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Gene: CEL |
Gene summary for CEL |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | CEL | Gene ID | 1056 |
| Gene name | carboxyl ester lipase | |
| Gene Alias | BAL | |
| Cytomap | 9q34.13 | |
| Gene Type | protein-coding | GO ID | GO:0001941 | UniProtAcc | B4DSX9 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 1056 | CEL | HTA11_99999971662_82457 | Human | Colorectum | MSS | 5.53e-05 | 1.33e-01 | 0.3859 |
| 1056 | CEL | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.86e-04 | 2.59e-01 | 0.2585 |
| 1056 | CEL | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.34e-96 | 1.89e+00 | 0.3005 |
| 1056 | CEL | CRC-1-8810 | Human | Colorectum | CRC | 5.83e-13 | 5.65e-01 | 0.6257 |
| 1056 | CEL | HTA12-15-2 | Human | Pancreas | PDAC | 2.78e-44 | -2.37e+00 | 0.2315 |
| 1056 | CEL | HTA12-23-1 | Human | Pancreas | PDAC | 5.00e-31 | -2.37e+00 | 0.3405 |
| 1056 | CEL | HTA12-25-1 | Human | Pancreas | PDAC | 1.86e-43 | -2.37e+00 | 0.313 |
| 1056 | CEL | HTA12-26-1 | Human | Pancreas | PDAC | 3.54e-52 | -2.37e+00 | 0.3728 |
| 1056 | CEL | HTA12-29-1 | Human | Pancreas | PDAC | 1.09e-119 | -2.37e+00 | 0.3722 |
| 1056 | CEL | HTA12-3-16 | Human | Pancreas | PDAC | 1.74e-10 | -2.37e+00 | 0.1553 |
| 1056 | CEL | HTA12-30-1 | Human | Pancreas | PDAC | 1.00e-11 | -2.37e+00 | 0.3671 |
| 1056 | CEL | HTA12-32-1 | Human | Pancreas | PDAC | 7.29e-14 | -1.93e+00 | 0.3624 |
| 1056 | CEL | HTA12-9-1 | Human | Pancreas | PDAC | 5.33e-67 | -2.30e+00 | 0.1532 |
| 1056 | CEL | HTA12-9-2 | Human | Pancreas | PDAC | 2.43e-26 | -5.78e-01 | 0.0835 |
| 1056 | CEL | HTA12-9-3 | Human | Pancreas | PDAC | 1.45e-36 | -2.37e+00 | 0.2045 |
| 1056 | CEL | 4347-EC | Human | Pancreas | PanIN | 4.74e-45 | -5.13e-01 | 0.0572 |
| 1056 | CEL | 4741-EC1 | Human | Pancreas | PanIN | 1.76e-02 | 1.12e-01 | 0.0223 |
| 1056 | CEL | 4741-EC2 | Human | Pancreas | PanIN | 1.33e-21 | 1.56e-01 | 0.0194 |
| 1056 | CEL | 181429 | Human | Pancreas | PDAC | 8.07e-20 | -2.37e+00 | 0.1416 |
| 1056 | CEL | 61354830 | Human | Pancreas | PDAC | 1.00e-11 | -2.37e+00 | 0.1458 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00459273 | Colorectum | FAP | positive regulation of growth | 66/2622 | 259/18723 | 6.11e-07 | 3.05e-05 | 66 |
| GO:00442704 | Colorectum | FAP | cellular nitrogen compound catabolic process | 101/2622 | 451/18723 | 7.42e-07 | 3.44e-05 | 101 |
| GO:00718264 | Colorectum | FAP | ribonucleoprotein complex subunit organization | 59/2622 | 227/18723 | 1.18e-06 | 5.26e-05 | 59 |
| GO:00346554 | Colorectum | FAP | nucleobase-containing compound catabolic process | 92/2622 | 407/18723 | 1.50e-06 | 6.49e-05 | 92 |
| GO:00226184 | Colorectum | FAP | ribonucleoprotein complex assembly | 57/2622 | 220/18723 | 1.99e-06 | 8.03e-05 | 57 |
| GO:00467004 | Colorectum | FAP | heterocycle catabolic process | 98/2622 | 445/18723 | 2.36e-06 | 9.21e-05 | 98 |
| GO:00003814 | Colorectum | FAP | regulation of alternative mRNA splicing, via spliceosome | 23/2622 | 60/18723 | 2.58e-06 | 9.88e-05 | 23 |
| GO:19033132 | Colorectum | FAP | positive regulation of mRNA metabolic process | 36/2622 | 118/18723 | 2.94e-06 | 1.09e-04 | 36 |
| GO:00486392 | Colorectum | FAP | positive regulation of developmental growth | 47/2622 | 174/18723 | 4.55e-06 | 1.52e-04 | 47 |
| GO:00194394 | Colorectum | FAP | aromatic compound catabolic process | 100/2622 | 467/18723 | 6.75e-06 | 2.08e-04 | 100 |
| GO:00486382 | Colorectum | FAP | regulation of developmental growth | 75/2622 | 330/18723 | 1.11e-05 | 3.10e-04 | 75 |
| GO:00610142 | Colorectum | FAP | positive regulation of mRNA catabolic process | 27/2622 | 87/18723 | 3.50e-05 | 7.69e-04 | 27 |
| GO:19013614 | Colorectum | FAP | organic cyclic compound catabolic process | 101/2622 | 495/18723 | 4.87e-05 | 9.93e-04 | 101 |
| GO:00611572 | Colorectum | FAP | mRNA destabilization | 25/2622 | 84/18723 | 1.43e-04 | 2.24e-03 | 25 |
| GO:00507792 | Colorectum | FAP | RNA destabilization | 25/2622 | 88/18723 | 3.19e-04 | 4.12e-03 | 25 |
