![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: USP14 |
Gene summary for USP14 |
![]() |
Gene information | Species | Human | Gene symbol | USP14 | Gene ID | 9097 |
Gene name | ubiquitin specific peptidase 14 | |
Gene Alias | TGT | |
Cytomap | 18p11.32 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | P54578 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9097 | USP14 | GSM4909287 | Human | Breast | IDC | 2.36e-07 | 4.04e-01 | 0.2057 |
9097 | USP14 | GSM4909291 | Human | Breast | IDC | 3.60e-05 | 4.08e-01 | 0.1753 |
9097 | USP14 | GSM4909293 | Human | Breast | IDC | 2.13e-22 | 5.00e-01 | 0.1581 |
9097 | USP14 | GSM4909296 | Human | Breast | IDC | 1.86e-02 | -1.04e-01 | 0.1524 |
9097 | USP14 | GSM4909311 | Human | Breast | IDC | 1.12e-06 | -1.85e-01 | 0.1534 |
9097 | USP14 | GSM4909312 | Human | Breast | IDC | 1.06e-02 | -1.62e-01 | 0.1552 |
9097 | USP14 | GSM4909319 | Human | Breast | IDC | 4.32e-10 | -1.33e-01 | 0.1563 |
9097 | USP14 | brca2 | Human | Breast | Precancer | 5.30e-05 | 1.68e-01 | -0.024 |
9097 | USP14 | P1 | Human | Breast | IDC | 1.71e-02 | 1.58e-02 | 0.1527 |
9097 | USP14 | DCIS2 | Human | Breast | DCIS | 4.49e-59 | 2.92e-01 | 0.0085 |
9097 | USP14 | LZE2T | Human | Esophagus | ESCC | 5.73e-14 | 2.38e+00 | 0.082 |
9097 | USP14 | LZE3D | Human | Esophagus | HGIN | 2.75e-02 | 4.34e-01 | 0.0668 |
9097 | USP14 | LZE4T | Human | Esophagus | ESCC | 2.91e-10 | 4.23e-01 | 0.0811 |
9097 | USP14 | LZE7T | Human | Esophagus | ESCC | 1.67e-05 | 6.25e-01 | 0.0667 |
9097 | USP14 | LZE8T | Human | Esophagus | ESCC | 5.28e-10 | 3.19e-02 | 0.067 |
9097 | USP14 | LZE20T | Human | Esophagus | ESCC | 7.72e-08 | 1.37e-01 | 0.0662 |
9097 | USP14 | LZE24T | Human | Esophagus | ESCC | 2.72e-14 | 4.40e-01 | 0.0596 |
9097 | USP14 | LZE21T | Human | Esophagus | ESCC | 8.77e-07 | 3.78e-01 | 0.0655 |
9097 | USP14 | LZE6T | Human | Esophagus | ESCC | 1.05e-10 | 5.51e-01 | 0.0845 |
9097 | USP14 | P1T-E | Human | Esophagus | ESCC | 3.46e-09 | 4.80e-01 | 0.0875 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190305019 | Prostate | Tumor | regulation of proteolysis involved in cellular protein catabolic process | 83/3246 | 221/18723 | 5.12e-13 | 5.49e-11 | 83 |
GO:004316119 | Prostate | Tumor | proteasome-mediated ubiquitin-dependent protein catabolic process | 130/3246 | 412/18723 | 7.97e-13 | 8.00e-11 | 130 |
GO:200005819 | Prostate | Tumor | regulation of ubiquitin-dependent protein catabolic process | 66/3246 | 164/18723 | 3.30e-12 | 2.78e-10 | 66 |
GO:006113619 | Prostate | Tumor | regulation of proteasomal protein catabolic process | 71/3246 | 187/18723 | 1.34e-11 | 1.00e-09 | 71 |
GO:005254719 | Prostate | Tumor | regulation of peptidase activity | 137/3246 | 461/18723 | 2.48e-11 | 1.71e-09 | 137 |
GO:003243419 | Prostate | Tumor | regulation of proteasomal ubiquitin-dependent protein catabolic process | 55/3246 | 134/18723 | 8.40e-11 | 5.27e-09 | 55 |
GO:005254819 | Prostate | Tumor | regulation of endopeptidase activity | 126/3246 | 432/18723 | 5.86e-10 | 3.01e-08 | 126 |
GO:004217718 | Prostate | Tumor | negative regulation of protein catabolic process | 49/3246 | 121/18723 | 1.53e-09 | 7.19e-08 | 49 |
GO:000989518 | Prostate | Tumor | negative regulation of catabolic process | 96/3246 | 320/18723 | 1.40e-08 | 5.07e-07 | 96 |
GO:004586119 | Prostate | Tumor | negative regulation of proteolysis | 102/3246 | 351/18723 | 3.09e-08 | 9.94e-07 | 102 |
GO:003133019 | Prostate | Tumor | negative regulation of cellular catabolic process | 81/3246 | 262/18723 | 4.42e-08 | 1.37e-06 | 81 |
