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Gene: PID1 |
Gene summary for PID1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | PID1 | Gene ID | 55022 |
| Gene name | phosphotyrosine interaction domain containing 1 | |
| Gene Alias | HMFN2073 | |
| Cytomap | 2q36.3 | |
| Gene Type | protein-coding | GO ID | GO:0001932 | UniProtAcc | Q7Z2X4 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55022 | PID1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.27e-18 | -6.95e-01 | 0.0155 |
| 55022 | PID1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.75e-03 | -4.58e-01 | -0.1808 |
| 55022 | PID1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.87e-12 | 7.05e-01 | -0.1954 |
| 55022 | PID1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.85e-08 | -7.99e-01 | -0.1207 |
| 55022 | PID1 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.41e-05 | -5.51e-01 | 0.096 |
| 55022 | PID1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 4.85e-02 | -7.30e-01 | 0.0446 |
| 55022 | PID1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 5.52e-04 | -7.72e-01 | 0.0528 |
| 55022 | PID1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.13e-07 | -7.06e-01 | 0.0338 |
| 55022 | PID1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.55e-20 | -6.83e-01 | 0.0674 |
| 55022 | PID1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 1.93e-03 | -3.82e-01 | -0.0124 |
| 55022 | PID1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.44e-44 | -9.88e-01 | 0.294 |
| 55022 | PID1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.41e-43 | -1.01e+00 | 0.3859 |
| 55022 | PID1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 8.46e-07 | -7.97e-01 | 0.2585 |
| 55022 | PID1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 9.35e-39 | -9.09e-01 | 0.3005 |
| 55022 | PID1 | A001-C-207 | Human | Colorectum | FAP | 3.23e-03 | -4.05e-01 | 0.1278 |
| 55022 | PID1 | A015-C-203 | Human | Colorectum | FAP | 1.39e-27 | -6.74e-01 | -0.1294 |
| 55022 | PID1 | A015-C-204 | Human | Colorectum | FAP | 7.98e-06 | -4.06e-01 | -0.0228 |
| 55022 | PID1 | A014-C-040 | Human | Colorectum | FAP | 8.80e-05 | -5.88e-01 | -0.1184 |
| 55022 | PID1 | A002-C-201 | Human | Colorectum | FAP | 2.51e-12 | -5.07e-01 | 0.0324 |
| 55022 | PID1 | A001-C-119 | Human | Colorectum | FAP | 9.03e-17 | -8.31e-01 | -0.1557 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0008286 | Colorectum | FAP | insulin receptor signaling pathway | 28/2622 | 116/18723 | 2.37e-03 | 1.89e-02 | 28 |
| GO:00091423 | Colorectum | FAP | nucleoside triphosphate biosynthetic process | 22/2622 | 85/18723 | 2.66e-03 | 2.07e-02 | 22 |
| GO:19054761 | Colorectum | FAP | negative regulation of protein localization to membrane | 11/2622 | 32/18723 | 3.01e-03 | 2.27e-02 | 11 |
| GO:0006140 | Colorectum | FAP | regulation of nucleotide metabolic process | 22/2622 | 86/18723 | 3.11e-03 | 2.33e-02 | 22 |
| GO:0030810 | Colorectum | FAP | positive regulation of nucleotide biosynthetic process | 9/2622 | 24/18723 | 3.66e-03 | 2.60e-02 | 9 |
| GO:1900373 | Colorectum | FAP | positive regulation of purine nucleotide biosynthetic process | 9/2622 | 24/18723 | 3.66e-03 | 2.60e-02 | 9 |
| GO:0046324 | Colorectum | FAP | regulation of glucose import | 16/2622 | 59/18723 | 5.95e-03 | 3.75e-02 | 16 |
| GO:0010827 | Colorectum | FAP | regulation of glucose transmembrane transport | 19/2622 | 77/18723 | 8.67e-03 | 4.98e-02 | 19 |
