![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MTPN |
Gene summary for MTPN |
![]() |
Gene information | Species | Human | Gene symbol | MTPN | Gene ID | 136319 |
Gene name | myotrophin | |
Gene Alias | GCDP | |
Cytomap | 7q33 | |
Gene Type | protein-coding | GO ID | GO:0001558 | UniProtAcc | P58546 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
136319 | MTPN | CA_HPV_1 | Human | Cervix | CC | 4.38e-12 | -5.54e-02 | 0.0264 |
136319 | MTPN | N_HPV_1 | Human | Cervix | N_HPV | 2.87e-02 | -1.20e-01 | 0.0079 |
136319 | MTPN | CCI_1 | Human | Cervix | CC | 4.69e-04 | -6.18e-01 | 0.528 |
136319 | MTPN | CCI_3 | Human | Cervix | CC | 3.06e-06 | -6.13e-01 | 0.516 |
136319 | MTPN | CCII_1 | Human | Cervix | CC | 2.24e-16 | -7.36e-01 | 0.3249 |
136319 | MTPN | H2 | Human | Cervix | HSIL_HPV | 2.33e-07 | -3.52e-01 | 0.0632 |
136319 | MTPN | L1 | Human | Cervix | CC | 2.05e-04 | -2.62e-01 | 0.0802 |
136319 | MTPN | T1 | Human | Cervix | CC | 1.80e-03 | -4.03e-01 | 0.0918 |
136319 | MTPN | T3 | Human | Cervix | CC | 4.89e-03 | -1.62e-01 | 0.1389 |
136319 | MTPN | AEH-subject1 | Human | Endometrium | AEH | 1.00e-11 | -3.34e-01 | -0.3059 |
136319 | MTPN | AEH-subject2 | Human | Endometrium | AEH | 3.90e-11 | -2.58e-01 | -0.2525 |
136319 | MTPN | AEH-subject3 | Human | Endometrium | AEH | 3.97e-09 | -2.72e-01 | -0.2576 |
136319 | MTPN | AEH-subject4 | Human | Endometrium | AEH | 7.88e-03 | -1.11e-01 | -0.2657 |
136319 | MTPN | AEH-subject5 | Human | Endometrium | AEH | 2.89e-02 | -1.96e-01 | -0.2953 |
136319 | MTPN | EEC-subject1 | Human | Endometrium | EEC | 1.41e-10 | -3.68e-01 | -0.2682 |
136319 | MTPN | EEC-subject2 | Human | Endometrium | EEC | 2.52e-18 | -4.41e-01 | -0.2607 |
136319 | MTPN | EEC-subject3 | Human | Endometrium | EEC | 2.40e-24 | -2.61e-01 | -0.2525 |
136319 | MTPN | EEC-subject4 | Human | Endometrium | EEC | 5.58e-03 | -2.13e-01 | -0.2571 |
136319 | MTPN | EEC-subject5 | Human | Endometrium | EEC | 1.14e-05 | -2.75e-01 | -0.249 |
136319 | MTPN | GSM5276935 | Human | Endometrium | EEC | 9.56e-06 | -2.85e-01 | -0.123 |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001470615 | Esophagus | ESCC | striated muscle tissue development | 197/8552 | 384/18723 | 1.46e-02 | 4.74e-02 | 197 |
GO:000641712 | Liver | Cirrhotic | regulation of translation | 194/4634 | 468/18723 | 7.28e-16 | 8.79e-14 | 194 |
GO:00224117 | Liver | Cirrhotic | cellular component disassembly | 182/4634 | 443/18723 | 1.59e-14 | 1.54e-12 | 182 |
GO:004325412 | Liver | Cirrhotic | regulation of protein-containing complex assembly | 169/4634 | 428/18723 | 7.40e-12 | 4.99e-10 | 169 |
GO:000701512 | Liver | Cirrhotic | actin filament organization | 171/4634 | 442/18723 | 3.93e-11 | 2.30e-09 | 171 |
GO:190290312 | Liver | Cirrhotic | regulation of supramolecular fiber organization | 148/4634 | 383/18723 | 8.85e-10 | 4.08e-08 | 148 |
GO:003297012 | Liver | Cirrhotic | regulation of actin filament-based process | 152/4634 | 397/18723 | 1.12e-09 | 5.00e-08 | 152 |
GO:003295612 | Liver | Cirrhotic | regulation of actin cytoskeleton organization | 136/4634 | 358/18723 | 1.47e-08 | 5.49e-07 | 136 |
GO:005125812 | Liver | Cirrhotic | protein polymerization | 116/4634 | 297/18723 | 2.87e-08 | 9.78e-07 | 116 |
GO:007149612 | Liver | Cirrhotic | cellular response to external stimulus | 123/4634 | 320/18723 | 3.27e-08 | 1.10e-06 | 123 |
