Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/SLC7A1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/SLC7A1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SLC7A1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SLC7A1_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/SLC7A1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SLC7A1_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SLC7A1_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004578518 | Prostate | BPH | positive regulation of cell adhesion | 120/3107 | 437/18723 | 5.22e-09 | 1.90e-07 | 120 |
GO:000226218 | Prostate | BPH | myeloid cell homeostasis | 54/3107 | 157/18723 | 4.02e-08 | 1.12e-06 | 54 |
GO:004887218 | Prostate | BPH | homeostasis of number of cells | 79/3107 | 272/18723 | 1.79e-07 | 3.99e-06 | 79 |
GO:007099718 | Prostate | BPH | neuron death | 98/3107 | 361/18723 | 2.35e-07 | 5.12e-06 | 98 |
GO:190547510 | Prostate | BPH | regulation of protein localization to membrane | 55/3107 | 175/18723 | 8.75e-07 | 1.61e-05 | 55 |
GO:190121418 | Prostate | BPH | regulation of neuron death | 87/3107 | 319/18723 | 8.86e-07 | 1.63e-05 | 87 |
GO:003410917 | Prostate | BPH | homotypic cell-cell adhesion | 33/3107 | 90/18723 | 3.45e-06 | 5.41e-05 | 33 |
GO:002240716 | Prostate | BPH | regulation of cell-cell adhesion | 109/3107 | 448/18723 | 1.43e-05 | 1.85e-04 | 109 |
GO:19032039 | Prostate | BPH | regulation of oxidative stress-induced neuron death | 14/3107 | 27/18723 | 2.69e-05 | 3.16e-04 | 14 |
GO:00508087 | Prostate | BPH | synapse organization | 103/3107 | 426/18723 | 3.19e-05 | 3.61e-04 | 103 |
GO:00991736 | Prostate | BPH | postsynapse organization | 49/3107 | 168/18723 | 3.20e-05 | 3.61e-04 | 49 |
GO:00364759 | Prostate | BPH | neuron death in response to oxidative stress | 15/3107 | 31/18723 | 4.00e-05 | 4.30e-04 | 15 |
GO:190320116 | Prostate | BPH | regulation of oxidative stress-induced cell death | 26/3107 | 74/18723 | 8.40e-05 | 8.01e-04 | 26 |
GO:000963616 | Prostate | BPH | response to toxic substance | 67/3107 | 262/18723 | 1.32e-04 | 1.18e-03 | 67 |
GO:000931414 | Prostate | BPH | response to radiation | 105/3107 | 456/18723 | 2.07e-04 | 1.70e-03 | 105 |
GO:004211010 | Prostate | BPH | T cell activation | 111/3107 | 487/18723 | 2.11e-04 | 1.72e-03 | 111 |
GO:003647317 | Prostate | BPH | cell death in response to oxidative stress | 30/3107 | 95/18723 | 2.29e-04 | 1.83e-03 | 30 |
GO:005087817 | Prostate | BPH | regulation of body fluid levels | 89/3107 | 379/18723 | 3.08e-04 | 2.37e-03 | 89 |
GO:007052716 | Prostate | BPH | platelet aggregation | 23/3107 | 67/18723 | 3.12e-04 | 2.39e-03 | 23 |
GO:19032049 | Prostate | BPH | negative regulation of oxidative stress-induced neuron death | 10/3107 | 19/18723 | 3.36e-04 | 2.52e-03 | 10 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC7A1 | SNV | Missense_Mutation | | c.623N>A | p.Gly208Glu | p.G208E | P30825 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC7A1 | insertion | Nonsense_Mutation | novel | c.1165_1166insTTTAAATTTGTTTTAGTTGCAGTGATCTAGAGGGGCTTGA | p.Thr389IlefsTer2 | p.T389Ifs*2 | P30825 | protein_coding | | | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SLC7A1 | insertion | Frame_Shift_Ins | novel | c.1601_1602insTAAAT | p.Ser535LysfsTer37 | p.S535Kfs*37 | P30825 | protein_coding | | | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SLC7A1 | insertion | In_Frame_Ins | novel | c.1600_1601insTCCCTCCGGGGTGGTGGGATGCTTCTC | p.Gly534delinsValProProGlyTrpTrpAspAlaSerArg | p.G534delinsVPPGWWDASR | P30825 | protein_coding | | | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
SLC7A1 | insertion | In_Frame_Ins | novel | c.373_374insAAACGATGAGAGGCGTCCATGGCAGAGCAGTGGTCT | p.Thr125delinsLysThrMetArgGlyValHisGlyArgAlaValValSer | p.T125delinsKTMRGVHGRAVVS | P30825 | protein_coding | | | TCGA-BH-A0EB-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
SLC7A1 | SNV | Missense_Mutation | novel | c.874G>A | p.Ala292Thr | p.A292T | P30825 | protein_coding | tolerated(0.29) | possibly_damaging(0.555) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC7A1 | SNV | Missense_Mutation | | c.308N>C | p.Val103Ala | p.V103A | P30825 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC7A1 | SNV | Missense_Mutation | rs767310993 | c.817N>A | p.Ala273Thr | p.A273T | P30825 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
SLC7A1 | SNV | Missense_Mutation | rs548607156 | c.1633N>A | p.Val545Ile | p.V545I | P30825 | protein_coding | tolerated(1) | benign(0) | TCGA-WL-A834-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
SLC7A1 | SNV | Missense_Mutation | | c.44G>A | p.Arg15Gln | p.R15Q | P30825 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A6-3810-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |