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Gene: SFRP1 |
Gene summary for SFRP1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | SFRP1 | Gene ID | 6422 |
Gene name | secreted frizzled related protein 1 | |
Gene Alias | FRP | |
Cytomap | 8p11.21 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q8N474 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6422 | SFRP1 | GSM4909281 | Human | Breast | IDC | 3.65e-14 | -5.99e-01 | 0.21 |
6422 | SFRP1 | GSM4909282 | Human | Breast | IDC | 3.92e-06 | 3.22e-01 | -0.0288 |
6422 | SFRP1 | GSM4909285 | Human | Breast | IDC | 1.08e-22 | -6.60e-01 | 0.21 |
6422 | SFRP1 | GSM4909286 | Human | Breast | IDC | 4.48e-10 | -2.24e-01 | 0.1081 |
6422 | SFRP1 | GSM4909290 | Human | Breast | IDC | 5.68e-41 | -1.06e+00 | 0.2096 |
6422 | SFRP1 | GSM4909291 | Human | Breast | IDC | 2.53e-34 | -1.06e+00 | 0.1753 |
6422 | SFRP1 | GSM4909292 | Human | Breast | IDC | 4.95e-06 | -1.03e+00 | 0.1236 |
6422 | SFRP1 | GSM4909293 | Human | Breast | IDC | 1.98e-30 | -7.28e-01 | 0.1581 |
6422 | SFRP1 | GSM4909294 | Human | Breast | IDC | 3.65e-51 | -9.71e-01 | 0.2022 |
6422 | SFRP1 | GSM4909296 | Human | Breast | IDC | 1.65e-49 | -1.03e+00 | 0.1524 |
6422 | SFRP1 | GSM4909297 | Human | Breast | IDC | 9.17e-45 | -9.94e-01 | 0.1517 |
6422 | SFRP1 | GSM4909298 | Human | Breast | IDC | 9.89e-35 | -8.24e-01 | 0.1551 |
6422 | SFRP1 | GSM4909299 | Human | Breast | IDC | 1.75e-08 | 4.47e-01 | 0.035 |
6422 | SFRP1 | GSM4909301 | Human | Breast | IDC | 7.38e-56 | -1.05e+00 | 0.1577 |
6422 | SFRP1 | GSM4909302 | Human | Breast | IDC | 8.32e-40 | -9.56e-01 | 0.1545 |
6422 | SFRP1 | GSM4909304 | Human | Breast | IDC | 3.77e-60 | -1.06e+00 | 0.1636 |
6422 | SFRP1 | GSM4909306 | Human | Breast | IDC | 2.55e-24 | -6.21e-01 | 0.1564 |
6422 | SFRP1 | GSM4909307 | Human | Breast | IDC | 1.33e-20 | -6.60e-01 | 0.1569 |
6422 | SFRP1 | GSM4909308 | Human | Breast | IDC | 1.95e-46 | -1.06e+00 | 0.158 |
6422 | SFRP1 | GSM4909311 | Human | Breast | IDC | 7.18e-39 | -8.75e-01 | 0.1534 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007030226 | Thyroid | ATC | regulation of stress-activated protein kinase signaling cascade | 89/6293 | 195/18723 | 3.05e-04 | 1.93e-03 | 89 |
GO:000182321 | Thyroid | ATC | mesonephros development | 49/6293 | 96/18723 | 3.08e-04 | 1.94e-03 | 49 |
GO:005149616 | Thyroid | ATC | positive regulation of stress fiber assembly | 30/6293 | 52/18723 | 3.08e-04 | 1.94e-03 | 30 |
GO:004666112 | Thyroid | ATC | male sex differentiation | 77/6293 | 165/18723 | 3.27e-04 | 2.04e-03 | 77 |
GO:007135627 | Thyroid | ATC | cellular response to tumor necrosis factor | 102/6293 | 229/18723 | 3.52e-04 | 2.18e-03 | 102 |
GO:003287226 | Thyroid | ATC | regulation of stress-activated MAPK cascade | 87/6293 | 192/18723 | 4.72e-04 | 2.77e-03 | 87 |
GO:004340926 | Thyroid | ATC | negative regulation of MAPK cascade | 82/6293 | 180/18723 | 5.51e-04 | 3.19e-03 | 82 |
GO:003314414 | Thyroid | ATC | negative regulation of intracellular steroid hormone receptor signaling pathway | 23/6293 | 38/18723 | 6.05e-04 | 3.44e-03 | 23 |
GO:009010111 | Thyroid | ATC | negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 62/6293 | 131/18723 | 7.59e-04 | 4.20e-03 | 62 |
GO:005073211 | Thyroid | ATC | negative regulation of peptidyl-tyrosine phosphorylation | 32/6293 | 59/18723 | 8.74e-04 | 4.72e-03 | 32 |
GO:001821211 | Thyroid | ATC | peptidyl-tyrosine modification | 156/6293 | 378/18723 | 1.01e-03 | 5.36e-03 | 156 |
GO:000758418 | Thyroid | ATC | response to nutrient | 78/6293 | 174/18723 | 1.31e-03 | 6.85e-03 | 78 |
GO:001016511 | Thyroid | ATC | response to X-ray | 20/6293 | 33/18723 | 1.33e-03 | 6.96e-03 | 20 |
