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Gene: MYADM |
Gene summary for MYADM |
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Gene information | Species | Human | Gene symbol | MYADM | Gene ID | 91663 |
Gene name | myeloid associated differentiation marker | |
Gene Alias | SB135 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A0A024R4N0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
91663 | MYADM | CA_HPV_2 | Human | Cervix | CC | 2.85e-08 | 5.29e-01 | 0.0391 |
91663 | MYADM | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 2.38e-02 | -2.78e-01 | 0.0208 |
91663 | MYADM | N_HPV_1 | Human | Cervix | N_HPV | 9.61e-03 | 3.15e-01 | 0.0079 |
91663 | MYADM | CCI_1 | Human | Cervix | CC | 1.25e-03 | -4.65e-01 | 0.528 |
91663 | MYADM | CCI_2 | Human | Cervix | CC | 2.44e-05 | -4.85e-01 | 0.5249 |
91663 | MYADM | CCI_3 | Human | Cervix | CC | 2.45e-08 | -4.85e-01 | 0.516 |
91663 | MYADM | CCII_1 | Human | Cervix | CC | 1.91e-09 | -4.74e-01 | 0.3249 |
91663 | MYADM | Tumor | Human | Cervix | CC | 6.17e-26 | -4.85e-01 | 0.1241 |
91663 | MYADM | sample1 | Human | Cervix | CC | 3.13e-07 | -4.63e-01 | 0.0959 |
91663 | MYADM | sample3 | Human | Cervix | CC | 7.30e-28 | -4.84e-01 | 0.1387 |
91663 | MYADM | H2 | Human | Cervix | HSIL_HPV | 1.55e-03 | -3.41e-01 | 0.0632 |
91663 | MYADM | L1 | Human | Cervix | CC | 7.01e-06 | -3.75e-01 | 0.0802 |
91663 | MYADM | T1 | Human | Cervix | CC | 1.16e-22 | -4.85e-01 | 0.0918 |
91663 | MYADM | T3 | Human | Cervix | CC | 1.05e-26 | -4.85e-01 | 0.1389 |
91663 | MYADM | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.38e-04 | 1.73e-01 | 0.0155 |
91663 | MYADM | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.37e-04 | 3.64e-01 | 0.0216 |
91663 | MYADM | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.11e-07 | 3.26e-01 | -0.0811 |
91663 | MYADM | HTA11_78_2000001011 | Human | Colorectum | AD | 1.31e-03 | 2.17e-01 | -0.1088 |
91663 | MYADM | HTA11_347_2000001011 | Human | Colorectum | AD | 3.38e-17 | 5.08e-01 | -0.1954 |
91663 | MYADM | HTA11_411_2000001011 | Human | Colorectum | SER | 2.08e-03 | 6.35e-01 | -0.2602 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00315892 | Colorectum | MSS | cell-substrate adhesion | 104/3467 | 363/18723 | 1.35e-06 | 4.51e-05 | 104 |
GO:00344462 | Colorectum | MSS | substrate adhesion-dependent cell spreading | 39/3467 | 108/18723 | 1.15e-05 | 2.71e-04 | 39 |
GO:00105632 | Colorectum | MSS | negative regulation of phosphorus metabolic process | 118/3467 | 442/18723 | 1.18e-05 | 2.77e-04 | 118 |
GO:00459362 | Colorectum | MSS | negative regulation of phosphate metabolic process | 117/3467 | 441/18723 | 1.74e-05 | 3.84e-04 | 117 |
GO:19000242 | Colorectum | MSS | regulation of substrate adhesion-dependent cell spreading | 24/3467 | 57/18723 | 3.16e-05 | 6.29e-04 | 24 |
GO:00423262 | Colorectum | MSS | negative regulation of phosphorylation | 103/3467 | 385/18723 | 3.76e-05 | 7.17e-04 | 103 |
GO:19000262 | Colorectum | MSS | positive regulation of substrate adhesion-dependent cell spreading | 19/3467 | 41/18723 | 4.24e-05 | 7.94e-04 | 19 |
GO:00019332 | Colorectum | MSS | negative regulation of protein phosphorylation | 93/3467 | 342/18723 | 4.54e-05 | 8.35e-04 | 93 |
GO:00322722 | Colorectum | MSS | negative regulation of protein polymerization | 30/3467 | 80/18723 | 5.05e-05 | 9.09e-04 | 30 |
