Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: ANAPC5

Gene summary for ANAPC5

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

ANAPC5

Gene ID

51433

Gene nameanaphase promoting complex subunit 5
Gene AliasAPC5
Cytomap12q24.31
Gene Typeprotein-coding
GO ID

GO:0000070

UniProtAcc

Q9UJX4


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
51433ANAPC5HTA11_1938_2000001011HumanColorectumAD1.19e-023.96e-01-0.0811
51433ANAPC5HTA11_347_2000001011HumanColorectumAD5.66e-074.73e-01-0.1954
51433ANAPC5HTA11_99999965062_69753HumanColorectumMSI-H1.43e-049.39e-010.3487
51433ANAPC5A015-C-203HumanColorectumFAP1.49e-25-2.75e-01-0.1294
51433ANAPC5A015-C-204HumanColorectumFAP3.48e-03-2.82e-01-0.0228
51433ANAPC5A014-C-040HumanColorectumFAP4.74e-03-3.69e-01-0.1184
51433ANAPC5A002-C-201HumanColorectumFAP8.30e-09-2.48e-010.0324
51433ANAPC5A002-C-203HumanColorectumFAP4.73e-04-8.24e-020.2786
51433ANAPC5A001-C-119HumanColorectumFAP4.44e-06-2.81e-01-0.1557
51433ANAPC5A001-C-108HumanColorectumFAP3.85e-12-1.77e-01-0.0272
51433ANAPC5A002-C-205HumanColorectumFAP5.65e-17-3.06e-01-0.1236
51433ANAPC5A001-C-104HumanColorectumFAP7.91e-03-9.38e-020.0184
51433ANAPC5A015-C-006HumanColorectumFAP3.29e-10-2.43e-01-0.0994
51433ANAPC5A015-C-106HumanColorectumFAP1.36e-09-1.07e-01-0.0511
51433ANAPC5A002-C-114HumanColorectumFAP1.58e-13-3.04e-01-0.1561
51433ANAPC5A015-C-104HumanColorectumFAP7.03e-28-2.87e-01-0.1899
51433ANAPC5A001-C-014HumanColorectumFAP9.57e-14-1.82e-010.0135
51433ANAPC5A002-C-016HumanColorectumFAP7.66e-23-2.67e-010.0521
51433ANAPC5A015-C-002HumanColorectumFAP1.71e-09-2.31e-01-0.0763
51433ANAPC5A001-C-203HumanColorectumFAP8.09e-10-1.29e-01-0.0481
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00482854SkincSCCorganelle fission197/4864488/187231.51e-128.36e-11197
GO:009881311SkincSCCnuclear chromosome segregation126/4864281/187234.76e-122.53e-10126
GO:00002803SkincSCCnuclear division178/4864439/187231.17e-115.93e-10178
GO:190199014SkincSCCregulation of mitotic cell cycle phase transition128/4864299/187231.48e-106.56e-09128
GO:00519834SkincSCCregulation of chromosome segregation52/486491/187232.88e-101.20e-0852
GO:000020924SkincSCCprotein polyubiquitination103/4864236/187232.57e-099.09e-08103
GO:00070913SkincSCCmetaphase/anaphase transition of mitotic cell cycle37/486462/187232.13e-086.11e-0737
GO:00330453SkincSCCregulation of sister chromatid segregation41/486472/187232.48e-086.89e-0741
GO:19058183SkincSCCregulation of chromosome separation41/486472/187232.48e-086.89e-0741
GO:00300713SkincSCCregulation of mitotic metaphase/anaphase transition36/486460/187232.71e-087.41e-0736
GO:00109653SkincSCCregulation of mitotic sister chromatid separation38/486465/187233.03e-088.18e-0738
GO:190198714SkincSCCregulation of cell cycle phase transition150/4864390/187233.21e-088.61e-07150
GO:00070884SkincSCCregulation of mitotic nuclear division55/4864110/187235.62e-081.44e-0655
GO:00513063SkincSCCmitotic sister chromatid separation38/486467/187239.27e-082.22e-0638
GO:00447843SkincSCCmetaphase/anaphase transition of cell cycle37/486465/187231.20e-072.79e-0637
GO:19020993SkincSCCregulation of metaphase/anaphase transition of cell cycle36/486463/187231.55e-073.51e-0636
GO:00517832SkincSCCregulation of nuclear division64/4864139/187232.49e-075.25e-0664
GO:004578717SkincSCCpositive regulation of cell cycle120/4864313/187238.95e-071.64e-05120
GO:004593118SkincSCCpositive regulation of mitotic cell cycle56/4864121/187231.11e-061.96e-0556
GO:009006815SkincSCCpositive regulation of cell cycle process92/4864236/187237.33e-061.01e-0492
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04120ColorectumADUbiquitin mediated proteolysis58/2092142/84651.46e-051.53e-049.76e-0558
