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Gene: ID1 |
Gene summary for ID1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | ID1 | Gene ID | 3397 |
Gene name | inhibitor of DNA binding 1, HLH protein | |
Gene Alias | ID | |
Cytomap | 20q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P41134 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3397 | ID1 | CA_HPV_1 | Human | Cervix | CC | 7.97e-12 | -3.48e-01 | 0.0264 |
3397 | ID1 | Tumor | Human | Cervix | CC | 1.21e-76 | 1.23e+00 | 0.1241 |
3397 | ID1 | sample1 | Human | Cervix | CC | 1.90e-04 | 5.41e-01 | 0.0959 |
3397 | ID1 | sample3 | Human | Cervix | CC | 5.41e-99 | 1.28e+00 | 0.1387 |
3397 | ID1 | H2 | Human | Cervix | HSIL_HPV | 8.78e-08 | 4.73e-01 | 0.0632 |
3397 | ID1 | L1 | Human | Cervix | CC | 1.70e-10 | 5.05e-01 | 0.0802 |
3397 | ID1 | T1 | Human | Cervix | CC | 3.61e-12 | 6.09e-01 | 0.0918 |
3397 | ID1 | T2 | Human | Cervix | CC | 7.60e-04 | 6.39e-01 | 0.0709 |
3397 | ID1 | T3 | Human | Cervix | CC | 6.95e-95 | 1.28e+00 | 0.1389 |
3397 | ID1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.07e-17 | 5.75e-01 | 0.0155 |
3397 | ID1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.19e-24 | 1.02e+00 | -0.1808 |
3397 | ID1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.83e-11 | 9.25e-01 | 0.0216 |
3397 | ID1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.23e-34 | 1.62e+00 | -0.0811 |
3397 | ID1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.31e-17 | 8.67e-01 | -0.1088 |
3397 | ID1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.33e-27 | 9.99e-01 | -0.1954 |
3397 | ID1 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.45e-08 | 1.35e+00 | -0.2602 |
3397 | ID1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 7.36e-06 | 1.12e+00 | -0.2196 |
3397 | ID1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.22e-33 | 1.41e+00 | -0.1207 |
3397 | ID1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.39e-14 | 9.42e-01 | -0.1526 |
3397 | ID1 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.52e-54 | 1.61e+00 | -0.1464 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00901999 | Skin | cSCC | regulation of release of cytochrome c from mitochondria | 25/4864 | 48/18723 | 9.94e-05 | 9.22e-04 | 25 |
GO:1901653110 | Skin | cSCC | cellular response to peptide | 124/4864 | 359/18723 | 1.75e-04 | 1.49e-03 | 124 |
GO:000975518 | Skin | cSCC | hormone-mediated signaling pathway | 72/4864 | 190/18723 | 1.92e-04 | 1.61e-03 | 72 |
GO:199009019 | Skin | cSCC | cellular response to nerve growth factor stimulus | 26/4864 | 53/18723 | 2.58e-04 | 2.10e-03 | 26 |
GO:003149812 | Skin | cSCC | chromatin disassembly | 13/4864 | 20/18723 | 2.77e-04 | 2.22e-03 | 13 |
GO:00718241 | Skin | cSCC | protein-DNA complex subunit organization | 87/4864 | 241/18723 | 3.09e-04 | 2.47e-03 | 87 |
GO:00305208 | Skin | cSCC | intracellular estrogen receptor signaling pathway | 26/4864 | 54/18723 | 3.76e-04 | 2.95e-03 | 26 |
GO:190198313 | Skin | cSCC | regulation of protein acetylation | 34/4864 | 77/18723 | 4.10e-04 | 3.18e-03 | 34 |
GO:001082317 | Skin | cSCC | negative regulation of mitochondrion organization | 24/4864 | 49/18723 | 4.54e-04 | 3.47e-03 | 24 |
GO:00434578 | Skin | cSCC | regulation of cellular respiration | 24/4864 | 49/18723 | 4.54e-04 | 3.47e-03 | 24 |
GO:200075613 | Skin | cSCC | regulation of peptidyl-lysine acetylation | 29/4864 | 63/18723 | 4.61e-04 | 3.50e-03 | 29 |
GO:004292111 | Skin | cSCC | glucocorticoid receptor signaling pathway | 10/4864 | 14/18723 | 4.77e-04 | 3.60e-03 | 10 |
GO:005101729 | Skin | cSCC | actin filament bundle assembly | 60/4864 | 157/18723 | 4.86e-04 | 3.66e-03 | 60 |
GO:005067324 | Skin | cSCC | epithelial cell proliferation | 144/4864 | 437/18723 | 6.07e-04 | 4.38e-03 | 144 |
GO:004346720 | Skin | cSCC | regulation of generation of precursor metabolites and energy | 51/4864 | 130/18723 | 6.18e-04 | 4.46e-03 | 51 |
GO:199008918 | Skin | cSCC | response to nerve growth factor | 26/4864 | 56/18723 | 7.59e-04 | 5.27e-03 | 26 |
GO:006157229 | Skin | cSCC | actin filament bundle organization | 60/4864 | 161/18723 | 1.02e-03 | 6.86e-03 | 60 |