| GO:00226134 | Colorectum | FAP | ribonucleoprotein complex biogenesis | 91/2622 | 463/18723 | 4.28e-04 | 5.12e-03 | 91 |
| GO:0021987 | Colorectum | FAP | cerebral cortex development | 28/2622 | 114/18723 | 1.80e-03 | 1.55e-02 | 28 |
| GO:00352641 | Colorectum | FAP | multicellular organism growth | 31/2622 | 132/18723 | 2.28e-03 | 1.84e-02 | 31 |
| GO:00171481 | Colorectum | FAP | negative regulation of translation | 50/2622 | 245/18723 | 3.57e-03 | 2.57e-02 | 50 |
| GO:00342491 | Colorectum | FAP | negative regulation of cellular amide metabolic process | 54/2622 | 273/18723 | 5.00e-03 | 3.33e-02 | 54 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa005612 | Colorectum | MSS | Glycerolipid metabolism | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
| hsa049724 | Colorectum | MSS | Pancreatic secretion | 33/1875 | 102/8465 | 1.09e-02 | 3.75e-02 | 2.30e-02 | 33 |
| hsa005613 | Colorectum | MSS | Glycerolipid metabolism | 23/1875 | 63/8465 | 6.55e-03 | 2.64e-02 | 1.62e-02 | 23 |
| hsa049725 | Colorectum | MSS | Pancreatic secretion | 33/1875 | 102/8465 | 1.09e-02 | 3.75e-02 | 2.30e-02 | 33 |
| hsa049728 | Colorectum | CRC | Pancreatic secretion | 32/1091 | 102/8465 | 7.86e-07 | 4.37e-05 | 2.96e-05 | 32 |
| hsa049729 | Colorectum | CRC | Pancreatic secretion | 32/1091 | 102/8465 | 7.86e-07 | 4.37e-05 | 2.96e-05 | 32 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| CEL | SNV | Missense_Mutation | rs755884951 | c.1709A>G | p.Glu570Gly | p.E570G | protein_coding | tolerated(0.12) | benign(0) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
| CEL | SNV | Missense_Mutation | c.1558N>T | p.Gly520Cys | p.G520C | protein_coding | tolerated(0.1) | probably_damaging(0.958) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | ||
| CEL | SNV | Missense_Mutation | rs752422506 | c.1544N>A | p.Thr515Asn | p.T515N | protein_coding | tolerated(0.16) | benign(0.203) | TCGA-E2-A1IE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
| CEL | SNV | Missense_Mutation | rs746397927 | c.994N>A | p.Asp332Asn | p.D332N | protein_coding | deleterious(0.04) | possibly_damaging(0.562) | TCGA-E9-A1RC-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
| CEL | SNV | Missense_Mutation | novel | c.2149N>A | p.Val717Met | p.V717M | protein_coding | tolerated_low_confidence(0.08) | benign(0.154) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| CEL | SNV | Missense_Mutation | rs760144206 | c.730G>A | p.Gly244Ser | p.G244S | protein_coding | deleterious(0.01) | probably_damaging(0.968) | TCGA-LP-A4AW-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| CEL | SNV | Missense_Mutation | rs201133893 | c.2171N>A | p.Gly724Glu | p.G724E | protein_coding | tolerated_low_confidence(1) | benign(0.001) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| CEL | SNV | Missense_Mutation | rs202034862 | c.2173N>A | p.Ala725Thr | p.A725T | protein_coding | deleterious_low_confidence(0.02) | benign(0.219) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| CEL | SNV | Missense_Mutation | rs202034862 | c.2173G>C | p.Ala725Pro | p.A725P | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.644) | TCGA-AA-3713-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PR | |
| CEL | SNV | Missense_Mutation | c.832N>A | p.Ala278Thr | p.A278T | protein_coding | deleterious(0) | possibly_damaging(0.89) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 1056 | CEL | CELL SURFACE, DRUGGABLE GENOME, ENZYME | Bucelipase alfa | |||
| 1056 | CEL | CELL SURFACE, DRUGGABLE GENOME, ENZYME | ACTINOMYCIN D | 2016288 | ||
| 1056 | CEL | CELL SURFACE, DRUGGABLE GENOME, ENZYME | GENISTEIN | GENISTEIN | 10600647 | |
| 1056 | CEL | CELL SURFACE, DRUGGABLE GENOME, ENZYME | RESVERATROL | RESVERATROL | 16099206 | |
| 1056 | CEL | CELL SURFACE, DRUGGABLE GENOME, ENZYME | SIMVASTATIN | SIMVASTATIN | 16955753 | |
| 1056 | CEL | CELL SURFACE, DRUGGABLE GENOME, ENZYME | GELDANAMYCIN | GELDANAMYCIN | 11104697 | |
| 1056 | CEL | CELL SURFACE, DRUGGABLE GENOME, ENZYME | BILE SALT STIMULATED LIPASE | |||
| 1056 | CEL | CELL SURFACE, DRUGGABLE GENOME, ENZYME | Taurocholic Acid |
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