Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: NDUFAF2

Gene summary for NDUFAF2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

NDUFAF2

Gene ID

91942

Gene nameNADH:ubiquinone oxidoreductase complex assembly factor 2
Gene AliasB17.2L
Cytomap5q12.1
Gene Typeprotein-coding
GO ID

GO:0001678

UniProtAcc

A0A0S2Z5U1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
91942NDUFAF2HTA11_3410_2000001011HumanColorectumAD1.64e-12-5.33e-010.0155
91942NDUFAF2HTA11_2487_2000001011HumanColorectumSER3.03e-04-4.95e-01-0.1808
91942NDUFAF2HTA11_3361_2000001011HumanColorectumAD1.23e-03-5.56e-01-0.1207
91942NDUFAF2HTA11_696_2000001011HumanColorectumAD4.54e-16-3.99e-01-0.1464
91942NDUFAF2HTA11_866_2000001011HumanColorectumAD8.48e-11-4.09e-01-0.1001
91942NDUFAF2HTA11_5212_2000001011HumanColorectumAD2.25e-02-6.60e-01-0.2061
91942NDUFAF2HTA11_546_2000001011HumanColorectumAD4.99e-03-5.36e-01-0.0842
91942NDUFAF2HTA11_866_3004761011HumanColorectumAD4.61e-08-5.13e-010.096
91942NDUFAF2HTA11_10711_2000001011HumanColorectumAD5.87e-03-4.96e-010.0338
91942NDUFAF2HTA11_7696_3000711011HumanColorectumAD7.78e-20-4.64e-010.0674
91942NDUFAF2HTA11_99999970781_79442HumanColorectumMSS5.53e-13-4.56e-010.294
91942NDUFAF2HTA11_99999971662_82457HumanColorectumMSS8.33e-08-3.28e-010.3859
91942NDUFAF2HTA11_99999974143_84620HumanColorectumMSS1.01e-14-4.73e-010.3005
91942NDUFAF2A001-C-207HumanColorectumFAP2.27e-03-3.62e-010.1278
91942NDUFAF2A015-C-203HumanColorectumFAP1.34e-29-4.92e-01-0.1294
91942NDUFAF2A015-C-204HumanColorectumFAP8.49e-06-4.03e-01-0.0228
91942NDUFAF2A002-C-201HumanColorectumFAP6.93e-16-5.70e-010.0324
91942NDUFAF2A002-C-203HumanColorectumFAP2.56e-04-2.04e-010.2786
91942NDUFAF2A001-C-119HumanColorectumFAP3.47e-08-5.31e-01-0.1557
91942NDUFAF2A001-C-108HumanColorectumFAP6.48e-16-3.87e-01-0.0272
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00466762SkincSCCnegative regulation of insulin secretion17/486438/187239.41e-034.25e-0217
GO:0033108111ThyroidPTCmitochondrial respiratory chain complex assembly65/596893/187235.60e-143.21e-1265
GO:0010257111ThyroidPTCNADH dehydrogenase complex assembly43/596857/187231.73e-116.81e-1043
GO:0032981111ThyroidPTCmitochondrial respiratory chain complex I assembly43/596857/187231.73e-116.81e-1043
GO:0009743113ThyroidPTCresponse to carbohydrate111/5968253/187233.77e-053.48e-04111
GO:0034284112ThyroidPTCresponse to monosaccharide99/5968225/187238.42e-057.03e-0499
GO:19049507ThyroidPTCnegative regulation of establishment of protein localization61/5968131/187233.01e-042.12e-0361
GO:0009746112ThyroidPTCresponse to hexose94/5968219/187233.62e-042.45e-0394
GO:00512246ThyroidPTCnegative regulation of protein transport59/5968127/187234.04e-042.71e-0359
GO:0009749111ThyroidPTCresponse to glucose91/5968212/187234.44e-042.95e-0391
GO:0001678110ThyroidPTCcellular glucose homeostasis72/5968172/187233.58e-031.73e-0272
GO:0033500110ThyroidPTCcarbohydrate homeostasis103/5968259/187234.19e-031.99e-02103
GO:0071322111ThyroidPTCcellular response to carbohydrate stimulus68/5968163/187235.00e-032.31e-0268
GO:0042593110ThyroidPTCglucose homeostasis102/5968258/187235.34e-032.46e-02102
GO:00510518ThyroidPTCnegative regulation of transport176/5968470/187235.44e-032.49e-02176
GO:0071333110ThyroidPTCcellular response to glucose stimulus63/5968151/187236.69e-032.89e-0263
GO:007169216ThyroidPTCprotein localization to extracellular region139/5968368/187238.95e-033.72e-02139
GO:0071331110ThyroidPTCcellular response to hexose stimulus63/5968153/187239.35e-033.85e-0263
