![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PHF1 |
Gene summary for PHF1 |
![]() |
Gene information | Species | Human | Gene symbol | PHF1 | Gene ID | 5252 |
Gene name | PHD finger protein 1 | |
Gene Alias | MTF2L2 | |
Cytomap | 6p21.32 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | A0A140VJR4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5252 | PHF1 | LZE4T | Human | Esophagus | ESCC | 7.65e-07 | 8.03e-02 | 0.0811 |
5252 | PHF1 | LZE5T | Human | Esophagus | ESCC | 5.01e-03 | 1.84e-01 | 0.0514 |
5252 | PHF1 | LZE8T | Human | Esophagus | ESCC | 3.01e-03 | -7.49e-03 | 0.067 |
5252 | PHF1 | LZE20T | Human | Esophagus | ESCC | 2.18e-13 | 3.21e-01 | 0.0662 |
5252 | PHF1 | LZE22T | Human | Esophagus | ESCC | 6.43e-06 | 3.87e-01 | 0.068 |
5252 | PHF1 | LZE24T | Human | Esophagus | ESCC | 2.92e-16 | 4.77e-01 | 0.0596 |
5252 | PHF1 | LZE21T | Human | Esophagus | ESCC | 7.54e-06 | 3.77e-01 | 0.0655 |
5252 | PHF1 | LZE6T | Human | Esophagus | ESCC | 3.97e-05 | 3.62e-02 | 0.0845 |
5252 | PHF1 | P1T-E | Human | Esophagus | ESCC | 8.89e-04 | 4.33e-01 | 0.0875 |
5252 | PHF1 | P2T-E | Human | Esophagus | ESCC | 9.01e-32 | 5.60e-01 | 0.1177 |
5252 | PHF1 | P4T-E | Human | Esophagus | ESCC | 1.75e-13 | 2.00e-01 | 0.1323 |
5252 | PHF1 | P5T-E | Human | Esophagus | ESCC | 3.61e-09 | 1.37e-02 | 0.1327 |
5252 | PHF1 | P8T-E | Human | Esophagus | ESCC | 4.91e-22 | 1.77e-01 | 0.0889 |
5252 | PHF1 | P9T-E | Human | Esophagus | ESCC | 5.14e-05 | 1.32e-01 | 0.1131 |
5252 | PHF1 | P10T-E | Human | Esophagus | ESCC | 9.41e-16 | 2.13e-01 | 0.116 |
5252 | PHF1 | P11T-E | Human | Esophagus | ESCC | 2.00e-22 | 6.26e-01 | 0.1426 |
5252 | PHF1 | P12T-E | Human | Esophagus | ESCC | 5.68e-30 | 3.01e-01 | 0.1122 |
5252 | PHF1 | P15T-E | Human | Esophagus | ESCC | 1.48e-20 | 2.58e-01 | 0.1149 |
5252 | PHF1 | P16T-E | Human | Esophagus | ESCC | 1.49e-21 | 3.22e-01 | 0.1153 |
5252 | PHF1 | P17T-E | Human | Esophagus | ESCC | 2.23e-07 | 4.82e-01 | 0.1278 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004886321 | Thyroid | ATC | stem cell differentiation | 97/6293 | 206/18723 | 3.88e-05 | 3.15e-04 | 97 |
GO:003106212 | Thyroid | ATC | positive regulation of histone methylation | 26/6293 | 41/18723 | 8.96e-05 | 6.59e-04 | 26 |
GO:001657115 | Thyroid | ATC | histone methylation | 69/6293 | 141/18723 | 1.14e-04 | 8.16e-04 | 69 |
GO:000647916 | Thyroid | ATC | protein methylation | 85/6293 | 181/18723 | 1.27e-04 | 9.00e-04 | 85 |
GO:000821316 | Thyroid | ATC | protein alkylation | 85/6293 | 181/18723 | 1.27e-04 | 9.00e-04 | 85 |
GO:003106015 | Thyroid | ATC | regulation of histone methylation | 38/6293 | 69/18723 | 1.97e-04 | 1.31e-03 | 38 |
GO:004396611 | Thyroid | ATC | histone H3 acetylation | 34/6293 | 61/18723 | 3.10e-04 | 1.94e-03 | 34 |
GO:003496815 | Thyroid | ATC | histone lysine methylation | 54/6293 | 115/18723 | 2.00e-03 | 9.58e-03 | 54 |
GO:004341412 | Thyroid | ATC | macromolecule methylation | 131/6293 | 316/18723 | 2.01e-03 | 9.60e-03 | 131 |
GO:003225911 | Thyroid | ATC | methylation | 148/6293 | 364/18723 | 2.69e-03 | 1.23e-02 | 148 |
GO:003105712 | Thyroid | ATC | negative regulation of histone modification | 24/6293 | 46/18723 | 7.13e-03 | 2.82e-02 | 24 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHF1 | SNV | Missense_Mutation | novel | c.938A>G | p.Lys313Arg | p.K313R | O43189 | protein_coding | deleterious(0.03) | possibly_damaging(0.757) | TCGA-A7-A4SE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
PHF1 | SNV | Missense_Mutation | rs767831440 | c.748C>T | p.Arg250Cys | p.R250C | O43189 | protein_coding | deleterious(0) | possibly_damaging(0.725) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PHF1 | SNV | Missense_Mutation | rs759664324 | c.314T>G | p.Val105Gly | p.V105G | O43189 | protein_coding | deleterious(0) | benign(0.386) | TCGA-AN-A0AT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PHF1 | SNV | Missense_Mutation | novel | c.188N>G | p.Val63Gly | p.V63G | O43189 | protein_coding | deleterious(0) | possibly_damaging(0.829) | TCGA-AO-A1KT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD |
PHF1 | SNV | Missense_Mutation | rs368297880 | c.41N>T | p.Ser14Leu | p.S14L | O43189 | protein_coding | tolerated_low_confidence(0.13) | benign(0) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
PHF1 | insertion | Frame_Shift_Ins | novel | c.844_845insTTATCACCAGGACTGCCATGTTCCCAGGG | p.Ser282PhefsTer105 | p.S282Ffs*105 | O43189 | protein_coding | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
PHF1 | deletion | Frame_Shift_Del | novel | c.237delN | p.Pro80LeufsTer72 | p.P80Lfs*72 | O43189 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
PHF1 | insertion | Frame_Shift_Ins | novel | c.456_457insA | p.Tyr156LeufsTer58 | p.Y156Lfs*58 | O43189 | protein_coding | TCGA-OL-A66P-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR | ||
PHF1 | SNV | Missense_Mutation | rs779056192 | c.445G>T | p.Gly149Cys | p.G149C | O43189 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PHF1 | SNV | Missense_Mutation | novel | c.691N>C | p.Glu231Gln | p.E231Q | O43189 | protein_coding | tolerated(0.13) | benign(0.021) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |