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Gene: HDAC8 |
Gene summary for HDAC8 |
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Gene information | Species | Human | Gene symbol | HDAC8 | Gene ID | 55869 |
Gene name | histone deacetylase 8 | |
Gene Alias | CDA07 | |
Cytomap | Xq13.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9BY41 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55869 | HDAC8 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.23e-13 | -4.85e-01 | 0.0155 |
55869 | HDAC8 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.21e-07 | -5.89e-01 | -0.1808 |
55869 | HDAC8 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.79e-03 | -5.11e-01 | -0.1207 |
55869 | HDAC8 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.87e-11 | -3.90e-01 | -0.1464 |
55869 | HDAC8 | HTA11_866_2000001011 | Human | Colorectum | AD | 7.37e-03 | -2.37e-01 | -0.1001 |
55869 | HDAC8 | HTA11_5212_2000001011 | Human | Colorectum | AD | 3.62e-02 | -5.87e-01 | -0.2061 |
55869 | HDAC8 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.34e-08 | -4.52e-01 | 0.096 |
55869 | HDAC8 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.54e-03 | -6.62e-01 | 0.0528 |
55869 | HDAC8 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.09e-02 | -2.93e-01 | 0.0674 |
55869 | HDAC8 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.95e-11 | -4.49e-01 | 0.294 |
55869 | HDAC8 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 5.58e-06 | 6.94e-01 | 0.281 |
55869 | HDAC8 | A015-C-203 | Human | Colorectum | FAP | 3.60e-30 | -4.46e-01 | -0.1294 |
55869 | HDAC8 | A015-C-204 | Human | Colorectum | FAP | 1.89e-05 | -3.69e-01 | -0.0228 |
55869 | HDAC8 | A014-C-040 | Human | Colorectum | FAP | 5.42e-06 | -5.20e-01 | -0.1184 |
55869 | HDAC8 | A002-C-201 | Human | Colorectum | FAP | 1.70e-11 | -2.76e-01 | 0.0324 |
55869 | HDAC8 | A001-C-119 | Human | Colorectum | FAP | 1.28e-11 | -5.75e-01 | -0.1557 |
55869 | HDAC8 | A001-C-108 | Human | Colorectum | FAP | 4.71e-14 | -2.79e-01 | -0.0272 |
55869 | HDAC8 | A002-C-205 | Human | Colorectum | FAP | 1.87e-23 | -4.98e-01 | -0.1236 |
55869 | HDAC8 | A001-C-104 | Human | Colorectum | FAP | 6.45e-05 | -2.50e-01 | 0.0184 |
55869 | HDAC8 | A015-C-005 | Human | Colorectum | FAP | 1.22e-02 | -2.30e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007093211 | Thyroid | ATC | histone H3 deacetylation | 13/6293 | 20/18723 | 4.03e-03 | 1.73e-02 | 13 |
GO:007093311 | Thyroid | ATC | histone H4 deacetylation | 8/6293 | 11/18723 | 9.31e-03 | 3.44e-02 | 8 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04110 | Colorectum | FAP | Cell cycle | 37/1404 | 157/8465 | 1.44e-02 | 4.77e-02 | 2.90e-02 | 37 |
hsa041101 | Colorectum | FAP | Cell cycle | 37/1404 | 157/8465 | 1.44e-02 | 4.77e-02 | 2.90e-02 | 37 |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa052034 | Lung | IAC | Viral carcinogenesis | 43/1053 | 204/8465 | 3.02e-04 | 3.07e-03 | 2.04e-03 | 43 |
hsa041105 | Lung | IAC | Cell cycle | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
hsa0520311 | Lung | IAC | Viral carcinogenesis | 43/1053 | 204/8465 | 3.02e-04 | 3.07e-03 | 2.04e-03 | 43 |
hsa0411012 | Lung | IAC | Cell cycle | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
hsa0520321 | Lung | AIS | Viral carcinogenesis | 37/961 | 204/8465 | 2.49e-03 | 1.49e-02 | 9.55e-03 | 37 |
hsa0520331 | Lung | AIS | Viral carcinogenesis | 37/961 | 204/8465 | 2.49e-03 | 1.49e-02 | 9.55e-03 | 37 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa052038 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0520314 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa0520342 | Oral cavity | EOLP | Viral carcinogenesis | 55/1218 | 204/8465 | 1.54e-06 | 1.34e-05 | 7.92e-06 | 55 |
