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Gene: PINX1 |
Gene summary for PINX1 |
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Gene information | Species | Human | Gene symbol | PINX1 | Gene ID | 54984 |
Gene name | PIN2 (TERF1) interacting telomerase inhibitor 1 | |
Gene Alias | Gno1 | |
Cytomap | 8p23.1 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q96BK5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54984 | PINX1 | LZE4T | Human | Esophagus | ESCC | 5.64e-03 | 7.86e-02 | 0.0811 |
54984 | PINX1 | LZE24T | Human | Esophagus | ESCC | 7.17e-09 | 5.97e-02 | 0.0596 |
54984 | PINX1 | P2T-E | Human | Esophagus | ESCC | 3.59e-18 | 4.14e-01 | 0.1177 |
54984 | PINX1 | P4T-E | Human | Esophagus | ESCC | 8.22e-06 | 1.84e-02 | 0.1323 |
54984 | PINX1 | P5T-E | Human | Esophagus | ESCC | 6.43e-13 | 5.83e-02 | 0.1327 |
54984 | PINX1 | P8T-E | Human | Esophagus | ESCC | 1.60e-02 | -1.63e-02 | 0.0889 |
54984 | PINX1 | P9T-E | Human | Esophagus | ESCC | 8.31e-05 | 3.14e-02 | 0.1131 |
54984 | PINX1 | P10T-E | Human | Esophagus | ESCC | 1.08e-17 | 1.71e-01 | 0.116 |
54984 | PINX1 | P12T-E | Human | Esophagus | ESCC | 8.03e-13 | 1.09e-01 | 0.1122 |
54984 | PINX1 | P15T-E | Human | Esophagus | ESCC | 1.08e-05 | -2.30e-02 | 0.1149 |
54984 | PINX1 | P16T-E | Human | Esophagus | ESCC | 5.72e-17 | 1.52e-01 | 0.1153 |
54984 | PINX1 | P20T-E | Human | Esophagus | ESCC | 2.11e-08 | 2.59e-01 | 0.1124 |
54984 | PINX1 | P21T-E | Human | Esophagus | ESCC | 4.04e-17 | 1.77e-01 | 0.1617 |
54984 | PINX1 | P22T-E | Human | Esophagus | ESCC | 9.09e-10 | 1.14e-01 | 0.1236 |
54984 | PINX1 | P23T-E | Human | Esophagus | ESCC | 8.81e-14 | 2.00e-01 | 0.108 |
54984 | PINX1 | P24T-E | Human | Esophagus | ESCC | 2.81e-06 | 2.31e-01 | 0.1287 |
54984 | PINX1 | P26T-E | Human | Esophagus | ESCC | 1.17e-12 | 5.69e-02 | 0.1276 |
54984 | PINX1 | P27T-E | Human | Esophagus | ESCC | 2.15e-12 | 9.82e-02 | 0.1055 |
54984 | PINX1 | P28T-E | Human | Esophagus | ESCC | 2.49e-18 | 2.70e-01 | 0.1149 |
54984 | PINX1 | P30T-E | Human | Esophagus | ESCC | 7.90e-08 | 2.27e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19027492 | Skin | cSCC | regulation of cell cycle G2/M phase transition | 38/4864 | 102/18723 | 7.85e-03 | 3.65e-02 | 38 |
GO:2000279 | Skin | cSCC | negative regulation of DNA biosynthetic process | 17/4864 | 38/18723 | 9.41e-03 | 4.25e-02 | 17 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PINX1 | SNV | Missense_Mutation | novel | c.581N>G | p.Gln194Arg | p.Q194R | Q96BK5 | protein_coding | tolerated(0.06) | benign(0.092) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PINX1 | SNV | Missense_Mutation | c.857N>A | p.Gly286Asp | p.G286D | Q96BK5 | protein_coding | tolerated(1) | benign(0) | TCGA-BH-A1EY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PINX1 | insertion | Nonsense_Mutation | novel | c.561_562insTCACCTAATACTGATTTATCTGTCACATGGCTGTAAATAGTGAC | p.Ala188SerfsTer12 | p.A188Sfs*12 | Q96BK5 | protein_coding | TCGA-A2-A04Y-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
PINX1 | insertion | Nonsense_Mutation | novel | c.737_738insATCATTACAAATACATGCATTCATGTAAGTGTGCACAC | p.Glu247SerfsTer9 | p.E247Sfs*9 | Q96BK5 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
PINX1 | insertion | Frame_Shift_Ins | novel | c.441dupT | p.Gly148TrpfsTer6 | p.G148Wfs*6 | Q96BK5 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PINX1 | insertion | Frame_Shift_Ins | novel | c.541_542insGTGCGCATCTGTGTGTGTGTGTGTGTGTCACTATCTCC | p.Tyr181CysfsTer22 | p.Y181Cfs*22 | Q96BK5 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PINX1 | SNV | Missense_Mutation | c.538G>A | p.Glu180Lys | p.E180K | Q96BK5 | protein_coding | deleterious(0) | possibly_damaging(0.898) | TCGA-EK-A2R7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PINX1 | SNV | Missense_Mutation | c.853N>A | p.Glu285Lys | p.E285K | Q96BK5 | protein_coding | deleterious(0.05) | benign(0.006) | TCGA-FU-A2QG-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
PINX1 | SNV | Missense_Mutation | c.324G>T | p.Lys108Asn | p.K108N | Q96BK5 | protein_coding | deleterious(0.03) | possibly_damaging(0.635) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
PINX1 | SNV | Missense_Mutation | c.551N>C | p.Lys184Thr | p.K184T | Q96BK5 | protein_coding | deleterious(0.03) | benign(0.426) | TCGA-AA-3851-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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