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Gene: TSKU |
Gene summary for TSKU |
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Gene information | Species | Human | Gene symbol | TSKU | Gene ID | 25987 |
Gene name | tsukushi, small leucine rich proteoglycan | |
Gene Alias | E2IG4 | |
Cytomap | 11q13.5 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R5J8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25987 | TSKU | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.68e-06 | 3.32e-01 | -0.1808 |
25987 | TSKU | HTA11_1938_2000001011 | Human | Colorectum | AD | 4.93e-04 | 2.47e-01 | -0.0811 |
25987 | TSKU | HTA11_347_2000001011 | Human | Colorectum | AD | 8.41e-05 | 1.47e-01 | -0.1954 |
25987 | TSKU | HTA11_696_2000001011 | Human | Colorectum | AD | 3.19e-02 | 1.54e-01 | -0.1464 |
25987 | TSKU | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.04e-09 | 3.26e-01 | -0.059 |
25987 | TSKU | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.11e-03 | 3.49e-01 | -0.1462 |
25987 | TSKU | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.09e-02 | 1.31e-01 | 0.294 |
25987 | TSKU | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.88e-07 | 2.72e-01 | 0.3859 |
25987 | TSKU | LZE2T | Human | Esophagus | ESCC | 7.61e-05 | 8.68e-01 | 0.082 |
25987 | TSKU | LZE4T | Human | Esophagus | ESCC | 1.55e-03 | 1.10e-01 | 0.0811 |
25987 | TSKU | LZE8T | Human | Esophagus | ESCC | 1.60e-02 | 4.60e-02 | 0.067 |
25987 | TSKU | LZE20T | Human | Esophagus | ESCC | 7.39e-04 | 6.50e-02 | 0.0662 |
25987 | TSKU | LZE24T | Human | Esophagus | ESCC | 1.49e-05 | 4.55e-02 | 0.0596 |
25987 | TSKU | P2T-E | Human | Esophagus | ESCC | 1.32e-80 | 1.29e+00 | 0.1177 |
25987 | TSKU | P4T-E | Human | Esophagus | ESCC | 8.04e-27 | 8.41e-01 | 0.1323 |
25987 | TSKU | P5T-E | Human | Esophagus | ESCC | 3.97e-15 | 3.50e-01 | 0.1327 |
25987 | TSKU | P8T-E | Human | Esophagus | ESCC | 3.78e-13 | 2.39e-01 | 0.0889 |
25987 | TSKU | P9T-E | Human | Esophagus | ESCC | 2.01e-23 | 7.31e-01 | 0.1131 |
25987 | TSKU | P10T-E | Human | Esophagus | ESCC | 1.19e-35 | 5.65e-01 | 0.116 |
25987 | TSKU | P11T-E | Human | Esophagus | ESCC | 3.68e-10 | 9.67e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032905 | Thyroid | ATC | transforming growth factor beta1 production | 9/6293 | 13/18723 | 9.35e-03 | 3.44e-02 | 9 |
GO:00034161 | Thyroid | ATC | endochondral bone growth | 15/6293 | 26/18723 | 9.95e-03 | 3.63e-02 | 15 |
GO:0021761 | Thyroid | ATC | limbic system development | 48/6293 | 107/18723 | 9.97e-03 | 3.63e-02 | 48 |
GO:0098868 | Thyroid | ATC | bone growth | 16/6293 | 29/18723 | 1.37e-02 | 4.77e-02 | 16 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TSKU | SNV | Missense_Mutation | novel | c.1002N>T | p.Lys334Asn | p.K334N | Q8WUA8 | protein_coding | tolerated(0.13) | benign(0.219) | TCGA-EW-A3U0-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
TSKU | SNV | Missense_Mutation | novel | c.686N>A | p.Gly229Glu | p.G229E | Q8WUA8 | protein_coding | tolerated(0.87) | benign(0.001) | TCGA-GM-A2DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
TSKU | SNV | Missense_Mutation | rs374470717 | c.376N>A | p.Glu126Lys | p.E126K | Q8WUA8 | protein_coding | tolerated(0.38) | benign(0.003) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
TSKU | SNV | Missense_Mutation | novel | c.1034C>G | p.Ser345Cys | p.S345C | Q8WUA8 | protein_coding | tolerated_low_confidence(0.06) | benign(0.237) | TCGA-ZJ-A8QR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TSKU | SNV | Missense_Mutation | novel | c.923T>C | p.Val308Ala | p.V308A | Q8WUA8 | protein_coding | deleterious(0) | benign(0.11) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TSKU | SNV | Missense_Mutation | c.205C>T | p.Arg69Trp | p.R69W | Q8WUA8 | protein_coding | deleterious(0.02) | possibly_damaging(0.729) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
TSKU | SNV | Missense_Mutation | novel | c.242C>T | p.Pro81Leu | p.P81L | Q8WUA8 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D5-6927-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TSKU | SNV | Missense_Mutation | rs567652702 | c.944G>A | p.Arg315Gln | p.R315Q | Q8WUA8 | protein_coding | tolerated(0.5) | benign(0.003) | TCGA-AJ-A2QO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TSKU | SNV | Missense_Mutation | novel | c.286C>T | p.Leu96Phe | p.L96F | Q8WUA8 | protein_coding | tolerated(0.19) | benign(0.039) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
TSKU | SNV | Missense_Mutation | rs753490849 | c.623N>A | p.Arg208His | p.R208H | Q8WUA8 | protein_coding | deleterious(0.03) | benign(0.139) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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