GO:00313337 | Liver | Cirrhotic | negative regulation of protein-containing complex assembly | 64/4634 | 141/18723 | 7.08e-08 | 2.14e-06 | 64 |
GO:011005312 | Liver | Cirrhotic | regulation of actin filament organization | 108/4634 | 278/18723 | 1.17e-07 | 3.32e-06 | 108 |
GO:003227112 | Liver | Cirrhotic | regulation of protein polymerization | 92/4634 | 233/18723 | 4.25e-07 | 9.86e-06 | 92 |
GO:000815412 | Liver | Cirrhotic | actin polymerization or depolymerization | 86/4634 | 218/18723 | 1.04e-06 | 2.13e-05 | 86 |
GO:003004112 | Liver | Cirrhotic | actin filament polymerization | 77/4634 | 191/18723 | 1.41e-06 | 2.79e-05 | 77 |
GO:003253512 | Liver | Cirrhotic | regulation of cellular component size | 135/4634 | 383/18723 | 2.32e-06 | 4.26e-05 | 135 |
GO:00106397 | Liver | Cirrhotic | negative regulation of organelle organization | 124/4634 | 348/18723 | 3.20e-06 | 5.60e-05 | 124 |
GO:003083312 | Liver | Cirrhotic | regulation of actin filament polymerization | 69/4634 | 172/18723 | 5.92e-06 | 9.65e-05 | 69 |
GO:00080647 | Liver | Cirrhotic | regulation of actin polymerization or depolymerization | 74/4634 | 188/18723 | 6.26e-06 | 9.92e-05 | 74 |
GO:00308327 | Liver | Cirrhotic | regulation of actin filament length | 74/4634 | 189/18723 | 7.83e-06 | 1.18e-04 | 74 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MTPN | SNV | Missense_Mutation | novel | c.7G>A | p.Asp3Asn | p.D3N | P58546 | protein_coding | tolerated(0.3) | possibly_damaging(0.649) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
MTPN | SNV | Missense_Mutation | novel | c.229T>G | p.Tyr77Asp | p.Y77D | P58546 | protein_coding | deleterious(0.01) | possibly_damaging(0.814) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MTPN | SNV | Missense_Mutation | c.188N>A | p.Ala63Asp | p.A63D | P58546 | protein_coding | deleterious(0.05) | probably_damaging(0.988) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTPN | SNV | Missense_Mutation | c.310G>A | p.Ala104Thr | p.A104T | P58546 | protein_coding | tolerated(0.34) | probably_damaging(0.934) | TCGA-BG-A0M7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD | |
MTPN | SNV | Missense_Mutation | novel | c.147N>C | p.Glu49Asp | p.E49D | P58546 | protein_coding | tolerated(0.53) | benign(0.007) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MTPN | SNV | Missense_Mutation | c.18N>A | p.Phe6Leu | p.F6L | P58546 | protein_coding | tolerated(1) | benign(0.389) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MTPN | SNV | Missense_Mutation | novel | c.259N>A | p.Leu87Ile | p.L87I | P58546 | protein_coding | deleterious(0.01) | probably_damaging(0.982) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
MTPN | SNV | Missense_Mutation | c.13N>C | p.Glu5Gln | p.E5Q | P58546 | protein_coding | tolerated(0.1) | benign(0.214) | TCGA-60-2708-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
MTPN | SNV | Missense_Mutation | novel | c.232G>A | p.Glu78Lys | p.E78K | P58546 | protein_coding | deleterious(0) | probably_damaging(0.957) | TCGA-KU-A6H7-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MTPN | SNV | Missense_Mutation | c.310N>A | p.Ala104Thr | p.A104T | P58546 | protein_coding | tolerated(0.34) | probably_damaging(0.934) | TCGA-HU-A4H2-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |