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Gene: TAOK3 |
Gene summary for TAOK3 |
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Gene information | Species | Human | Gene symbol | TAOK3 | Gene ID | 51347 |
Gene name | TAO kinase 3 | |
Gene Alias | DPK | |
Cytomap | 12q24.23 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | Q9H2K8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51347 | TAOK3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.69e-05 | 5.53e-01 | -0.1808 |
51347 | TAOK3 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.03e-32 | 1.11e+00 | -0.1954 |
51347 | TAOK3 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.16e-09 | 1.19e+00 | -0.2602 |
51347 | TAOK3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.35e-03 | 7.20e-01 | -0.2196 |
51347 | TAOK3 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.52e-06 | 5.33e-01 | -0.1464 |
51347 | TAOK3 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.54e-06 | 4.54e-01 | -0.1001 |
51347 | TAOK3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.20e-04 | 4.87e-01 | -0.059 |
51347 | TAOK3 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.01e-18 | 1.39e+00 | 0.3487 |
51347 | TAOK3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.34e-42 | 2.43e+00 | 0.281 |
51347 | TAOK3 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.88e-08 | -4.69e-01 | 0.3005 |
51347 | TAOK3 | F007 | Human | Colorectum | FAP | 3.87e-03 | -3.98e-01 | 0.1176 |
51347 | TAOK3 | A002-C-010 | Human | Colorectum | FAP | 2.98e-03 | -3.05e-01 | 0.242 |
51347 | TAOK3 | A001-C-207 | Human | Colorectum | FAP | 2.09e-03 | -3.01e-01 | 0.1278 |
51347 | TAOK3 | A015-C-203 | Human | Colorectum | FAP | 9.65e-39 | -6.91e-01 | -0.1294 |
51347 | TAOK3 | A015-C-204 | Human | Colorectum | FAP | 1.03e-14 | -5.83e-01 | -0.0228 |
51347 | TAOK3 | A014-C-040 | Human | Colorectum | FAP | 3.82e-10 | -7.72e-01 | -0.1184 |
51347 | TAOK3 | A002-C-201 | Human | Colorectum | FAP | 1.21e-20 | -5.84e-01 | 0.0324 |
51347 | TAOK3 | A002-C-203 | Human | Colorectum | FAP | 1.69e-03 | -2.92e-01 | 0.2786 |
51347 | TAOK3 | A001-C-119 | Human | Colorectum | FAP | 2.23e-09 | -3.57e-01 | -0.1557 |
51347 | TAOK3 | A001-C-108 | Human | Colorectum | FAP | 6.65e-21 | -4.09e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043506 | Lung | IAC | regulation of JUN kinase activity | 14/2061 | 58/18723 | 3.47e-03 | 2.95e-02 | 14 |
GO:00435071 | Lung | IAC | positive regulation of JUN kinase activity | 11/2061 | 42/18723 | 4.72e-03 | 3.68e-02 | 11 |
GO:0043406 | Lung | IAC | positive regulation of MAP kinase activity | 22/2061 | 112/18723 | 4.92e-03 | 3.78e-02 | 22 |
GO:00328742 | Lung | IAC | positive regulation of stress-activated MAPK cascade | 24/2061 | 126/18723 | 5.13e-03 | 3.91e-02 | 24 |
GO:003109813 | Lung | AIS | stress-activated protein kinase signaling cascade | 51/1849 | 247/18723 | 2.69e-07 | 2.37e-05 | 51 |
GO:000725413 | Lung | AIS | JNK cascade | 38/1849 | 167/18723 | 7.27e-07 | 5.36e-05 | 38 |
GO:005140313 | Lung | AIS | stress-activated MAPK cascade | 48/1849 | 239/18723 | 1.38e-06 | 8.75e-05 | 48 |