GO:0071326110ThyroidPTCcellular response to monosaccharide stimulus63/5968154/187231.10e-024.39e-0263
GO:000930618ThyroidPTCprotein secretion135/5968359/187231.16e-024.58e-02135
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04714ColorectumADThermogenesis120/2092232/84652.76e-191.16e-177.37e-18120
hsa047141ColorectumADThermogenesis120/2092232/84652.76e-191.16e-177.37e-18120
hsa047142ColorectumSERThermogenesis106/1580232/84651.15e-216.34e-204.61e-20106
hsa047143ColorectumSERThermogenesis106/1580232/84651.15e-216.34e-204.61e-20106
hsa047144ColorectumMSSThermogenesis113/1875232/84651.52e-194.62e-182.83e-18113
hsa047145ColorectumMSSThermogenesis113/1875232/84651.52e-194.62e-182.83e-18113
hsa047148ColorectumFAPThermogenesis70/1404232/84651.38e-073.08e-061.87e-0670
hsa047149ColorectumFAPThermogenesis70/1404232/84651.38e-073.08e-061.87e-0670
hsa04714211EsophagusESCCThermogenesis163/4205232/84659.22e-111.14e-095.86e-10163
hsa04714310EsophagusESCCThermogenesis163/4205232/84659.22e-111.14e-095.86e-10163
hsa0471414LiverCirrhoticThermogenesis121/2530232/84655.70e-131.36e-118.36e-12121
hsa0471415LiverCirrhoticThermogenesis121/2530232/84655.70e-131.36e-118.36e-12121
hsa0471422LiverHCCThermogenesis170/4020232/84655.36e-162.25e-141.25e-14170
hsa0471432LiverHCCThermogenesis170/4020232/84655.36e-162.25e-141.25e-14170
hsa0471430Oral cavityOSCCThermogenesis138/3704232/84657.67e-074.35e-062.22e-06138
hsa04714113Oral cavityOSCCThermogenesis138/3704232/84657.67e-074.35e-062.22e-06138
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
NDUFAF2SNVMissense_Mutationnovelc.222G>Tp.Trp74Cysp.W74CQ8N183protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AR-A24W-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyletrozoleSD
NDUFAF2SNVMissense_Mutationrs769323668c.25N>Tp.Arg9Cysp.R9CQ8N183protein_codingdeleterious(0)benign(0.011)TCGA-A6-4105-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
NDUFAF2SNVMissense_Mutationc.410N>Gp.Tyr137Cysp.Y137CQ8N183protein_codingtolerated(0.08)benign(0.43)TCGA-AA-3494-01Colorectumcolon adenocarcinomaMale<65III/IVChemotherapyfolinicPR
NDUFAF2SNVMissense_Mutationnovelc.134N>Gp.Thr45Serp.T45SQ8N183protein_codingtolerated(0.38)possibly_damaging(0.54)TCGA-AA-3666-01Colorectumcolon adenocarcinomaMale>=65III/IVUnknownUnknownPD
NDUFAF2SNVMissense_Mutationc.128N>Ap.Gly43Glup.G43EQ8N183protein_codingdeleterious(0)probably_damaging(1)TCGA-AA-3870-01Colorectumcolon adenocarcinomaFemale>=65III/IVChemotherapyfolinicCR
NDUFAF2deletionFrame_Shift_Delc.184_185delNNp.Tyr62Terp.Y62*Q8N183protein_codingTCGA-AA-3496-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
NDUFAF2SNVMissense_Mutationc.303N>Cp.Lys101Asnp.K101NQ8N183protein_codingdeleterious(0)possibly_damaging(0.614)TCGA-AP-A059-01Endometriumuterine corpus endometrioid carcinomaFemale>=65I/IIUnknownUnknownSD
NDUFAF2SNVMissense_Mutationnovelc.477N>Tp.Trp159Cysp.W159CQ8N183protein_codingdeleterious(0)probably_damaging(0.998)TCGA-AP-A1DK-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
NDUFAF2SNVMissense_Mutationnovelc.117N>Tp.Lys39Asnp.K39NQ8N183protein_codingdeleterious(0.01)possibly_damaging(0.681)TCGA-AP-A1DV-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
NDUFAF2SNVMissense_Mutationnovelc.145N>Gp.Lys49Glup.K49EQ8N183protein_codingdeleterious(0.04)benign(0.391)TCGA-DD-AADQ-01Liverliver hepatocellular carcinomaMale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
91942NDUFAF2ENZYMEinhibitorCHEMBL1703METFORMIN HYDROCHLORIDE
91942NDUFAF2ENZYMEinhibitorCHEMBL3545135NV-128
91942NDUFAF2ENZYMEinhibitorCHEMBL3545320ME-344
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