HTA11_696_2000001011 | Human | Colorectum | AD | 1.72e-13 | -4.96e-01 | -0.1464 |
79720 | VPS37B | HTA11_866_2000001011 | Human | Colorectum | AD | 5.32e-09 | -4.97e-01 | -0.1001 |
79720 | VPS37B | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.97e-08 | -4.70e-01 | -0.059 |
79720 | VPS37B | HTA11_546_2000001011 | Human | Colorectum | AD | 3.30e-04 | -5.54e-01 | -0.0842 |
79720 | VPS37B | HTA11_866_3004761011 | Human | Colorectum | AD | 5.61e-17 | -5.81e-01 | 0.096 |
79720 | VPS37B | HTA11_4255_2000001011 | Human | Colorectum | SER | 5.34e-03 | -6.07e-01 | 0.0446 |
79720 | VPS37B | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.34e-03 | -5.83e-01 | 0.0528 |
79720 | VPS37B | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.92e-08 | -5.54e-01 | 0.0338 |
79720 | VPS37B | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.28e-17 | -5.62e-01 | 0.0674 |
79720 | VPS37B | HTA11_6818_2000001011 | Human | Colorectum | AD | 4.43e-02 | -5.23e-01 | 0.0112 |
79720 | VPS37B | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.58e-07 | -5.79e-01 | 0.0588 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00190763 | Liver | Cirrhotic | viral release from host cell | 19/4634 | 34/18723 | 1.01e-04 | 1.05e-03 | 19 |
GO:00358903 | Liver | Cirrhotic | exit from host | 19/4634 | 34/18723 | 1.01e-04 | 1.05e-03 | 19 |
GO:00358913 | Liver | Cirrhotic | exit from host cell | 19/4634 | 34/18723 | 1.01e-04 | 1.05e-03 | 19 |
GO:19021882 | Liver | Cirrhotic | positive regulation of viral release from host cell | 9/4634 | 11/18723 | 1.15e-04 | 1.15e-03 | 9 |
GO:000662311 | Liver | Cirrhotic | protein targeting to vacuole | 20/4634 | 37/18723 | 1.25e-04 | 1.23e-03 | 20 |
GO:19039024 | Liver | Cirrhotic | positive regulation of viral life cycle | 16/4634 | 29/18723 | 4.36e-04 | 3.55e-03 | 16 |
GO:0043162 | Liver | Cirrhotic | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway | 12/4634 | 23/18723 | 4.23e-03 | 2.24e-02 | 12 |
GO:19021862 | Liver | Cirrhotic | regulation of viral release from host cell | 13/4634 | 26/18723 | 4.72e-03 | 2.48e-02 | 13 |
GO:007259422 | Liver | HCC | establishment of protein localization to organelle | 299/7958 | 422/18723 | 1.06e-32 | 6.10e-30 | 299 |
GO:001603222 | Liver | HCC | viral process | 286/7958 | 415/18723 | 4.41e-28 | 1.86e-25 | 286 |
GO:000660512 | Liver | HCC | protein targeting | 219/7958 | 314/18723 | 7.74e-23 | 1.49e-20 | 219 |
GO:001623621 | Liver | HCC | macroautophagy | 204/7958 | 291/18723 | 8.66e-22 | 1.41e-19 | 204 |
GO:001905822 | Liver | HCC | viral life cycle | 209/7958 | 317/18723 | 2.05e-17 | 2.09e-15 | 209 |
GO:001605021 | Liver | HCC | vesicle organization | 194/7958 | 300/18723 | 5.58e-15 | 3.97e-13 | 194 |
GO:009015012 | Liver | HCC | establishment of protein localization to membrane | 168/7958 | 260/18723 | 4.07e-13 | 2.13e-11 | 168 |
GO:004440322 | Liver | HCC | biological process involved in symbiotic interaction | 183/7958 | 290/18723 | 9.13e-13 | 4.59e-11 | 183 |
GO:000703421 | Liver | HCC | vacuolar transport | 108/7958 | 157/18723 | 2.22e-11 | 8.69e-10 | 108 |
GO:005079212 | Liver | HCC | regulation of viral process | 109/7958 | 164/18723 | 4.52e-10 | 1.45e-08 | 109 |
GO:004852411 | Liver | HCC | positive regulation of viral process | 52/7958 | 65/18723 | 6.70e-10 | 2.11e-08 | 52 |
GO:005170122 | Liver | HCC | biological process involved in interaction with host | 128/7958 | 203/18723 | 2.51e-09 | 6.91e-08 | 128 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041446 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041447 | Colorectum | FAP | Endocytosis | 78/1404 | 251/8465 | 6.20e-09 | 2.96e-07 | 1.80e-07 | 78 |
hsa041448 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa041449 | Colorectum | CRC | Endocytosis | 65/1091 | 251/8465 | 1.27e-08 | 1.06e-06 | 7.19e-07 | 65 |
hsa0414420 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa04144110 | Endometrium | AEH | Endocytosis | 56/1197 | 251/8465 | 2.58e-04 | 2.15e-03 | 1.57e-03 | 56 |
hsa0414424 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa0414434 | Endometrium | EEC | Endocytosis | 57/1237 | 251/8465 | 3.34e-04 | 2.82e-03 | 2.10e-03 | 57 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414412 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
hsa0414413 | Liver | Cirrhotic | Endocytosis | 119/2530 | 251/8465 | 2.33e-09 | 4.56e-08 | 2.81e-08 | 119 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
VPS37B | SNV | Missense_Mutation | c.214C>G | p.Arg72Gly | p.R72G | Q9H9H4 | protein_coding | tolerated(0.22) | benign(0.07) | TCGA-A2-A0YG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
VPS37B | insertion | In_Frame_Ins | novel | c.115_116insTGTATTGGACTAGTTTATGTATGG | p.Gln39delinsLeuTyrTrpThrSerLeuCysMetGlu | p.Q39delinsLYWTSLCME | Q9H9H4 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
VPS37B | SNV | Missense_Mutation | novel | c.517N>A | p.Leu173Met | p.L173M | Q9H9H4 | protein_coding | tolerated(0.3) | benign(0.054) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
VPS37B | SNV | Missense_Mutation | novel | c.349N>G | p.Ile117Val | p.I117V | Q9H9H4 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
VPS37B | SNV | Missense_Mutation | c.814N>T | p.Pro272Ser | p.P272S | Q9H9H4 | protein_coding | tolerated(0.14) | benign(0.031) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
VPS37B | SNV | Missense_Mutation | rs370211610 | c.722N>T | p.Pro241Leu | p.P241L | Q9H9H4 | protein_coding | deleterious(0) | benign(0.059) | TCGA-D5-6531-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
VPS37B | SNV | Missense_Mutation | c.480N>T | p.Gln160His | p.Q160H | Q9H9H4 | protein_coding | deleterious(0) | possibly_damaging(0.87) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
VPS37B | SNV | Missense_Mutation | rs761502771 | c.215N>A | p.Arg72His | p.R72H | Q9H9H4 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
VPS37B | insertion | Frame_Shift_Ins | rs747337112 | c.736_737insC | p.Arg246ProfsTer88 | p.R246Pfs*88 | Q9H9H4 | protein_coding | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
VPS37B | SNV | Missense_Mutation | novel | c.378G>T | p.Glu126Asp | p.E126D | Q9H9H4 | protein_coding | tolerated(0.39) | benign(0.279) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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