GO:004340912 | Lung | AIS | negative regulation of MAPK cascade | 39/1849 | 180/18723 | 1.92e-06 | 1.12e-04 | 39 |
GO:004277011 | Lung | AIS | signal transduction in response to DNA damage | 37/1849 | 172/18723 | 4.17e-06 | 2.13e-04 | 37 |
GO:003367412 | Lung | AIS | positive regulation of kinase activity | 77/1849 | 467/18723 | 4.67e-06 | 2.31e-04 | 77 |
GO:007030213 | Lung | AIS | regulation of stress-activated protein kinase signaling cascade | 40/1849 | 195/18723 | 5.96e-06 | 2.78e-04 | 40 |
GO:004632812 | Lung | AIS | regulation of JNK cascade | 30/1849 | 133/18723 | 1.24e-05 | 4.75e-04 | 30 |
GO:004586012 | Lung | AIS | positive regulation of protein kinase activity | 65/1849 | 386/18723 | 1.27e-05 | 4.78e-04 | 65 |
GO:007190012 | Lung | AIS | regulation of protein serine/threonine kinase activity | 61/1849 | 359/18723 | 1.76e-05 | 6.17e-04 | 61 |
GO:004477211 | Lung | AIS | mitotic cell cycle phase transition | 69/1849 | 424/18723 | 2.23e-05 | 7.42e-04 | 69 |
GO:003287213 | Lung | AIS | regulation of stress-activated MAPK cascade | 38/1849 | 192/18723 | 2.36e-05 | 7.81e-04 | 38 |
GO:007190211 | Lung | AIS | positive regulation of protein serine/threonine kinase activity | 38/1849 | 200/18723 | 6.00e-05 | 1.65e-03 | 38 |
GO:00434101 | Lung | AIS | positive regulation of MAPK cascade | 72/1849 | 480/18723 | 2.11e-04 | 4.32e-03 | 72 |
GO:003287313 | Lung | AIS | negative regulation of stress-activated MAPK cascade | 14/1849 | 51/18723 | 3.07e-04 | 5.62e-03 | 14 |
GO:007030313 | Lung | AIS | negative regulation of stress-activated protein kinase signaling cascade | 14/1849 | 51/18723 | 3.07e-04 | 5.62e-03 | 14 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04010 | Colorectum | FAP | MAPK signaling pathway | 68/1404 | 302/8465 | 4.00e-03 | 1.67e-02 | 1.02e-02 | 68 |
hsa040101 | Colorectum | FAP | MAPK signaling pathway | 68/1404 | 302/8465 | 4.00e-03 | 1.67e-02 | 1.02e-02 | 68 |
hsa040102 | Colorectum | CRC | MAPK signaling pathway | 56/1091 | 302/8465 | 2.76e-03 | 1.77e-02 | 1.20e-02 | 56 |
hsa040103 | Colorectum | CRC | MAPK signaling pathway | 56/1091 | 302/8465 | 2.76e-03 | 1.77e-02 | 1.20e-02 | 56 |
hsa040108 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
hsa0401011 | Lung | IAC | MAPK signaling pathway | 62/1053 | 302/8465 | 3.54e-05 | 6.38e-04 | 4.24e-04 | 62 |
hsa0401021 | Lung | AIS | MAPK signaling pathway | 57/961 | 302/8465 | 6.41e-05 | 9.43e-04 | 6.03e-04 | 57 |
hsa0401031 | Lung | AIS | MAPK signaling pathway | 57/961 | 302/8465 | 6.41e-05 | 9.43e-04 | 6.03e-04 | 57 |
hsa040104 | Lung | AAH | MAPK signaling pathway | 27/348 | 302/8465 | 1.13e-04 | 6.32e-03 | 5.08e-03 | 27 |
hsa040105 | Lung | AAH | MAPK signaling pathway | 27/348 | 302/8465 | 1.13e-04 | 6.32e-03 | 5.08e-03 | 27 |
hsa0401014 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
hsa0401015 | Oral cavity | OSCC | MAPK signaling pathway | 165/3704 | 302/8465 | 7.11e-05 | 2.74e-04 | 1.40e-04 | 165 |
hsa0401023 | Oral cavity | EOLP | MAPK signaling pathway | 68/1218 | 302/8465 | 7.48e-05 | 3.40e-04 | 2.01e-04 | 68 |
hsa0401033 | Oral cavity | EOLP | MAPK signaling pathway | 68/1218 | 302/8465 | 7.48e-05 | 3.40e-04 | 2.01e-04 | 68 |
