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Gene: NR4A2 |
Gene summary for NR4A2 |
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Gene information | Species | Human | Gene symbol | NR4A2 | Gene ID | 4929 |
Gene name | nuclear receptor subfamily 4 group A member 2 | |
Gene Alias | HZF-3 | |
Cytomap | 2q24.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | F1D8N6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4929 | NR4A2 | GSM4909282 | Human | Breast | IDC | 2.79e-12 | 6.24e-01 | -0.0288 |
4929 | NR4A2 | GSM4909286 | Human | Breast | IDC | 5.57e-04 | 1.19e-01 | 0.1081 |
4929 | NR4A2 | GSM4909291 | Human | Breast | IDC | 2.96e-03 | 3.82e-01 | 0.1753 |
4929 | NR4A2 | GSM4909294 | Human | Breast | IDC | 2.27e-02 | -2.11e-01 | 0.2022 |
4929 | NR4A2 | GSM4909297 | Human | Breast | IDC | 7.30e-03 | -1.60e-01 | 0.1517 |
4929 | NR4A2 | GSM4909298 | Human | Breast | IDC | 2.71e-02 | -2.30e-01 | 0.1551 |
4929 | NR4A2 | GSM4909304 | Human | Breast | IDC | 2.07e-02 | -2.05e-01 | 0.1636 |
4929 | NR4A2 | GSM4909308 | Human | Breast | IDC | 2.11e-34 | 7.85e-01 | 0.158 |
4929 | NR4A2 | GSM4909311 | Human | Breast | IDC | 6.16e-11 | -2.79e-01 | 0.1534 |
4929 | NR4A2 | GSM4909313 | Human | Breast | IDC | 3.13e-02 | 3.03e-01 | 0.0391 |
4929 | NR4A2 | GSM4909319 | Human | Breast | IDC | 1.90e-09 | -2.39e-01 | 0.1563 |
4929 | NR4A2 | GSM4909320 | Human | Breast | IDC | 4.54e-03 | -3.17e-01 | 0.1575 |
4929 | NR4A2 | GSM4909321 | Human | Breast | IDC | 3.04e-03 | -2.14e-01 | 0.1559 |
4929 | NR4A2 | brca1 | Human | Breast | Precancer | 4.83e-06 | -2.88e-01 | -0.0338 |
4929 | NR4A2 | brca2 | Human | Breast | Precancer | 1.56e-05 | -2.67e-01 | -0.024 |
4929 | NR4A2 | brca3 | Human | Breast | Precancer | 1.10e-04 | -2.82e-01 | -0.0263 |
4929 | NR4A2 | brca10 | Human | Breast | Precancer | 1.20e-05 | -2.88e-01 | -0.0029 |
4929 | NR4A2 | NCCBC14 | Human | Breast | DCIS | 1.73e-06 | -2.86e-01 | 0.2021 |
4929 | NR4A2 | NCCBC3 | Human | Breast | DCIS | 1.44e-04 | -2.62e-01 | 0.1198 |
4929 | NR4A2 | NCCBC5 | Human | Breast | DCIS | 2.45e-04 | -1.96e-01 | 0.2046 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00362938 | Lung | IAC | response to decreased oxygen levels | 64/2061 | 322/18723 | 1.87e-06 | 8.87e-05 | 64 |
GO:00069798 | Lung | IAC | response to oxidative stress | 82/2061 | 446/18723 | 1.99e-06 | 9.18e-05 | 82 |
GO:00600706 | Lung | IAC | canonical Wnt signaling pathway | 61/2061 | 303/18723 | 2.09e-06 | 9.45e-05 | 61 |
GO:19016537 | Lung | IAC | cellular response to peptide | 69/2061 | 359/18723 | 2.62e-06 | 1.14e-04 | 69 |
GO:00016668 | Lung | IAC | response to hypoxia | 61/2061 | 307/18723 | 3.26e-06 | 1.39e-04 | 61 |
GO:00709978 | Lung | IAC | neuron death | 68/2061 | 361/18723 | 6.32e-06 | 2.32e-04 | 68 |
GO:00621978 | Lung | IAC | cellular response to chemical stress | 64/2061 | 337/18723 | 8.92e-06 | 3.01e-04 | 64 |
GO:00434347 | Lung | IAC | response to peptide hormone | 75/2061 | 414/18723 | 9.29e-06 | 3.06e-04 | 75 |
GO:00713756 | Lung | IAC | cellular response to peptide hormone stimulus | 57/2061 | 290/18723 | 9.48e-06 | 3.11e-04 | 57 |
GO:00704828 | Lung | IAC | response to oxygen levels | 65/2061 | 347/18723 | 1.21e-05 | 3.64e-04 | 65 |
GO:00714968 | Lung | IAC | cellular response to external stimulus | 60/2061 | 320/18723 | 2.50e-05 | 6.76e-04 | 60 |
GO:00316687 | Lung | IAC | cellular response to extracellular stimulus | 48/2061 | 246/18723 | 5.62e-05 | 1.24e-03 | 48 |
GO:00345998 | Lung | IAC | cellular response to oxidative stress | 54/2061 | 288/18723 | 6.20e-05 | 1.35e-03 | 54 |
GO:19012148 | Lung | IAC | regulation of neuron death | 58/2061 | 319/18723 | 8.28e-05 | 1.69e-03 | 58 |
GO:00615646 | Lung | IAC | axon development | 78/2061 | 467/18723 | 1.12e-04 | 2.15e-03 | 78 |
