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Gene: PFKL |
Gene summary for PFKL |
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Gene information | Species | Human | Gene symbol | PFKL | Gene ID | 5211 |
Gene name | phosphofructokinase, liver type | |
Gene Alias | ATP-PFK | |
Cytomap | 21q22.3 | |
Gene Type | protein-coding | GO ID | GO:0002790 | UniProtAcc | P17858 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5211 | PFKL | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.90e-14 | 7.35e-01 | -0.1808 |
5211 | PFKL | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.48e-22 | 9.08e-01 | -0.0811 |
5211 | PFKL | HTA11_78_2000001011 | Human | Colorectum | AD | 1.73e-06 | 5.01e-01 | -0.1088 |
5211 | PFKL | HTA11_347_2000001011 | Human | Colorectum | AD | 3.28e-14 | 5.31e-01 | -0.1954 |
5211 | PFKL | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.06e-04 | 8.20e-01 | -0.2196 |
5211 | PFKL | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.69e-08 | 6.38e-01 | -0.1207 |
5211 | PFKL | HTA11_83_2000001011 | Human | Colorectum | SER | 9.50e-06 | 5.53e-01 | -0.1526 |
5211 | PFKL | HTA11_696_2000001011 | Human | Colorectum | AD | 9.32e-12 | 5.02e-01 | -0.1464 |
5211 | PFKL | HTA11_866_2000001011 | Human | Colorectum | AD | 1.12e-08 | 3.63e-01 | -0.1001 |
5211 | PFKL | HTA11_1391_2000001011 | Human | Colorectum | AD | 6.17e-20 | 7.94e-01 | -0.059 |
5211 | PFKL | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.65e-02 | 6.36e-01 | -0.1706 |
5211 | PFKL | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.08e-04 | 7.44e-01 | -0.1462 |
5211 | PFKL | HTA11_866_3004761011 | Human | Colorectum | AD | 3.02e-04 | 3.84e-01 | 0.096 |
5211 | PFKL | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.45e-02 | 4.68e-01 | 0.0446 |
5211 | PFKL | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.54e-03 | 6.22e-01 | 0.0528 |
5211 | PFKL | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.25e-02 | 4.03e-01 | 0.0338 |
5211 | PFKL | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.57e-07 | 3.81e-01 | 0.294 |
5211 | PFKL | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.02e-07 | 5.04e-01 | 0.3859 |
5211 | PFKL | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.00e-11 | 4.89e-01 | 0.3005 |
5211 | PFKL | A015-C-203 | Human | Colorectum | FAP | 1.16e-04 | 2.25e-01 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00617182 | Colorectum | CRC | glucose catabolic process to pyruvate | 5/2078 | 10/18723 | 2.61e-03 | 2.40e-02 | 5 |
GO:00060071 | Colorectum | CRC | glucose catabolic process | 7/2078 | 19/18723 | 3.09e-03 | 2.73e-02 | 7 |
GO:00097495 | Colorectum | CRC | response to glucose | 37/2078 | 212/18723 | 3.54e-03 | 3.00e-02 | 37 |
GO:00510513 | Colorectum | CRC | negative regulation of transport | 71/2078 | 470/18723 | 4.33e-03 | 3.47e-02 | 71 |
GO:00507964 | Colorectum | CRC | regulation of insulin secretion | 30/2078 | 165/18723 | 4.44e-03 | 3.48e-02 | 30 |
GO:00300734 | Colorectum | CRC | insulin secretion | 34/2078 | 195/18723 | 5.10e-03 | 3.91e-02 | 34 |
GO:00158334 | Colorectum | CRC | peptide transport | 43/2078 | 264/18723 | 6.47e-03 | 4.68e-02 | 43 |
GO:00616201 | Colorectum | CRC | glycolytic process through glucose-6-phosphate | 5/2078 | 12/18723 | 6.79e-03 | 4.77e-02 | 5 |
GO:0006091110 | Esophagus | ESCC | generation of precursor metabolites and energy | 331/8552 | 490/18723 | 3.86e-23 | 8.45e-21 | 331 |
GO:0046034111 | Esophagus | ESCC | ATP metabolic process | 189/8552 | 277/18723 | 1.99e-14 | 1.04e-12 | 189 |
GO:0006753110 | Esophagus | ESCC | nucleoside phosphate metabolic process | 288/8552 | 497/18723 | 1.80e-08 | 3.50e-07 | 288 |
GO:0019693111 | Esophagus | ESCC | ribose phosphate metabolic process | 234/8552 | 396/18723 | 4.24e-08 | 7.76e-07 | 234 |
GO:0009117111 | Esophagus | ESCC | nucleotide metabolic process | 282/8552 | 489/18723 | 4.70e-08 | 8.50e-07 | 282 |
GO:00059969 | Esophagus | ESCC | monosaccharide metabolic process | 159/8552 | 257/18723 | 1.11e-07 | 1.81e-06 | 159 |
GO:00193189 | Esophagus | ESCC | hexose metabolic process | 147/8552 | 237/18723 | 2.63e-07 | 3.94e-06 | 147 |
GO:0009259111 | Esophagus | ESCC | ribonucleotide metabolic process | 224/8552 | 385/18723 | 4.41e-07 | 6.00e-06 | 224 |