| GO:00726595 | Colorectum | CRC | protein localization to plasma membrane | 80/2078 | 284/18723 | 1.36e-15 | 4.07e-12 | 80 |
| GO:19907785 | Colorectum | CRC | protein localization to cell periphery | 85/2078 | 333/18723 | 8.75e-14 | 1.05e-10 | 85 |
| GO:19043754 | Colorectum | CRC | regulation of protein localization to cell periphery | 36/2078 | 125/18723 | 4.62e-08 | 5.91e-06 | 36 |
| GO:19054754 | Colorectum | CRC | regulation of protein localization to membrane | 45/2078 | 175/18723 | 4.64e-08 | 5.91e-06 | 45 |
| GO:19030764 | Colorectum | CRC | regulation of protein localization to plasma membrane | 31/2078 | 104/18723 | 1.66e-07 | 1.72e-05 | 31 |
| GO:00091505 | Colorectum | CRC | purine ribonucleotide metabolic process | 74/2078 | 368/18723 | 2.58e-07 | 2.38e-05 | 74 |
| GO:00061635 | Colorectum | CRC | purine nucleotide metabolic process | 78/2078 | 396/18723 | 2.98e-07 | 2.59e-05 | 78 |
| GO:00092594 | Colorectum | CRC | ribonucleotide metabolic process | 75/2078 | 385/18723 | 7.83e-07 | 5.04e-05 | 75 |
| GO:00725215 | Colorectum | CRC | purine-containing compound metabolic process | 79/2078 | 416/18723 | 1.15e-06 | 6.75e-05 | 79 |
| GO:00196934 | Colorectum | CRC | ribose phosphate metabolic process | 75/2078 | 396/18723 | 2.36e-06 | 1.13e-04 | 75 |
| GO:19035803 | Colorectum | CRC | positive regulation of ATP metabolic process | 15/2078 | 38/18723 | 5.82e-06 | 2.28e-04 | 15 |
| GO:00434344 | Colorectum | CRC | response to peptide hormone | 76/2078 | 414/18723 | 6.67e-06 | 2.56e-04 | 76 |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| PID1 | SNV | Missense_Mutation | rs374635933 | c.640N>A | p.Ala214Thr | p.A214T | Q7Z2X4 | protein_coding | tolerated(0.22) | benign(0.141) | TCGA-BH-A0HW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
| PID1 | SNV | Missense_Mutation | novel | c.64C>A | p.Leu22Ile | p.L22I | Q7Z2X4 | protein_coding | tolerated_low_confidence(0.1) | benign(0) | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
| PID1 | SNV | Missense_Mutation | novel | c.95G>A | p.Arg32His | p.R32H | Q7Z2X4 | protein_coding | deleterious_low_confidence(0.01) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| PID1 | SNV | Missense_Mutation | c.209N>C | p.Glu70Ala | p.E70A | Q7Z2X4 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.98) | TCGA-EA-A3HQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| PID1 | SNV | Missense_Mutation | novel | c.619G>A | p.Glu207Lys | p.E207K | Q7Z2X4 | protein_coding | tolerated(0.63) | probably_damaging(0.951) | TCGA-EA-A97N-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| PID1 | SNV | Missense_Mutation | c.471N>A | p.His157Gln | p.H157Q | Q7Z2X4 | protein_coding | deleterious(0.01) | benign(0.313) | TCGA-EK-A2PL-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
| PID1 | SNV | Missense_Mutation | rs267599242 | c.118G>A | p.Glu40Lys | p.E40K | Q7Z2X4 | protein_coding | deleterious_low_confidence(0.02) | benign(0) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| PID1 | SNV | Missense_Mutation | novel | c.22N>T | p.Arg8Cys | p.R8C | Q7Z2X4 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.835) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| PID1 | SNV | Missense_Mutation | c.511N>A | p.Ala171Thr | p.A171T | Q7Z2X4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| PID1 | SNV | Missense_Mutation | rs756817470 | c.415N>T | p.Arg139Trp | p.R139W | Q7Z2X4 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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