GO:004001316 | Thyroid | ATC | negative regulation of locomotion | 160/6293 | 391/18723 | 1.36e-03 | 7.07e-03 | 160 |
GO:190495013 | Thyroid | ATC | negative regulation of establishment of protein localization | 61/6293 | 131/18723 | 1.38e-03 | 7.16e-03 | 61 |
GO:000840613 | Thyroid | ATC | gonad development | 96/6293 | 221/18723 | 1.40e-03 | 7.25e-03 | 96 |
GO:000725424 | Thyroid | ATC | JNK cascade | 75/6293 | 167/18723 | 1.51e-03 | 7.68e-03 | 75 |
GO:00487715 | Thyroid | ATC | tissue remodeling | 78/6293 | 175/18723 | 1.60e-03 | 8.04e-03 | 78 |
GO:003033616 | Thyroid | ATC | negative regulation of cell migration | 142/6293 | 344/18723 | 1.64e-03 | 8.22e-03 | 142 |
GO:005122413 | Thyroid | ATC | negative regulation of protein transport | 59/6293 | 127/18723 | 1.75e-03 | 8.71e-03 | 59 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0431010 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431013 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431022 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
hsa0431032 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
hsa0431016 | Oral cavity | EOLP | Wnt signaling pathway | 37/1218 | 171/8465 | 6.23e-03 | 1.83e-02 | 1.08e-02 | 37 |
hsa0431017 | Oral cavity | EOLP | Wnt signaling pathway | 37/1218 | 171/8465 | 6.23e-03 | 1.83e-02 | 1.08e-02 | 37 |
hsa0431014 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
hsa0431015 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
hsa0431023 | Prostate | Tumor | Wnt signaling pathway | 50/1791 | 171/8465 | 7.32e-03 | 2.37e-02 | 1.47e-02 | 50 |
hsa0431033 | Prostate | Tumor | Wnt signaling pathway | 50/1791 | 171/8465 | 7.32e-03 | 2.37e-02 | 1.47e-02 | 50 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SFRP1 | SNV | Missense_Mutation | rs765603358 | c.934G>A | p.Val312Met | p.V312M | Q8N474 | protein_coding | deleterious(0.02) | possibly_damaging(0.721) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
SFRP1 | SNV | Missense_Mutation | c.262G>A | p.Ala88Thr | p.A88T | Q8N474 | protein_coding | tolerated(0.17) | benign(0.062) | TCGA-AR-A0TT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
SFRP1 | SNV | Missense_Mutation | novel | c.153C>G | p.Phe51Leu | p.F51L | Q8N474 | protein_coding | tolerated(0.31) | benign(0.041) | TCGA-VS-A94X-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
SFRP1 | SNV | Missense_Mutation | novel | c.97G>A | p.Glu33Lys | p.E33K | Q8N474 | protein_coding | deleterious(0.01) | probably_damaging(0.922) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SFRP1 | SNV | Missense_Mutation | c.400G>A | p.Glu134Lys | p.E134K | Q8N474 | protein_coding | deleterious(0.01) | probably_damaging(0.934) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SFRP1 | SNV | Missense_Mutation | rs761465184 | c.845N>T | p.Thr282Met | p.T282M | Q8N474 | protein_coding | tolerated(0.19) | benign(0.354) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
SFRP1 | SNV | Missense_Mutation | c.383C>T | p.Pro128Leu | p.P128L | Q8N474 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR | |
SFRP1 | SNV | Missense_Mutation | c.103N>A | p.Asp35Asn | p.D35N | Q8N474 | protein_coding | deleterious(0) | possibly_damaging(0.856) | TCGA-EI-6506-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SFRP1 | SNV | Missense_Mutation | novel | c.457N>A | p.Glu153Lys | p.E153K | Q8N474 | protein_coding | tolerated(0.05) | benign(0.338) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SFRP1 | SNV | Missense_Mutation | novel | c.629G>T | p.Arg210Met | p.R210M | Q8N474 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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