![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TMPRSS4 |
Gene summary for TMPRSS4 |
![]() |
Gene information | Species | Human | Gene symbol | TMPRSS4 | Gene ID | 56649 |
Gene name | transmembrane serine protease 4 | |
Gene Alias | CAP2 | |
Cytomap | 11q23.3 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | Q9NRS4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
56649 | TMPRSS4 | CA_HPV_2 | Human | Cervix | CC | 2.95e-04 | 2.88e-01 | 0.0391 |
56649 | TMPRSS4 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 2.04e-02 | -1.35e-01 | 0.0116 |
56649 | TMPRSS4 | CCI_1 | Human | Cervix | CC | 2.20e-09 | 1.04e+00 | 0.528 |
56649 | TMPRSS4 | CCI_2 | Human | Cervix | CC | 1.33e-02 | 6.81e-01 | 0.5249 |
56649 | TMPRSS4 | Tumor | Human | Cervix | CC | 6.25e-09 | 3.82e-01 | 0.1241 |
56649 | TMPRSS4 | sample3 | Human | Cervix | CC | 1.23e-38 | 6.78e-01 | 0.1387 |
56649 | TMPRSS4 | H2 | Human | Cervix | HSIL_HPV | 2.84e-18 | 5.51e-01 | 0.0632 |
56649 | TMPRSS4 | T3 | Human | Cervix | CC | 2.61e-30 | 6.52e-01 | 0.1389 |
56649 | TMPRSS4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.44e-09 | -4.88e-01 | 0.0155 |
56649 | TMPRSS4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.18e-10 | 7.91e-01 | -0.0811 |
56649 | TMPRSS4 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.74e-05 | 5.99e-01 | -0.1088 |
56649 | TMPRSS4 | HTA11_347_2000001011 | Human | Colorectum | AD | 4.29e-39 | 1.17e+00 | -0.1954 |
56649 | TMPRSS4 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.04e-09 | 1.22e+00 | -0.2602 |
56649 | TMPRSS4 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.90e-04 | 6.26e-01 | -0.1526 |
56649 | TMPRSS4 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.79e-07 | 5.71e-01 | -0.1464 |
56649 | TMPRSS4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.07e-02 | 5.84e-01 | -0.059 |
56649 | TMPRSS4 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.60e-02 | 8.79e-01 | 0.3487 |
56649 | TMPRSS4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.54e-13 | 9.52e-01 | 0.3859 |
56649 | TMPRSS4 | F007 | Human | Colorectum | FAP | 1.60e-08 | -5.12e-01 | 0.1176 |
56649 | TMPRSS4 | A002-C-010 | Human | Colorectum | FAP | 2.88e-10 | -4.21e-01 | 0.242 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004440320 | Oral cavity | OSCC | biological process involved in symbiotic interaction | 173/7305 | 290/18723 | 6.80e-13 | 3.19e-11 | 173 |
GO:005079220 | Oral cavity | OSCC | regulation of viral process | 109/7305 | 164/18723 | 8.95e-13 | 4.10e-11 | 109 |
GO:005160410 | Oral cavity | OSCC | protein maturation | 170/7305 | 294/18723 | 3.97e-11 | 1.28e-09 | 170 |
GO:190390020 | Oral cavity | OSCC | regulation of viral life cycle | 97/7305 | 148/18723 | 5.34e-11 | 1.67e-09 | 97 |
GO:005170120 | Oral cavity | OSCC | biological process involved in interaction with host | 125/7305 | 203/18723 | 5.60e-11 | 1.74e-09 | 125 |
GO:004852417 | Oral cavity | OSCC | positive regulation of viral process | 51/7305 | 65/18723 | 9.56e-11 | 2.90e-09 | 51 |
GO:005212620 | Oral cavity | OSCC | movement in host environment | 106/7305 | 175/18723 | 5.84e-09 | 1.26e-07 | 106 |
GO:00459266 | Oral cavity | OSCC | negative regulation of growth | 135/7305 | 249/18723 | 7.29e-07 | 1.03e-05 | 135 |
GO:00164856 | Oral cavity | OSCC | protein processing | 121/7305 | 225/18723 | 4.56e-06 | 5.23e-05 | 121 |
GO:004440920 | Oral cavity | OSCC | entry into host | 86/7305 | 151/18723 | 5.74e-06 | 6.37e-05 | 86 |
GO:004671820 | Oral cavity | OSCC | viral entry into host cell | 81/7305 | 144/18723 | 1.98e-05 | 1.89e-04 | 81 |
GO:19039029 | Oral cavity | OSCC | positive regulation of viral life cycle | 22/7305 | 29/18723 | 6.05e-05 | 4.95e-04 | 22 |
GO:004390319 | Oral cavity | OSCC | regulation of biological process involved in symbiotic interaction | 44/7305 | 72/18723 | 1.20e-04 | 8.57e-04 | 44 |
GO:005237217 | Oral cavity | OSCC | modulation by symbiont of entry into host | 28/7305 | 49/18723 | 7.63e-03 | 2.79e-02 | 28 |