GO:00107692 | Colorectum | MSS | regulation of cell morphogenesis involved in differentiation | 34/3467 | 96/18723 | 6.43e-05 | 1.12e-03 | 34 |
GO:00610282 | Colorectum | MSS | establishment of endothelial barrier | 20/3467 | 46/18723 | 8.26e-05 | 1.35e-03 | 20 |
GO:00107702 | Colorectum | MSS | positive regulation of cell morphogenesis involved in differentiation | 29/3467 | 79/18723 | 1.04e-04 | 1.63e-03 | 29 |
GO:00308372 | Colorectum | MSS | negative regulation of actin filament polymerization | 25/3467 | 65/18723 | 1.30e-04 | 1.99e-03 | 25 |
GO:00107202 | Colorectum | MSS | positive regulation of cell development | 81/3467 | 298/18723 | 1.38e-04 | 2.06e-03 | 81 |
GO:00457852 | Colorectum | MSS | positive regulation of cell adhesion | 110/3467 | 437/18723 | 2.94e-04 | 3.87e-03 | 110 |
GO:00313332 | Colorectum | MSS | negative regulation of protein-containing complex assembly | 43/3467 | 141/18723 | 3.84e-04 | 4.85e-03 | 43 |
GO:19029042 | Colorectum | MSS | negative regulation of supramolecular fiber organization | 49/3467 | 167/18723 | 4.30e-04 | 5.23e-03 | 49 |
GO:00514942 | Colorectum | MSS | negative regulation of cytoskeleton organization | 47/3467 | 163/18723 | 8.45e-04 | 8.71e-03 | 47 |
GO:00018851 | Colorectum | MSS | endothelial cell development | 22/3467 | 64/18723 | 1.86e-03 | 1.64e-02 | 22 |
GO:00031581 | Colorectum | MSS | endothelium development | 38/3467 | 136/18723 | 4.53e-03 | 3.19e-02 | 38 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYADM | SNV | Missense_Mutation | c.884N>T | p.Ala295Val | p.A295V | Q96S97 | protein_coding | tolerated(0.08) | possibly_damaging(0.589) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
MYADM | insertion | Frame_Shift_Ins | novel | c.148_149insACCACACCCGG | p.Ala50AspfsTer33 | p.A50Dfs*33 | Q96S97 | protein_coding | TCGA-B6-A0RE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MYADM | SNV | Missense_Mutation | c.7G>A | p.Val3Met | p.V3M | Q96S97 | protein_coding | tolerated_low_confidence(0.17) | benign(0.295) | TCGA-C5-A1MQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
MYADM | SNV | Missense_Mutation | novel | c.415G>A | p.Ala139Thr | p.A139T | Q96S97 | protein_coding | tolerated(0.33) | possibly_damaging(0.68) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MYADM | SNV | Missense_Mutation | rs775841521 | c.398N>T | p.Ser133Leu | p.S133L | Q96S97 | protein_coding | tolerated(0.63) | benign(0.092) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
MYADM | SNV | Missense_Mutation | novel | c.136N>G | p.Ser46Ala | p.S46A | Q96S97 | protein_coding | tolerated(0.13) | probably_damaging(0.989) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MYADM | SNV | Missense_Mutation | c.410N>T | p.Ala137Val | p.A137V | Q96S97 | protein_coding | tolerated(0.1) | possibly_damaging(0.657) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MYADM | SNV | Missense_Mutation | rs776582147 | c.899N>T | p.Thr300Met | p.T300M | Q96S97 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MYADM | SNV | Missense_Mutation | c.584N>G | p.Asn195Ser | p.N195S | Q96S97 | protein_coding | tolerated(0.63) | benign(0) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MYADM | SNV | Missense_Mutation | c.805N>A | p.Gly269Ser | p.G269S | Q96S97 | protein_coding | deleterious(0.01) | benign(0.164) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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