hsa0401041 | Oral cavity | NEOLP | MAPK signaling pathway | 59/1112 | 302/8465 | 9.40e-04 | 4.67e-03 | 2.94e-03 | 59 |
hsa0401051 | Oral cavity | NEOLP | MAPK signaling pathway | 59/1112 | 302/8465 | 9.40e-04 | 4.67e-03 | 2.94e-03 | 59 |
hsa0401010 | Prostate | BPH | MAPK signaling pathway | 87/1718 | 302/8465 | 2.05e-04 | 1.13e-03 | 6.98e-04 | 87 |
hsa0401013 | Prostate | BPH | MAPK signaling pathway | 87/1718 | 302/8465 | 2.05e-04 | 1.13e-03 | 6.98e-04 | 87 |
hsa0401022 | Prostate | Tumor | MAPK signaling pathway | 87/1791 | 302/8465 | 8.46e-04 | 3.94e-03 | 2.45e-03 | 87 |
hsa0401032 | Prostate | Tumor | MAPK signaling pathway | 87/1791 | 302/8465 | 8.46e-04 | 3.94e-03 | 2.45e-03 | 87 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TAOK3 | SNV | Missense_Mutation | novel | c.2532G>C | p.Gln844His | p.Q844H | Q9H2K8 | protein_coding | deleterious(0.02) | benign(0.03) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
TAOK3 | SNV | Missense_Mutation | novel | c.326C>T | p.Ser109Phe | p.S109F | Q9H2K8 | protein_coding | deleterious(0) | possibly_damaging(0.761) | TCGA-A8-A09B-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
TAOK3 | SNV | Missense_Mutation | novel | c.440N>G | p.Asp147Gly | p.D147G | Q9H2K8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0DI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
TAOK3 | SNV | Missense_Mutation | c.1485N>T | p.Lys495Asn | p.K495N | Q9H2K8 | protein_coding | deleterious(0) | probably_damaging(0.938) | TCGA-BH-A18S-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TAOK3 | SNV | Missense_Mutation | c.1603C>A | p.Gln535Lys | p.Q535K | Q9H2K8 | protein_coding | tolerated(0.72) | benign(0.109) | TCGA-D8-A1JL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TAOK3 | SNV | Missense_Mutation | c.2423N>C | p.Leu808Pro | p.L808P | Q9H2K8 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-E2-A15G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
TAOK3 | SNV | Missense_Mutation | c.2117N>A | p.Arg706Gln | p.R706Q | Q9H2K8 | protein_coding | deleterious(0) | possibly_damaging(0.573) | TCGA-E2-A1B5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TAOK3 | SNV | Missense_Mutation | novel | c.1310N>A | p.Thr437Lys | p.T437K | Q9H2K8 | protein_coding | deleterious(0) | probably_damaging(0.962) | TCGA-LP-A4AW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TAOK3 | SNV | Missense_Mutation | c.564G>T | p.Glu188Asp | p.E188D | Q9H2K8 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TAOK3 | SNV | Missense_Mutation | c.989N>G | p.Asp330Gly | p.D330G | Q9H2K8 | protein_coding | deleterious(0.03) | benign(0.027) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
51347 | TAOK3 | DNA REPAIR, SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 249565794 | ||
51347 | TAOK3 | DNA REPAIR, SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | morphine | MORPHINE | ||
51347 | TAOK3 | DNA REPAIR, SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | opioids | 30031856 | ||
51347 | TAOK3 | DNA REPAIR, SERINE THREONINE KINASE, KINASE, DRUGGABLE GENOME, ENZYME | inhibitor | 249565898 |
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