Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/TFRC_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/TFRC_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/TFRC_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/TFRC_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TFRC_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TFRC_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TFRC_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TFRC_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00068983 | Colorectum | CRC | receptor-mediated endocytosis | 50/2078 | 244/18723 | 1.27e-05 | 4.08e-04 | 50 |
GO:00182093 | Colorectum | CRC | peptidyl-serine modification | 62/2078 | 338/18723 | 4.67e-05 | 1.10e-03 | 62 |
GO:00444035 | Colorectum | CRC | biological process involved in symbiotic interaction | 55/2078 | 290/18723 | 4.82e-05 | 1.12e-03 | 55 |
GO:00431123 | Colorectum | CRC | receptor metabolic process | 36/2078 | 166/18723 | 5.86e-05 | 1.31e-03 | 36 |
GO:00106394 | Colorectum | CRC | negative regulation of organelle organization | 63/2078 | 348/18723 | 6.09e-05 | 1.35e-03 | 63 |
GO:00602495 | Colorectum | CRC | anatomical structure homeostasis | 57/2078 | 314/18723 | 1.24e-04 | 2.41e-03 | 57 |
GO:00300995 | Colorectum | CRC | myeloid cell differentiation | 66/2078 | 381/18723 | 1.59e-04 | 2.87e-03 | 66 |
GO:00517015 | Colorectum | CRC | biological process involved in interaction with host | 39/2078 | 203/18723 | 4.36e-04 | 6.40e-03 | 39 |
GO:00018945 | Colorectum | CRC | tissue homeostasis | 48/2078 | 268/18723 | 5.56e-04 | 7.70e-03 | 48 |
GO:00521265 | Colorectum | CRC | movement in host environment | 34/2078 | 175/18723 | 8.00e-04 | 1.01e-02 | 34 |
GO:00030181 | Colorectum | CRC | vascular process in circulatory system | 45/2078 | 263/18723 | 2.10e-03 | 2.08e-02 | 45 |
GO:00316233 | Colorectum | CRC | receptor internalization | 23/2078 | 113/18723 | 2.85e-03 | 2.58e-02 | 23 |
GO:0048771 | Colorectum | CRC | tissue remodeling | 32/2078 | 175/18723 | 3.08e-03 | 2.73e-02 | 32 |
GO:0045780 | Colorectum | CRC | positive regulation of bone resorption | 7/2078 | 19/18723 | 3.09e-03 | 2.73e-02 | 7 |
GO:19001805 | Colorectum | CRC | regulation of protein localization to nucleus | 26/2078 | 136/18723 | 3.91e-03 | 3.24e-02 | 26 |
GO:00467185 | Colorectum | CRC | viral entry into host cell | 27/2078 | 144/18723 | 4.38e-03 | 3.47e-02 | 27 |
GO:00025733 | Colorectum | CRC | myeloid leukocyte differentiation | 36/2078 | 208/18723 | 4.57e-03 | 3.57e-02 | 36 |
GO:00094103 | Colorectum | CRC | response to xenobiotic stimulus | 69/2078 | 462/18723 | 6.34e-03 | 4.61e-02 | 69 |
GO:00431223 | Colorectum | CRC | regulation of I-kappaB kinase/NF-kappaB signaling | 41/2078 | 249/18723 | 6.39e-03 | 4.64e-02 | 41 |
GO:01501042 | Colorectum | CRC | transport across blood-brain barrier | 18/2078 | 87/18723 | 6.50e-03 | 4.69e-02 | 18 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TFRC | SNV | Missense_Mutation | rs769366579 | c.1511C>T | p.Thr504Met | p.T504M | P02786 | protein_coding | deleterious(0.05) | benign(0.055) | TCGA-AN-A0FZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TFRC | SNV | Missense_Mutation | novel | c.145N>T | p.Asp49Tyr | p.D49Y | P02786 | protein_coding | deleterious(0.01) | possibly_damaging(0.819) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
TFRC | insertion | Frame_Shift_Ins | novel | c.1815_1816insTTCCCCTATAGGGACATTTTCCCCCAAAAGGA | p.Glu606PhefsTer13 | p.E606Ffs*13 | P02786 | protein_coding | | | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TFRC | SNV | Missense_Mutation | rs41298067 | c.2030G>A | p.Arg677His | p.R677H | P02786 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TFRC | SNV | Missense_Mutation | novel | c.323T>C | p.Val108Ala | p.V108A | P02786 | protein_coding | tolerated(0.85) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TFRC | SNV | Missense_Mutation | novel | c.2249N>T | p.Ser750Phe | p.S750F | P02786 | protein_coding | deleterious(0.02) | possibly_damaging(0.882) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TFRC | SNV | Missense_Mutation | rs764730449 | c.2155N>T | p.Arg719Cys | p.R719C | P02786 | protein_coding | tolerated(0.14) | probably_damaging(0.981) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TFRC | SNV | Missense_Mutation | novel | c.349N>G | p.Leu117Val | p.L117V | | protein_coding | deleterious_low_confidence(0.02) | unknown(0) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TFRC | SNV | Missense_Mutation | rs370784605 | c.395C>T | p.Ser132Leu | p.S132L | P02786 | protein_coding | deleterious(0.02) | probably_damaging(0.976) | TCGA-VS-A9UL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Unknown | Unknown | PD |
TFRC | SNV | Missense_Mutation | rs772641140 | c.362N>A | p.Arg121His | p.R121H | P02786 | protein_coding | tolerated(0.57) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |