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Gene: ARIH1 |
Gene summary for ARIH1 |
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Gene information | Species | Human | Gene symbol | ARIH1 | Gene ID | 25820 |
Gene name | ariadne RBR E3 ubiquitin protein ligase 1 | |
Gene Alias | ARI | |
Cytomap | 15q24.1 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | Q9Y4X5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
25820 | ARIH1 | CA_HPV_2 | Human | Cervix | CC | 2.34e-02 | 2.97e-01 | 0.0391 |
25820 | ARIH1 | CCI_1 | Human | Cervix | CC | 7.43e-03 | 1.03e+00 | 0.528 |
25820 | ARIH1 | CCI_2 | Human | Cervix | CC | 2.95e-10 | 1.60e+00 | 0.5249 |
25820 | ARIH1 | CCI_3 | Human | Cervix | CC | 1.12e-12 | 9.80e-01 | 0.516 |
25820 | ARIH1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.66e-15 | -5.69e-01 | 0.0155 |
25820 | ARIH1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.50e-02 | -4.28e-01 | -0.2196 |
25820 | ARIH1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.50e-07 | -5.95e-01 | -0.1207 |
25820 | ARIH1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 7.45e-05 | -4.99e-01 | -0.2061 |
25820 | ARIH1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.10e-03 | -4.28e-01 | -0.1462 |
25820 | ARIH1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.83e-11 | -4.86e-01 | 0.096 |
25820 | ARIH1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.76e-05 | -6.67e-01 | 0.0528 |
25820 | ARIH1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.44e-02 | -4.19e-01 | 0.0588 |
25820 | ARIH1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.57e-09 | -4.79e-01 | 0.3859 |
25820 | ARIH1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.39e-09 | -6.15e-01 | 0.2585 |
25820 | ARIH1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.74e-12 | -4.87e-01 | 0.3005 |
25820 | ARIH1 | F007 | Human | Colorectum | FAP | 1.18e-02 | -3.68e-01 | 0.1176 |
25820 | ARIH1 | A001-C-207 | Human | Colorectum | FAP | 2.00e-05 | -4.10e-01 | 0.1278 |
25820 | ARIH1 | A015-C-203 | Human | Colorectum | FAP | 5.17e-40 | -5.75e-01 | -0.1294 |
25820 | ARIH1 | A015-C-204 | Human | Colorectum | FAP | 2.32e-09 | -4.90e-01 | -0.0228 |
25820 | ARIH1 | A014-C-040 | Human | Colorectum | FAP | 2.68e-07 | -5.67e-01 | -0.1184 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004586222 | Liver | HCC | positive regulation of proteolysis | 232/7958 | 372/18723 | 5.66e-15 | 3.98e-13 | 232 |
GO:003243422 | Liver | HCC | regulation of proteasomal ubiquitin-dependent protein catabolic process | 100/7958 | 134/18723 | 3.67e-14 | 2.32e-12 | 100 |
GO:190305221 | Liver | HCC | positive regulation of proteolysis involved in cellular protein catabolic process | 96/7958 | 133/18723 | 3.47e-12 | 1.57e-10 | 96 |
GO:190180012 | Liver | HCC | positive regulation of proteasomal protein catabolic process | 84/7958 | 114/18723 | 1.28e-11 | 5.21e-10 | 84 |
GO:000020921 | Liver | HCC | protein polyubiquitination | 151/7958 | 236/18723 | 1.90e-11 | 7.59e-10 | 151 |
GO:200006022 | Liver | HCC | positive regulation of ubiquitin-dependent protein catabolic process | 76/7958 | 107/18723 | 2.06e-09 | 5.79e-08 | 76 |
GO:003243612 | Liver | HCC | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 66/7958 | 90/18723 | 2.79e-09 | 7.55e-08 | 66 |
GO:00098968 | Lung | IAC | positive regulation of catabolic process | 114/2061 | 492/18723 | 4.93e-15 | 1.25e-11 | 114 |
GO:00421768 | Lung | IAC | regulation of protein catabolic process | 97/2061 | 391/18723 | 6.32e-15 | 1.25e-11 | 97 |