hsa0411041 | Oral cavity | EOLP | Cell cycle | 42/1218 | 157/8465 | 3.20e-05 | 1.61e-04 | 9.52e-05 | 42 |
hsa0520351 | Oral cavity | EOLP | Viral carcinogenesis | 55/1218 | 204/8465 | 1.54e-06 | 1.34e-05 | 7.92e-06 | 55 |
hsa0411051 | Oral cavity | EOLP | Cell cycle | 42/1218 | 157/8465 | 3.20e-05 | 1.61e-04 | 9.52e-05 | 42 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HDAC8 | SNV | Missense_Mutation | c.1106T>A | p.Ile369Asn | p.I369N | Q9BY41 | protein_coding | deleterious(0) | benign(0.388) | TCGA-A2-A0YF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Arimidex | SD | |
HDAC8 | SNV | Missense_Mutation | c.463N>G | p.Leu155Val | p.L155V | Q9BY41 | protein_coding | tolerated(1) | benign(0.003) | TCGA-A2-A0YK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
HDAC8 | SNV | Missense_Mutation | rs397515417 | c.932N>T | p.Thr311Met | p.T311M | Q9BY41 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-A8-A09I-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
HDAC8 | insertion | In_Frame_Ins | novel | c.365_366insAAGATATATTGTTTCCCCTACCAAGTTTGAAAAAGATTCTTT | p.Ala122_Ala123insArgTyrIleValSerProThrLysPheGluLysAspSerPhe | p.A122_A123insRYIVSPTKFEKDSF | Q9BY41 | protein_coding | TCGA-A7-A0CD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
HDAC8 | insertion | Nonsense_Mutation | novel | c.141_142insGGAGAATCGCTTGAACCCCGGAGGTGAAGG | p.Ala47_Tyr48insGlyGluSerLeuGluProArgArgTerArg | p.A47_Y48insGESLEPRR*R | Q9BY41 | protein_coding | TCGA-AO-A0JF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | ||
HDAC8 | SNV | Missense_Mutation | novel | c.926N>T | p.Ala309Val | p.A309V | Q9BY41 | protein_coding | tolerated(0.19) | benign(0.076) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HDAC8 | SNV | Missense_Mutation | c.567N>G | p.Phe189Leu | p.F189L | Q9BY41 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-BI-A0VR-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
HDAC8 | SNV | Missense_Mutation | novel | c.425A>G | p.His142Arg | p.H142R | Q9BY41 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
HDAC8 | SNV | Missense_Mutation | c.170T>G | p.Val57Gly | p.V57G | Q9BY41 | protein_coding | deleterious(0) | possibly_damaging(0.623) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HDAC8 | SNV | Missense_Mutation | novel | c.616N>A | p.Gly206Arg | p.G206R | Q9BY41 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-ZJ-AAXU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55869 | HDAC8 | DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | PMID29671355-Compound-67 | |||
55869 | HDAC8 | DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | inhibitor | 187051799 | DACINOSTAT | |
55869 | HDAC8 | DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | PMID29671355-Compound-37 | |||
55869 | HDAC8 | DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | inhibitor | PCI-24781 | ABEXINOSTAT | |
55869 | HDAC8 | DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | PHENYLBUTANOIC ACID | PHENYLBUTANOIC ACID | 24044874 | |
55869 | HDAC8 | DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | VORINOSTAT | VORINOSTAT | ||
55869 | HDAC8 | DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | inhibitor | PANOBINOSTAT | PANOBINOSTAT | |
55869 | HDAC8 | DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | PHENYLBUTYRYLHYDROXAMIC ACID | PHENYLBUTYRYLHYDROXAMIC ACID | 21874153 | |
55869 | HDAC8 | DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | PMID29671355-Compound-25 | |||
55869 | HDAC8 | DRUGGABLE GENOME, ENZYME, TRANSCRIPTION FACTOR | inhibitor | 187051793 | GIVINOSTAT |
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