GO:00074096 | Lung | IAC | axonogenesis | 71/2061 | 418/18723 | 1.33e-04 | 2.48e-03 | 71 |
GO:0007585 | Lung | IAC | respiratory gaseous exchange by respiratory system | 18/2061 | 68/18723 | 2.99e-04 | 4.82e-03 | 18 |
GO:00454443 | Lung | IAC | fat cell differentiation | 42/2061 | 229/18723 | 6.19e-04 | 8.50e-03 | 42 |
GO:0001764 | Lung | IAC | neuron migration | 31/2061 | 156/18723 | 7.89e-04 | 1.02e-02 | 31 |
GO:00219552 | Lung | IAC | central nervous system neuron axonogenesis | 11/2061 | 35/18723 | 9.48e-04 | 1.15e-02 | 11 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0492812 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa0492813 | Cervix | CC | Parathyroid hormone synthesis, secretion and action | 27/1267 | 106/8465 | 3.12e-03 | 1.19e-02 | 7.03e-03 | 27 |
hsa0492816 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa0492817 | Esophagus | ESCC | Parathyroid hormone synthesis, secretion and action | 66/4205 | 106/8465 | 5.86e-03 | 1.47e-02 | 7.51e-03 | 66 |
hsa0492810 | Lung | IAC | Parathyroid hormone synthesis, secretion and action | 26/1053 | 106/8465 | 4.34e-04 | 4.03e-03 | 2.68e-03 | 26 |
hsa0492811 | Lung | IAC | Parathyroid hormone synthesis, secretion and action | 26/1053 | 106/8465 | 4.34e-04 | 4.03e-03 | 2.68e-03 | 26 |
hsa0492814 | Prostate | BPH | Parathyroid hormone synthesis, secretion and action | 33/1718 | 106/8465 | 5.30e-03 | 1.75e-02 | 1.08e-02 | 33 |
hsa0492815 | Prostate | BPH | Parathyroid hormone synthesis, secretion and action | 33/1718 | 106/8465 | 5.30e-03 | 1.75e-02 | 1.08e-02 | 33 |
hsa0492822 | Prostate | Tumor | Parathyroid hormone synthesis, secretion and action | 35/1791 | 106/8465 | 2.89e-03 | 1.07e-02 | 6.67e-03 | 35 |
hsa0492832 | Prostate | Tumor | Parathyroid hormone synthesis, secretion and action | 35/1791 | 106/8465 | 2.89e-03 | 1.07e-02 | 6.67e-03 | 35 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NR4A2 | SNV | Missense_Mutation | c.1028G>T | p.Gly343Val | p.G343V | P43354 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A2-A0EQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
NR4A2 | SNV | Missense_Mutation | novel | c.872N>C | p.Val291Ala | p.V291A | P43354 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
NR4A2 | deletion | Frame_Shift_Del | c.430delG | p.Asp144ThrfsTer19 | p.D144Tfs*19 | P43354 | protein_coding | TCGA-E2-A1IF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |||
NR4A2 | SNV | Missense_Mutation | c.833G>T | p.Arg278Leu | p.R278L | P43354 | protein_coding | deleterious(0.01) | probably_damaging(0.92) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NR4A2 | SNV | Missense_Mutation | c.52G>A | p.Ala18Thr | p.A18T | P43354 | protein_coding | deleterious(0.03) | possibly_damaging(0.656) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NR4A2 | SNV | Missense_Mutation | c.16N>A | p.Ala6Thr | p.A6T | P43354 | protein_coding | tolerated(0.33) | benign(0.339) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
NR4A2 | SNV | Missense_Mutation | c.866N>A | p.Arg289His | p.R289H | P43354 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NR4A2 | SNV | Missense_Mutation | novel | c.503C>T | p.Thr168Met | p.T168M | P43354 | protein_coding | deleterious(0.03) | benign(0.11) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NR4A2 | SNV | Missense_Mutation | novel | c.1145N>G | p.Leu382Arg | p.L382R | P43354 | protein_coding | deleterious(0.01) | benign(0.436) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
NR4A2 | SNV | Missense_Mutation | novel | c.214N>A | p.Asp72Asn | p.D72N | P43354 | protein_coding | tolerated(0.07) | probably_damaging(0.932) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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