GO:190589719 | Prostate | Tumor | regulation of response to endoplasmic reticulum stress | 35/3246 | 82/18723 | 6.76e-08 | 1.95e-06 | 35 |
GO:200005918 | Prostate | Tumor | negative regulation of ubiquitin-dependent protein catabolic process | 24/3246 | 48/18723 | 2.17e-07 | 5.26e-06 | 24 |
GO:190336316 | Prostate | Tumor | negative regulation of cellular protein catabolic process | 32/3246 | 75/18723 | 2.47e-07 | 5.72e-06 | 32 |
GO:190305116 | Prostate | Tumor | negative regulation of proteolysis involved in cellular protein catabolic process | 28/3246 | 64/18723 | 7.39e-07 | 1.47e-05 | 28 |
GO:190357318 | Prostate | Tumor | negative regulation of response to endoplasmic reticulum stress | 21/3246 | 44/18723 | 3.25e-06 | 5.31e-05 | 21 |
GO:003243513 | Prostate | Tumor | negative regulation of proteasomal ubiquitin-dependent protein catabolic process | 18/3246 | 35/18723 | 4.26e-06 | 6.72e-05 | 18 |
GO:190179912 | Prostate | Tumor | negative regulation of proteasomal protein catabolic process | 21/3246 | 49/18723 | 2.59e-05 | 3.18e-04 | 21 |
GO:000647014 | Prostate | Tumor | protein dephosphorylation | 76/3246 | 281/18723 | 2.86e-05 | 3.46e-04 | 76 |
GO:005134617 | Prostate | Tumor | negative regulation of hydrolase activity | 97/3246 | 379/18723 | 2.87e-05 | 3.46e-04 | 97 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
USP14 | SNV | Missense_Mutation | novel | c.1482N>C | p.Gln494His | p.Q494H | P54578 | protein_coding | tolerated_low_confidence(0.23) | benign(0.005) | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
USP14 | insertion | In_Frame_Ins | novel | c.1484_1485insACAGGAGAACCC | p.Ter495delinsTer | p.*495delins* | P54578 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
USP14 | deletion | Frame_Shift_Del | novel | c.874delN | p.Leu292CysfsTer33 | p.L292Cfs*33 | P54578 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
USP14 | SNV | Missense_Mutation | rs374300842 | c.760N>G | p.Thr254Ala | p.T254A | P54578 | protein_coding | tolerated(0.36) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
USP14 | SNV | Missense_Mutation | c.40N>C | p.Lys14Gln | p.K14Q | P54578 | protein_coding | tolerated(0.13) | possibly_damaging(0.823) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
USP14 | SNV | Missense_Mutation | c.911N>T | p.Thr304Met | p.T304M | P54578 | protein_coding | deleterious(0.01) | possibly_damaging(0.896) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
USP14 | SNV | Missense_Mutation | novel | c.288N>T | p.Gln96His | p.Q96H | P54578 | protein_coding | deleterious(0) | possibly_damaging(0.679) | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
USP14 | insertion | Nonsense_Mutation | novel | c.286_287insACATATAACATAATTCT | p.Gln96HisfsTer3 | p.Q96Hfs*3 | P54578 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
USP14 | insertion | Frame_Shift_Ins | novel | c.990_991insT | p.Tyr333LeufsTer2 | p.Y333Lfs*2 | P54578 | protein_coding | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
USP14 | SNV | Missense_Mutation | novel | c.1384N>T | p.Asp462Tyr | p.D462Y | P54578 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9097 | USP14 | ENZYME, CELL SURFACE, PROTEASE | inhibitor | 252827537 | ||
9097 | USP14 | ENZYME, CELL SURFACE, PROTEASE | PMID26077642-Compound-Figure3A | |||
9097 | USP14 | ENZYME, CELL SURFACE, PROTEASE | inhibitor | 328083515 | ||
9097 | USP14 | ENZYME, CELL SURFACE, PROTEASE | Tricyclic heterocycle derivative 4 |
Page: 1 |