GO:00319583 | Skin | cSCC | corticosteroid receptor signaling pathway | 10/4864 | 15/18723 | 1.10e-03 | 7.24e-03 | 10 |
GO:190370626 | Skin | cSCC | regulation of hemopoiesis | 120/4864 | 367/18723 | 2.23e-03 | 1.32e-02 | 120 |
GO:00350654 | Skin | cSCC | regulation of histone acetylation | 24/4864 | 54/18723 | 2.49e-03 | 1.42e-02 | 24 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa043908 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa0401513 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0439013 | Cervix | CC | Hippo signaling pathway | 40/1267 | 157/8465 | 3.64e-04 | 1.82e-03 | 1.07e-03 | 40 |
hsa04015 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa040151 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa040152 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa04350 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa040153 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa043501 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa040154 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa04390 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa040155 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa043901 | Colorectum | MSS | Hippo signaling pathway | 48/1875 | 157/8465 | 8.32e-03 | 3.10e-02 | 1.90e-02 | 48 |
hsa040156 | Colorectum | FAP | Rap1 signaling pathway | 53/1404 | 210/8465 | 7.93e-04 | 5.14e-03 | 3.13e-03 | 53 |
hsa043902 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa040157 | Colorectum | FAP | Rap1 signaling pathway | 53/1404 | 210/8465 | 7.93e-04 | 5.14e-03 | 3.13e-03 | 53 |
hsa043903 | Colorectum | FAP | Hippo signaling pathway | 41/1404 | 157/8465 | 1.49e-03 | 7.91e-03 | 4.81e-03 | 41 |
hsa0401514 | Endometrium | AEH | Rap1 signaling pathway | 49/1197 | 210/8465 | 2.03e-04 | 1.78e-03 | 1.30e-03 | 49 |
hsa043909 | Endometrium | AEH | Hippo signaling pathway | 38/1197 | 157/8465 | 4.79e-04 | 3.38e-03 | 2.47e-03 | 38 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
ID1 | KER | Skin | ADJ | ID2,ID3,JUNB, etc. | 1.65e-01 |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ID1 | SNV | Missense_Mutation | novel | c.283N>T | p.Leu95Phe | p.L95F | P41134 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ID1 | SNV | Missense_Mutation | novel | c.69N>C | p.Lys23Asn | p.K23N | P41134 | protein_coding | deleterious(0.01) | benign(0.444) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
ID1 | SNV | Missense_Mutation | rs756315343 | c.350C>T | p.Thr117Ile | p.T117I | P41134 | protein_coding | tolerated(0.21) | benign(0.03) | TCGA-A5-A0GH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ID1 | SNV | Missense_Mutation | c.391A>G | p.Thr131Ala | p.T131A | P41134 | protein_coding | tolerated(0.46) | benign(0.094) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ID1 | SNV | Missense_Mutation | c.313N>T | p.Leu105Phe | p.L105F | P41134 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A17H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
ID1 | SNV | Missense_Mutation | novel | c.346N>A | p.Gly116Arg | p.G116R | P41134 | protein_coding | tolerated(0.42) | benign(0.007) | TCGA-SL-A6J9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ID1 | SNV | Missense_Mutation | novel | c.463N>A | p.Arg155Ser | p.R155S | P41134 | protein_coding | deleterious(0) | benign(0.44) | TCGA-DD-AADO-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ID1 | SNV | Missense_Mutation | c.64G>T | p.Gly22Cys | p.G22C | P41134 | protein_coding | tolerated(0.17) | probably_damaging(0.976) | TCGA-69-7978-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ID1 | SNV | Missense_Mutation | rs758048335 | c.103N>G | p.Leu35Val | p.L35V | P41134 | protein_coding | tolerated(0.09) | probably_damaging(0.991) | TCGA-34-8454-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
ID1 | SNV | Missense_Mutation | c.338N>T | p.Ser113Phe | p.S113F | P41134 | protein_coding | deleterious(0) | benign(0.251) | TCGA-BR-7959-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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