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Gene: LEO1 |
Gene summary for LEO1 |
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Gene information | Species | Human | Gene symbol | LEO1 | Gene ID | 123169 |
Gene name | LEO1 homolog, Paf1/RNA polymerase II complex component | |
Gene Alias | RDL | |
Cytomap | 15q21.2 | |
Gene Type | protein-coding | GO ID | GO:0001704 | UniProtAcc | Q8WVC0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
123169 | LEO1 | LZE4T | Human | Esophagus | ESCC | 1.30e-14 | 3.79e-01 | 0.0811 |
123169 | LEO1 | LZE6T | Human | Esophagus | ESCC | 3.53e-03 | 1.40e-01 | 0.0845 |
123169 | LEO1 | P1T-E | Human | Esophagus | ESCC | 3.43e-09 | 3.20e-01 | 0.0875 |
123169 | LEO1 | P2T-E | Human | Esophagus | ESCC | 4.19e-15 | 1.75e-01 | 0.1177 |
123169 | LEO1 | P4T-E | Human | Esophagus | ESCC | 4.07e-29 | 6.53e-01 | 0.1323 |
123169 | LEO1 | P5T-E | Human | Esophagus | ESCC | 3.04e-21 | 4.34e-01 | 0.1327 |
123169 | LEO1 | P8T-E | Human | Esophagus | ESCC | 1.55e-23 | 3.95e-01 | 0.0889 |
123169 | LEO1 | P9T-E | Human | Esophagus | ESCC | 1.25e-11 | 2.85e-01 | 0.1131 |
123169 | LEO1 | P10T-E | Human | Esophagus | ESCC | 3.21e-32 | 5.75e-01 | 0.116 |
123169 | LEO1 | P11T-E | Human | Esophagus | ESCC | 2.97e-08 | 1.97e-01 | 0.1426 |
123169 | LEO1 | P12T-E | Human | Esophagus | ESCC | 4.04e-18 | 3.82e-01 | 0.1122 |
123169 | LEO1 | P15T-E | Human | Esophagus | ESCC | 7.49e-18 | 4.15e-01 | 0.1149 |
123169 | LEO1 | P16T-E | Human | Esophagus | ESCC | 1.27e-17 | 3.13e-01 | 0.1153 |
123169 | LEO1 | P19T-E | Human | Esophagus | ESCC | 4.08e-03 | 5.62e-01 | 0.1662 |
123169 | LEO1 | P20T-E | Human | Esophagus | ESCC | 3.83e-11 | 1.56e-01 | 0.1124 |
123169 | LEO1 | P21T-E | Human | Esophagus | ESCC | 2.40e-16 | 2.81e-01 | 0.1617 |
123169 | LEO1 | P22T-E | Human | Esophagus | ESCC | 4.96e-28 | 2.10e-01 | 0.1236 |
123169 | LEO1 | P23T-E | Human | Esophagus | ESCC | 6.02e-14 | 2.83e-01 | 0.108 |
123169 | LEO1 | P24T-E | Human | Esophagus | ESCC | 1.82e-13 | 3.08e-01 | 0.1287 |
123169 | LEO1 | P26T-E | Human | Esophagus | ESCC | 9.26e-18 | 4.18e-01 | 0.1276 |
Page: 1 2 3 4 5 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000170612 | Thyroid | ATC | endoderm formation | 32/6293 | 54/18723 | 9.72e-05 | 7.10e-04 | 32 |
GO:000749222 | Thyroid | ATC | endoderm development | 42/6293 | 77/18723 | 1.24e-04 | 8.82e-04 | 42 |
GO:000170414 | Thyroid | ATC | formation of primary germ layer | 60/6293 | 121/18723 | 1.96e-04 | 1.31e-03 | 60 |
GO:003296814 | Thyroid | ATC | positive regulation of transcription elongation from RNA polymerase II promoter | 11/6293 | 13/18723 | 2.30e-04 | 1.49e-03 | 11 |
GO:000651314 | Thyroid | ATC | protein monoubiquitination | 35/6293 | 67/18723 | 1.26e-03 | 6.58e-03 | 35 |
GO:003144211 | Thyroid | ATC | positive regulation of mRNA 3'-end processing | 9/6293 | 11/18723 | 1.46e-03 | 7.47e-03 | 9 |
GO:1903706112 | Thyroid | ATC | regulation of hemopoiesis | 148/6293 | 367/18723 | 3.87e-03 | 1.68e-02 | 148 |
GO:0045637113 | Thyroid | ATC | regulation of myeloid cell differentiation | 89/6293 | 210/18723 | 4.75e-03 | 1.96e-02 | 89 |
GO:00103905 | Thyroid | ATC | histone monoubiquitination | 16/6293 | 29/18723 | 1.37e-02 | 4.77e-02 | 16 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LEO1 | SNV | Missense_Mutation | c.1512N>A | p.Met504Ile | p.M504I | Q8WVC0 | protein_coding | tolerated(0.08) | possibly_damaging(0.69) | TCGA-AN-A0FT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LEO1 | SNV | Missense_Mutation | novel | c.43N>A | p.Glu15Lys | p.E15K | Q8WVC0 | protein_coding | deleterious_low_confidence(0.01) | benign(0.031) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LEO1 | SNV | Missense_Mutation | c.68C>T | p.Ser23Phe | p.S23F | Q8WVC0 | protein_coding | tolerated_low_confidence(0.1) | probably_damaging(0.991) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
LEO1 | deletion | Frame_Shift_Del | novel | c.233delN | p.Asp78ValfsTer27 | p.D78Vfs*27 | Q8WVC0 | protein_coding | TCGA-A7-A3J0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | anastrazole | SD | ||
LEO1 | insertion | Nonsense_Mutation | novel | c.144_145insATTAATTATATTTTGATCCTATCTTCTTAGCTTAAATATGAGGGCA | p.Glu49IlefsTer10 | p.E49Ifs*10 | Q8WVC0 | protein_coding | TCGA-A8-A0A1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
LEO1 | SNV | Missense_Mutation | c.1168N>C | p.Asp390His | p.D390H | Q8WVC0 | protein_coding | deleterious(0.04) | probably_damaging(0.913) | TCGA-LP-A4AW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
LEO1 | SNV | Missense_Mutation | c.1033C>G | p.Gln345Glu | p.Q345E | Q8WVC0 | protein_coding | tolerated(0.86) | benign(0.003) | TCGA-LP-A7HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
LEO1 | SNV | Missense_Mutation | c.1505G>C | p.Arg502Thr | p.R502T | Q8WVC0 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
LEO1 | SNV | Missense_Mutation | rs767042967 | c.862N>T | p.Arg288Cys | p.R288C | Q8WVC0 | protein_coding | deleterious(0.01) | possibly_damaging(0.543) | TCGA-A6-6654-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
LEO1 | SNV | Missense_Mutation | rs751561202 | c.1595N>A | p.Arg532His | p.R532H | Q8WVC0 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-A6-6782-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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