GO:00313318 | Lung | IAC | positive regulation of cellular catabolic process | 98/2061 | 427/18723 | 7.79e-13 | 9.25e-10 | 98 |
GO:00457328 | Lung | IAC | positive regulation of protein catabolic process | 61/2061 | 231/18723 | 4.44e-11 | 1.39e-08 | 61 |
GO:19033628 | Lung | IAC | regulation of cellular protein catabolic process | 63/2061 | 255/18723 | 4.30e-10 | 9.45e-08 | 63 |
GO:00458628 | Lung | IAC | positive regulation of proteolysis | 80/2061 | 372/18723 | 2.62e-09 | 4.21e-07 | 80 |
GO:19030508 | Lung | IAC | regulation of proteolysis involved in cellular protein catabolic process | 52/2061 | 221/18723 | 7.90e-08 | 7.95e-06 | 52 |
GO:20000588 | Lung | IAC | regulation of ubiquitin-dependent protein catabolic process | 42/2061 | 164/18723 | 1.16e-07 | 1.07e-05 | 42 |
GO:19033648 | Lung | IAC | positive regulation of cellular protein catabolic process | 40/2061 | 155/18723 | 1.84e-07 | 1.56e-05 | 40 |
GO:00104988 | Lung | IAC | proteasomal protein catabolic process | 90/2061 | 490/18723 | 6.69e-07 | 3.89e-05 | 90 |
GO:20000608 | Lung | IAC | positive regulation of ubiquitin-dependent protein catabolic process | 30/2061 | 107/18723 | 9.37e-07 | 5.20e-05 | 30 |
GO:00431618 | Lung | IAC | proteasome-mediated ubiquitin-dependent protein catabolic process | 78/2061 | 412/18723 | 1.10e-06 | 6.02e-05 | 78 |
GO:19030526 | Lung | IAC | positive regulation of proteolysis involved in cellular protein catabolic process | 33/2061 | 133/18723 | 5.33e-06 | 2.08e-04 | 33 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ARIH1 | SNV | Missense_Mutation | rs767859277 | c.1226N>A | p.Ala409Glu | p.A409E | Q9Y4X5 | protein_coding | tolerated(0.06) | benign(0.043) | TCGA-A2-A25C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
ARIH1 | SNV | Missense_Mutation | novel | c.1552N>A | p.Leu518Met | p.L518M | Q9Y4X5 | protein_coding | deleterious(0.02) | probably_damaging(0.974) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
ARIH1 | SNV | Missense_Mutation | rs767859277 | c.1226N>A | p.Ala409Glu | p.A409E | Q9Y4X5 | protein_coding | tolerated(0.06) | benign(0.043) | TCGA-D8-A1JN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozolum | SD |
ARIH1 | SNV | Missense_Mutation | rs767859277 | c.1226N>A | p.Ala409Glu | p.A409E | Q9Y4X5 | protein_coding | tolerated(0.06) | benign(0.043) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ARIH1 | SNV | Missense_Mutation | c.1532N>T | p.Arg511Leu | p.R511L | Q9Y4X5 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-E2-A15S-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
ARIH1 | SNV | Missense_Mutation | rs767859277 | c.1226N>A | p.Ala409Glu | p.A409E | Q9Y4X5 | protein_coding | tolerated(0.06) | benign(0.043) | TCGA-E2-A1L6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
ARIH1 | SNV | Missense_Mutation | c.1532N>A | p.Arg511Gln | p.R511Q | Q9Y4X5 | protein_coding | tolerated(0.18) | benign(0.41) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ARIH1 | SNV | Missense_Mutation | c.1342C>T | p.His448Tyr | p.H448Y | Q9Y4X5 | protein_coding | tolerated(0.05) | possibly_damaging(0.759) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ARIH1 | SNV | Missense_Mutation | novel | c.906N>C | p.Gln302His | p.Q302H | Q9Y4X5 | protein_coding | tolerated(0.12) | possibly_damaging(0.814) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
ARIH1 | SNV | Missense_Mutation | novel | c.1202N>A | p.Arg401Lys | p.R401K | Q9Y4X5 | protein_coding | tolerated(0.06) | possibly_damaging(0.553) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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