GO:0072521111 | Esophagus | ESCC | purine-containing compound metabolic process | 238/8552 | 416/18723 | 1.20e-06 | 1.49e-05 | 238 |
GO:0009150111 | Esophagus | ESCC | purine ribonucleotide metabolic process | 213/8552 | 368/18723 | 1.40e-06 | 1.69e-05 | 213 |
GO:0006163111 | Esophagus | ESCC | purine nucleotide metabolic process | 226/8552 | 396/18723 | 2.81e-06 | 3.21e-05 | 226 |
GO:00060069 | Esophagus | ESCC | glucose metabolic process | 119/8552 | 196/18723 | 1.51e-05 | 1.36e-04 | 119 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa01200 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa00010 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa04066 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa04919 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa05230 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa04152 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa04922 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa00051 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa01230 | Colorectum | AD | Biosynthesis of amino acids | 28/2092 | 75/8465 | 9.99e-03 | 3.89e-02 | 2.48e-02 | 28 |
hsa012001 | Colorectum | AD | Carbon metabolism | 55/2092 | 115/8465 | 5.53e-08 | 8.42e-07 | 5.37e-07 | 55 |
hsa000101 | Colorectum | AD | Glycolysis / Gluconeogenesis | 34/2092 | 67/8465 | 3.63e-06 | 4.34e-05 | 2.77e-05 | 34 |
hsa040661 | Colorectum | AD | HIF-1 signaling pathway | 48/2092 | 109/8465 | 7.25e-06 | 7.84e-05 | 5.00e-05 | 48 |
hsa049191 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa052301 | Colorectum | AD | Central carbon metabolism in cancer | 33/2092 | 70/8465 | 3.61e-05 | 3.19e-04 | 2.03e-04 | 33 |
hsa041521 | Colorectum | AD | AMPK signaling pathway | 47/2092 | 121/8465 | 3.74e-04 | 2.82e-03 | 1.80e-03 | 47 |
hsa049221 | Colorectum | AD | Glucagon signaling pathway | 41/2092 | 107/8465 | 1.18e-03 | 7.75e-03 | 4.94e-03 | 41 |
hsa000511 | Colorectum | AD | Fructose and mannose metabolism | 17/2092 | 34/8465 | 1.25e-03 | 8.02e-03 | 5.12e-03 | 17 |
hsa012301 | Colorectum | AD | Biosynthesis of amino acids | 28/2092 | 75/8465 | 9.99e-03 | 3.89e-02 | 2.48e-02 | 28 |
hsa049222 | Colorectum | SER | Glucagon signaling pathway | 38/1580 | 107/8465 | 2.57e-05 | 3.28e-04 | 2.38e-04 | 38 |
hsa012002 | Colorectum | SER | Carbon metabolism | 40/1580 | 115/8465 | 2.77e-05 | 3.41e-04 | 2.47e-04 | 40 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PFKL | SNV | Missense_Mutation | rs532660507 | c.2093N>A | p.Arg698Gln | p.R698Q | P17858 | protein_coding | tolerated(0.12) | benign(0.058) | TCGA-OL-A5S0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | CR |
PFKL | SNV | Missense_Mutation | rs372280224 | c.868N>A | p.Asp290Asn | p.D290N | P17858 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PFKL | SNV | Missense_Mutation | c.1048N>A | p.Glu350Lys | p.E350K | P17858 | protein_coding | tolerated(0.19) | benign(0.014) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PFKL | SNV | Missense_Mutation | novel | c.2131N>A | p.Gly711Ser | p.G711S | P17858 | protein_coding | deleterious(0) | possibly_damaging(0.839) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PFKL | SNV | Missense_Mutation | novel | c.95N>T | p.Ala32Val | p.A32V | P17858 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-VS-A8QA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PFKL | SNV | Missense_Mutation | c.1765N>A | p.Ala589Thr | p.A589T | P17858 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
PFKL | SNV | Missense_Mutation | rs746385697 | c.911N>T | p.Thr304Met | p.T304M | P17858 | protein_coding | deleterious(0) | possibly_damaging(0.652) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PFKL | SNV | Missense_Mutation | novel | c.925N>A | p.Asp309Asn | p.D309N | P17858 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PFKL | SNV | Missense_Mutation | c.966G>A | p.Met322Ile | p.M322I | P17858 | protein_coding | tolerated(0.3) | benign(0.001) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PFKL | SNV | Missense_Mutation | rs144853438 | c.1876C>T | p.Arg626Trp | p.R626W | P17858 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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