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Gene: SET |
Gene summary for SET |
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Gene information | Species | Human | Gene symbol | SET | Gene ID | 6418 |
Gene name | SET nuclear proto-oncogene | |
Gene Alias | 2PP2A | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q01105 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6418 | SET | GSM4909281 | Human | Breast | IDC | 1.19e-12 | 4.38e-01 | 0.21 |
6418 | SET | GSM4909282 | Human | Breast | IDC | 5.84e-06 | 2.65e-01 | -0.0288 |
6418 | SET | GSM4909286 | Human | Breast | IDC | 1.21e-04 | 2.05e-01 | 0.1081 |
6418 | SET | GSM4909288 | Human | Breast | IDC | 4.01e-02 | 8.44e-02 | 0.0988 |
6418 | SET | GSM4909290 | Human | Breast | IDC | 1.06e-06 | 3.80e-01 | 0.2096 |
6418 | SET | GSM4909293 | Human | Breast | IDC | 3.04e-10 | 3.72e-01 | 0.1581 |
6418 | SET | GSM4909294 | Human | Breast | IDC | 1.30e-17 | 2.92e-01 | 0.2022 |
6418 | SET | GSM4909296 | Human | Breast | IDC | 3.02e-15 | -3.98e-01 | 0.1524 |
6418 | SET | GSM4909297 | Human | Breast | IDC | 1.76e-25 | 2.22e-01 | 0.1517 |
6418 | SET | GSM4909306 | Human | Breast | IDC | 7.23e-03 | -2.71e-01 | 0.1564 |
6418 | SET | GSM4909309 | Human | Breast | IDC | 2.00e-02 | -2.24e-01 | 0.0483 |
6418 | SET | GSM4909311 | Human | Breast | IDC | 3.37e-49 | -5.41e-01 | 0.1534 |
6418 | SET | GSM4909312 | Human | Breast | IDC | 1.00e-09 | -2.43e-01 | 0.1552 |
6418 | SET | GSM4909317 | Human | Breast | IDC | 1.36e-02 | 2.79e-01 | 0.1355 |
6418 | SET | GSM4909318 | Human | Breast | IDC | 4.71e-08 | 4.81e-01 | 0.2031 |
6418 | SET | GSM4909319 | Human | Breast | IDC | 1.16e-58 | -8.01e-01 | 0.1563 |
6418 | SET | GSM4909320 | Human | Breast | IDC | 5.01e-11 | -7.26e-01 | 0.1575 |
6418 | SET | GSM4909321 | Human | Breast | IDC | 1.85e-12 | -3.31e-01 | 0.1559 |
6418 | SET | brca10 | Human | Breast | Precancer | 1.12e-11 | -5.22e-01 | -0.0029 |
6418 | SET | M2 | Human | Breast | IDC | 7.97e-12 | 4.74e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0043243 | Colorectum | AD | positive regulation of protein-containing complex disassembly | 14/3918 | 35/18723 | 7.92e-03 | 4.73e-02 | 14 |
GO:0006376 | Colorectum | AD | mRNA splice site selection | 18/3918 | 49/18723 | 7.93e-03 | 4.73e-02 | 18 |
GO:0043524 | Colorectum | AD | negative regulation of neuron apoptotic process | 43/3918 | 145/18723 | 8.04e-03 | 4.73e-02 | 43 |
GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
GO:00323861 | Colorectum | SER | regulation of intracellular transport | 89/2897 | 337/18723 | 1.34e-07 | 7.96e-06 | 89 |
GO:00069131 | Colorectum | SER | nucleocytoplasmic transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00511691 | Colorectum | SER | nuclear transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00329841 | Colorectum | SER | protein-containing complex disassembly | 61/2897 | 224/18723 | 4.17e-06 | 1.60e-04 | 61 |
GO:00343291 | Colorectum | SER | cell junction assembly | 100/2897 | 420/18723 | 4.23e-06 | 1.61e-04 | 100 |
GO:00018901 | Colorectum | SER | placenta development | 43/2897 | 144/18723 | 9.10e-06 | 3.03e-04 | 43 |
GO:00468221 | Colorectum | SER | regulation of nucleocytoplasmic transport | 34/2897 | 106/18723 | 1.46e-05 | 4.47e-04 | 34 |
GO:00018921 | Colorectum | SER | embryonic placenta development | 28/2897 | 82/18723 | 2.24e-05 | 6.43e-04 | 28 |
GO:00064031 | Colorectum | SER | RNA localization | 53/2897 | 201/18723 | 4.51e-05 | 1.13e-03 | 53 |
GO:00709971 | Colorectum | SER | neuron death | 84/2897 | 361/18723 | 5.76e-05 | 1.35e-03 | 84 |
GO:00510521 | Colorectum | SER | regulation of DNA metabolic process | 83/2897 | 359/18723 | 8.03e-05 | 1.77e-03 | 83 |
GO:00511681 | Colorectum | SER | nuclear export | 42/2897 | 154/18723 | 1.19e-04 | 2.46e-03 | 42 |
GO:00442701 | Colorectum | SER | cellular nitrogen compound catabolic process | 99/2897 | 451/18723 | 1.46e-04 | 2.86e-03 | 99 |
GO:00514021 | Colorectum | SER | neuron apoptotic process | 60/2897 | 246/18723 | 1.65e-04 | 3.13e-03 | 60 |
GO:00606691 | Colorectum | SER | embryonic placenta morphogenesis | 12/2897 | 26/18723 | 2.11e-04 | 3.78e-03 | 12 |
GO:00467001 | Colorectum | SER | heterocycle catabolic process | 97/2897 | 445/18723 | 2.20e-04 | 3.89e-03 | 97 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SET | SNV | Missense_Mutation | rs142648600 | c.548N>T | p.Ser183Leu | p.S183L | Q01105 | protein_coding | tolerated(0.16) | benign(0.11) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SET | SNV | Missense_Mutation | novel | c.270N>C | p.Lys90Asn | p.K90N | Q01105 | protein_coding | tolerated(0.05) | benign(0.16) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SET | SNV | Missense_Mutation | c.195N>C | p.Glu65Asp | p.E65D | Q01105 | protein_coding | deleterious(0.01) | possibly_damaging(0.651) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
SET | SNV | Missense_Mutation | novel | c.469N>A | p.His157Asn | p.H157N | Q01105 | protein_coding | tolerated(0.06) | benign(0.208) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
SET | SNV | Missense_Mutation | c.229C>T | p.Arg77Cys | p.R77C | Q01105 | protein_coding | tolerated(0.11) | benign(0.444) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SET | SNV | Missense_Mutation | c.572G>A | p.Ser191Asn | p.S191N | Q01105 | protein_coding | tolerated(0.16) | benign(0.029) | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SET | SNV | Missense_Mutation | c.260N>C | p.Leu87Ser | p.L87S | Q01105 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SET | SNV | Missense_Mutation | c.508N>A | p.Glu170Lys | p.E170K | Q01105 | protein_coding | tolerated(0.18) | benign(0.086) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SET | deletion | Frame_Shift_Del | c.273delN | p.Pro92GlnfsTer5 | p.P92Qfs*5 | Q01105 | protein_coding | TCGA-CM-5862-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
SET | SNV | Missense_Mutation | novel | c.161N>C | p.Glu54Ala | p.E54A | Q01105 | protein_coding | tolerated(0.06) | possibly_damaging(0.893) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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