GO:0016032110 | Oral cavity | LP | viral process | 211/4623 | 415/18723 | 4.06e-31 | 3.18e-28 | 211 |
GO:0019058110 | Oral cavity | LP | viral life cycle | 161/4623 | 317/18723 | 5.99e-24 | 2.21e-21 | 161 |
GO:0051701110 | Oral cavity | LP | biological process involved in interaction with host | 100/4623 | 203/18723 | 2.72e-14 | 3.10e-12 | 100 |
GO:0044403110 | Oral cavity | LP | biological process involved in symbiotic interaction | 130/4623 | 290/18723 | 4.23e-14 | 4.64e-12 | 130 |
GO:0050792110 | Oral cavity | LP | regulation of viral process | 83/4623 | 164/18723 | 6.50e-13 | 5.74e-11 | 83 |
GO:0052126110 | Oral cavity | LP | movement in host environment | 87/4623 | 175/18723 | 6.65e-13 | 5.79e-11 | 87 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516414 | Cervix | CC | Influenza A | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0516415 | Cervix | CC | Influenza A | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0516422 | Cervix | HSIL_HPV | Influenza A | 23/459 | 171/8465 | 4.65e-05 | 6.48e-04 | 5.24e-04 | 23 |
hsa0516432 | Cervix | HSIL_HPV | Influenza A | 23/459 | 171/8465 | 4.65e-05 | 6.48e-04 | 5.24e-04 | 23 |
hsa0516420 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa05164110 | Esophagus | HGIN | Influenza A | 42/1383 | 171/8465 | 3.41e-03 | 2.54e-02 | 2.02e-02 | 42 |
hsa0516425 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa0516435 | Esophagus | ESCC | Influenza A | 122/4205 | 171/8465 | 5.01e-09 | 4.79e-08 | 2.45e-08 | 122 |
hsa0516412 | Lung | IAC | Influenza A | 35/1053 | 171/8465 | 1.82e-03 | 1.00e-02 | 6.66e-03 | 35 |
hsa0516413 | Lung | IAC | Influenza A | 35/1053 | 171/8465 | 1.82e-03 | 1.00e-02 | 6.66e-03 | 35 |
hsa0516418 | Oral cavity | OSCC | Influenza A | 116/3704 | 171/8465 | 1.23e-10 | 1.78e-09 | 9.08e-10 | 116 |
hsa0516419 | Oral cavity | OSCC | Influenza A | 116/3704 | 171/8465 | 1.23e-10 | 1.78e-09 | 9.08e-10 | 116 |
hsa0516424 | Oral cavity | LP | Influenza A | 80/2418 | 171/8465 | 2.56e-07 | 3.41e-06 | 2.20e-06 | 80 |
hsa0516434 | Oral cavity | LP | Influenza A | 80/2418 | 171/8465 | 2.56e-07 | 3.41e-06 | 2.20e-06 | 80 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TMPRSS4 | SNV | Missense_Mutation | c.1186N>A | p.Asp396Asn | p.D396N | Q9NRS4 | protein_coding | tolerated(0.29) | possibly_damaging(0.505) | TCGA-A2-A0YT-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | arimidex | SD | |
TMPRSS4 | SNV | Missense_Mutation | c.295N>C | p.Gly99Arg | p.G99R | Q9NRS4 | protein_coding | tolerated(0.11) | benign(0.003) | TCGA-AN-A0XU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
TMPRSS4 | SNV | Missense_Mutation | novel | c.1109T>G | p.Met370Arg | p.M370R | Q9NRS4 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
TMPRSS4 | SNV | Missense_Mutation | rs781599975 | c.673N>A | p.Asp225Asn | p.D225N | Q9NRS4 | protein_coding | tolerated(0.97) | benign(0.003) | TCGA-E9-A1R0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
TMPRSS4 | SNV | Missense_Mutation | novel | c.1037N>T | p.Ala346Val | p.A346V | Q9NRS4 | protein_coding | deleterious(0) | possibly_damaging(0.632) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TMPRSS4 | SNV | Missense_Mutation | rs774877636 | c.341N>G | p.Gln114Arg | p.Q114R | Q9NRS4 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
TMPRSS4 | SNV | Missense_Mutation | c.523N>T | p.Arg175Cys | p.R175C | Q9NRS4 | protein_coding | deleterious(0) | benign(0.394) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TMPRSS4 | SNV | Missense_Mutation | rs144820624 | c.524N>A | p.Arg175His | p.R175H | Q9NRS4 | protein_coding | tolerated(0.17) | benign(0) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TMPRSS4 | SNV | Missense_Mutation | rs762712812 | c.1289N>G | p.Tyr430Cys | p.Y430C | Q9NRS4 | protein_coding | deleterious(0) | possibly_damaging(0.784) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TMPRSS4 | SNV | Missense_Mutation | novel | c.939C>A | p.Phe313Leu | p.F313L | Q9NRS4 | protein_coding | deleterious(0.01) | benign(0.406) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |