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Gene: WDR1 |
Gene summary for WDR1 |
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Gene information | Species | Human | Gene symbol | WDR1 | Gene ID | 9948 |
Gene name | WD repeat domain 1 | |
Gene Alias | AIP1 | |
Cytomap | 4p16.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O75083 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9948 | WDR1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.50e-12 | 7.03e-01 | -0.1808 |
9948 | WDR1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 5.16e-12 | 7.43e-01 | -0.0811 |
9948 | WDR1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.16e-09 | 5.47e-01 | -0.1088 |
9948 | WDR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.84e-26 | 7.52e-01 | -0.1954 |
9948 | WDR1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.94e-10 | 1.37e+00 | -0.2602 |
9948 | WDR1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.18e-05 | 8.15e-01 | -0.2196 |
9948 | WDR1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.25e-02 | 4.03e-01 | -0.1207 |
9948 | WDR1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.23e-05 | 6.57e-01 | -0.1526 |
9948 | WDR1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.50e-17 | 6.21e-01 | -0.1464 |
9948 | WDR1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.94e-05 | 2.52e-01 | -0.1001 |
9948 | WDR1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.98e-15 | 8.14e-01 | -0.059 |
9948 | WDR1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.65e-09 | 1.11e+00 | -0.1706 |
9948 | WDR1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.39e-06 | 7.70e-01 | -0.2061 |
9948 | WDR1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.04e-02 | 3.81e-01 | -0.0179 |
9948 | WDR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 9.23e-09 | 4.61e-01 | 0.096 |
9948 | WDR1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.16e-02 | 4.75e-01 | -0.0177 |
9948 | WDR1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.82e-05 | 8.33e-01 | 0.0171 |
9948 | WDR1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.66e-10 | 4.19e-01 | 0.0674 |
9948 | WDR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.51e-15 | 4.73e-01 | 0.294 |
9948 | WDR1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.57e-10 | 5.91e-01 | 0.281 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00080647 | Liver | Cirrhotic | regulation of actin polymerization or depolymerization | 74/4634 | 188/18723 | 6.26e-06 | 9.92e-05 | 74 |
GO:00308327 | Liver | Cirrhotic | regulation of actin filament length | 74/4634 | 189/18723 | 7.83e-06 | 1.18e-04 | 74 |
GO:000716312 | Liver | Cirrhotic | establishment or maintenance of cell polarity | 82/4634 | 218/18723 | 1.55e-05 | 2.11e-04 | 82 |
GO:00308656 | Liver | Cirrhotic | cortical cytoskeleton organization | 30/4634 | 61/18723 | 3.16e-05 | 3.93e-04 | 30 |
GO:003103212 | Liver | Cirrhotic | actomyosin structure organization | 74/4634 | 196/18723 | 3.39e-05 | 4.17e-04 | 74 |
GO:00329846 | Liver | Cirrhotic | protein-containing complex disassembly | 82/4634 | 224/18723 | 4.78e-05 | 5.54e-04 | 82 |
GO:004521612 | Liver | Cirrhotic | cell-cell junction organization | 70/4634 | 200/18723 | 7.23e-04 | 5.36e-03 | 70 |
GO:0042063 | Liver | Cirrhotic | gliogenesis | 98/4634 | 301/18723 | 1.28e-03 | 8.60e-03 | 98 |
GO:005105211 | Liver | Cirrhotic | regulation of DNA metabolic process | 114/4634 | 359/18723 | 1.48e-03 | 9.85e-03 | 114 |
GO:0010001 | Liver | Cirrhotic | glial cell differentiation | 75/4634 | 225/18723 | 2.24e-03 | 1.36e-02 | 75 |
GO:00300426 | Liver | Cirrhotic | actin filament depolymerization | 24/4634 | 59/18723 | 5.06e-03 | 2.62e-02 | 24 |
GO:00070437 | Liver | Cirrhotic | cell-cell junction assembly | 50/4634 | 146/18723 | 6.23e-03 | 3.09e-02 | 50 |
GO:00308346 | Liver | Cirrhotic | regulation of actin filament depolymerization | 22/4634 | 54/18723 | 6.96e-03 | 3.39e-02 | 22 |
GO:00432976 | Liver | Cirrhotic | apical junction assembly | 29/4634 | 78/18723 | 9.80e-03 | 4.41e-02 | 29 |
GO:0048709 | Liver | Cirrhotic | oligodendrocyte differentiation | 34/4634 | 95/18723 | 1.06e-02 | 4.66e-02 | 34 |
GO:002261322 | Liver | HCC | ribonucleoprotein complex biogenesis | 355/7958 | 463/18723 | 7.76e-52 | 4.92e-48 | 355 |
GO:004225422 | Liver | HCC | ribosome biogenesis | 246/7958 | 299/18723 | 4.99e-46 | 1.58e-42 | 246 |
GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
GO:001607212 | Liver | HCC | rRNA metabolic process | 193/7958 | 236/18723 | 1.26e-35 | 1.14e-32 | 193 |
GO:000636421 | Liver | HCC | rRNA processing | 185/7958 | 225/18723 | 8.14e-35 | 6.45e-32 | 185 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR1 | SNV | Missense_Mutation | novel | c.1043N>G | p.Tyr348Cys | p.Y348C | O75083 | protein_coding | tolerated(0.14) | possibly_damaging(0.807) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
WDR1 | SNV | Missense_Mutation | novel | c.1041N>G | p.Asn347Lys | p.N347K | O75083 | protein_coding | tolerated(0.3) | possibly_damaging(0.739) | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
WDR1 | SNV | Missense_Mutation | c.1606N>C | p.Val536Leu | p.V536L | O75083 | protein_coding | tolerated(0.11) | benign(0.02) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
WDR1 | deletion | Frame_Shift_Del | novel | c.748delN | p.Leu250PhefsTer16 | p.L250Ffs*16 | O75083 | protein_coding | TCGA-GI-A2C9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | SD | |||
WDR1 | SNV | Missense_Mutation | novel | c.532C>T | p.Pro178Ser | p.P178S | O75083 | protein_coding | deleterious(0) | benign(0.03) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR1 | SNV | Missense_Mutation | rs545497657 | c.700G>A | p.Asp234Asn | p.D234N | O75083 | protein_coding | tolerated(0.49) | benign(0.011) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
WDR1 | SNV | Missense_Mutation | rs868174972 | c.200N>T | p.Ala67Val | p.A67V | O75083 | protein_coding | deleterious(0.01) | benign(0.343) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
WDR1 | SNV | Missense_Mutation | novel | c.638N>C | p.Ile213Thr | p.I213T | O75083 | protein_coding | deleterious(0.01) | possibly_damaging(0.493) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
WDR1 | SNV | Missense_Mutation | c.1319N>A | p.Ser440Asn | p.S440N | O75083 | protein_coding | tolerated(0.11) | benign(0) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
WDR1 | SNV | Missense_Mutation | rs370326840 | c.1222G>A | p.Val408Ile | p.V408I | O75083 | protein_coding | tolerated(0.4) | benign(0) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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