hsa05166ColorectumADHuman T-cell leukemia virus 1 infection72/2092222/84655.24e-032.44e-021.55e-0272
hsa041201ColorectumADUbiquitin mediated proteolysis58/2092142/84651.46e-051.53e-049.76e-0558
hsa051661ColorectumADHuman T-cell leukemia virus 1 infection72/2092222/84655.24e-032.44e-021.55e-0272
hsa041206ColorectumFAPUbiquitin mediated proteolysis51/1404142/84651.55e-085.84e-073.55e-0751
hsa04110ColorectumFAPCell cycle37/1404157/84651.44e-024.77e-022.90e-0237
hsa041207ColorectumFAPUbiquitin mediated proteolysis51/1404142/84651.55e-085.84e-073.55e-0751
hsa041101ColorectumFAPCell cycle37/1404157/84651.44e-024.77e-022.90e-0237
hsa041208ColorectumCRCUbiquitin mediated proteolysis42/1091142/84659.98e-086.67e-064.52e-0642
hsa041209ColorectumCRCUbiquitin mediated proteolysis42/1091142/84659.98e-086.67e-064.52e-0642
hsa0412026EsophagusHGINUbiquitin mediated proteolysis49/1383142/84657.78e-081.33e-061.06e-0649
hsa0516639EsophagusHGINHuman T-cell leukemia virus 1 infection51/1383222/84655.84e-034.05e-023.22e-0251
hsa041109EsophagusHGINCell cycle38/1383157/84656.70e-034.37e-023.47e-0238
hsa0465726EsophagusHGINIL-17 signaling pathway25/138394/84657.52e-034.63e-023.68e-0225
hsa04120111EsophagusHGINUbiquitin mediated proteolysis49/1383142/84657.78e-081.33e-061.06e-0649
hsa05166114EsophagusHGINHuman T-cell leukemia virus 1 infection51/1383222/84655.84e-034.05e-023.22e-0251
hsa0411016EsophagusHGINCell cycle38/1383157/84656.70e-034.37e-023.47e-0238
hsa04657113EsophagusHGINIL-17 signaling pathway25/138394/84657.52e-034.63e-023.68e-0225
hsa0412027EsophagusESCCUbiquitin mediated proteolysis122/4205142/84656.53e-207.29e-183.74e-18122
hsa0411023EsophagusESCCCell cycle126/4205157/84651.34e-155.60e-142.87e-14126
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
ANAPC5SNVMissense_Mutationnovelc.351T>Gp.Asp117Glup.D117EQ9UJX4protein_codingtolerated(0.26)benign(0.01)TCGA-A2-A0CL-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycytoxanSD
ANAPC5SNVMissense_Mutationrs778284423c.1984N>Tp.Arg662Cysp.R662CQ9UJX4protein_codingtolerated(0.19)benign(0.003)TCGA-AR-A1AI-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanPD
ANAPC5SNVMissense_Mutationc.677N>Tp.Asp226Valp.D226VQ9UJX4protein_codingdeleterious(0)probably_damaging(0.998)TCGA-BH-A0DL-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanCR
ANAPC5SNVMissense_Mutationc.271A>Gp.Asn91Aspp.N91DQ9UJX4protein_codingtolerated(0.57)benign(0.026)TCGA-D8-A1XQ-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
ANAPC5SNVMissense_Mutationrs747383939c.2164N>Gp.His722Aspp.H722DQ9UJX4protein_codingdeleterious(0.04)benign(0.015)TCGA-UL-AAZ6-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapyherceptinSD
ANAPC5SNVMissense_Mutationrs552135290c.1534C>Ap.Gln512Lysp.Q512KQ9UJX4protein_codingtolerated(0.32)benign(0.024)TCGA-DG-A2KJ-01Cervixcervical & endocervical cancerFemale<65III/IVChemotherapycisplatinSD
ANAPC5SNVMissense_Mutationnovelc.1765N>Cp.Glu589Glnp.E589QQ9UJX4protein_codingtolerated(0.24)benign(0.056)TCGA-Q1-A73O-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ANAPC5SNVMissense_Mutationc.1553N>Cp.Arg518Thrp.R518TQ9UJX4protein_codingdeleterious(0.01)benign(0.162)TCGA-Q1-A73O-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ANAPC5SNVMissense_Mutationnovelc.595N>Cp.Glu199Glnp.E199QQ9UJX4protein_codingtolerated(0.06)benign(0.196)TCGA-VS-A958-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
ANAPC5SNVMissense_Mutationc.770G>Ap.Ser257Asnp.S257NQ9UJX4protein_codingtolerated(0.12)benign(0.103)TCGA-AA-3672-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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