Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/CCT3_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/CCT3_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/CCT3_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/CCT3_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/CCT3_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/CCT3_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/CCT3_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/CCT3_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/CCT3_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190340513 | Endometrium | EEC | protein localization to nuclear body | 8/2168 | 12/18723 | 1.03e-05 | 2.22e-04 | 8 |
GO:190481613 | Endometrium | EEC | positive regulation of protein localization to chromosome, telomeric region | 8/2168 | 12/18723 | 1.03e-05 | 2.22e-04 | 8 |
GO:190486713 | Endometrium | EEC | protein localization to Cajal body | 8/2168 | 12/18723 | 1.03e-05 | 2.22e-04 | 8 |
GO:190018213 | Endometrium | EEC | positive regulation of protein localization to nucleus | 25/2168 | 87/18723 | 1.12e-05 | 2.34e-04 | 25 |
GO:000627813 | Endometrium | EEC | RNA-dependent DNA biosynthetic process | 22/2168 | 75/18723 | 2.59e-05 | 4.56e-04 | 22 |
GO:001083314 | Endometrium | EEC | telomere maintenance via telomere lengthening | 23/2168 | 81/18723 | 3.05e-05 | 5.29e-04 | 23 |
GO:190435814 | Endometrium | EEC | positive regulation of telomere maintenance via telomere lengthening | 14/2168 | 37/18723 | 3.41e-05 | 5.78e-04 | 14 |
GO:003220613 | Endometrium | EEC | positive regulation of telomere maintenance | 17/2168 | 52/18723 | 4.62e-05 | 7.45e-04 | 17 |
GO:190481412 | Endometrium | EEC | regulation of protein localization to chromosome, telomeric region | 8/2168 | 14/18723 | 5.02e-05 | 8.06e-04 | 8 |
GO:003221213 | Endometrium | EEC | positive regulation of telomere maintenance via telomerase | 13/2168 | 34/18723 | 5.71e-05 | 8.96e-04 | 13 |
GO:003221013 | Endometrium | EEC | regulation of telomere maintenance via telomerase | 17/2168 | 53/18723 | 6.07e-05 | 9.21e-04 | 17 |
GO:190018013 | Endometrium | EEC | regulation of protein localization to nucleus | 32/2168 | 136/18723 | 6.37e-05 | 9.48e-04 | 32 |
GO:007189713 | Endometrium | EEC | DNA biosynthetic process | 39/2168 | 180/18723 | 7.68e-05 | 1.11e-03 | 39 |
GO:200057314 | Endometrium | EEC | positive regulation of DNA biosynthetic process | 19/2168 | 66/18723 | 1.19e-04 | 1.59e-03 | 19 |
GO:190435613 | Endometrium | EEC | regulation of telomere maintenance via telomere lengthening | 18/2168 | 61/18723 | 1.26e-04 | 1.66e-03 | 18 |
GO:007020012 | Endometrium | EEC | establishment of protein localization to telomere | 8/2168 | 16/18723 | 1.74e-04 | 2.15e-03 | 8 |
GO:007019812 | Endometrium | EEC | protein localization to chromosome, telomeric region | 11/2168 | 29/18723 | 2.31e-04 | 2.73e-03 | 11 |
GO:007019911 | Endometrium | EEC | establishment of protein localization to chromosome | 10/2168 | 25/18723 | 2.67e-04 | 3.04e-03 | 10 |
GO:000072313 | Endometrium | EEC | telomere maintenance | 29/2168 | 131/18723 | 4.15e-04 | 4.37e-03 | 29 |
GO:003220413 | Endometrium | EEC | regulation of telomere maintenance | 20/2168 | 80/18723 | 6.28e-04 | 6.17e-03 | 20 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CCT3 | SNV | Missense_Mutation | novel | c.1345C>A | p.Arg449Ser | p.R449S | P49368 | protein_coding | deleterious(0.04) | possibly_damaging(0.531) | TCGA-A7-A4SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
CCT3 | SNV | Missense_Mutation | rs763340746 | c.1535N>T | p.Thr512Met | p.T512M | P49368 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD |
CCT3 | SNV | Missense_Mutation | | c.773N>G | p.Ile258Ser | p.I258S | P49368 | protein_coding | deleterious(0) | possibly_damaging(0.883) | TCGA-D8-A1X9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
CCT3 | SNV | Missense_Mutation | rs746245572 | c.710N>A | p.Arg237His | p.R237H | P49368 | protein_coding | deleterious(0) | possibly_damaging(0.803) | TCGA-D8-A1XT-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
CCT3 | SNV | Missense_Mutation | | c.1447G>A | p.Glu483Lys | p.E483K | P49368 | protein_coding | tolerated(0.47) | benign(0.013) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD |
CCT3 | insertion | Nonsense_Mutation | novel | c.1227_1228insAAGACCTAACTTTATGGTTAG | p.Pro409_Gly410insLysThrTerLeuTyrGlyTer | p.P409_G410insKT*LYG* | P49368 | protein_coding | | | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCT3 | insertion | Nonsense_Mutation | novel | c.1225_1226insTAGCATAATGGA | p.Pro409delinsLeuAlaTerTrpThr | p.P409delinsLA*WT | P49368 | protein_coding | | | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CCT3 | SNV | Missense_Mutation | rs375964353 | c.688C>T | p.Arg230Trp | p.R230W | P49368 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CCT3 | SNV | Missense_Mutation | rs373870763 | c.1567G>A | p.Val523Ile | p.V523I | P49368 | protein_coding | tolerated(0.29) | possibly_damaging(0.546) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CCT3 | SNV | Missense_Mutation | novel | c.59G>T | p.Arg20Ile | p.R20I | P49368 | protein_coding | deleterious(0) | possibly_damaging(0.786) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |