Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: SAFB

Gene summary for SAFB

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

SAFB

Gene ID

6294

Gene namescaffold attachment factor B
Gene AliasHAP
Cytomap19p13.3
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

Q15424


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
6294SAFBHTA11_866_3004761011HumanColorectumAD6.70e-064.00e-010.096
6294SAFBHTA11_7696_3000711011HumanColorectumAD5.62e-054.60e-010.0674
6294SAFBHTA11_99999965104_69814HumanColorectumMSS2.56e-023.85e-010.281
6294SAFBHTA11_99999971662_82457HumanColorectumMSS1.14e-045.07e-010.3859
6294SAFBA015-C-203HumanColorectumFAP3.40e-18-1.63e-01-0.1294
6294SAFBA002-C-201HumanColorectumFAP6.84e-04-1.17e-010.0324
6294SAFBA001-C-119HumanColorectumFAP4.71e-033.69e-02-0.1557
6294SAFBA001-C-108HumanColorectumFAP3.31e-09-9.64e-02-0.0272
6294SAFBA002-C-205HumanColorectumFAP2.65e-10-1.68e-01-0.1236
6294SAFBA015-C-006HumanColorectumFAP1.62e-06-1.72e-01-0.0994
6294SAFBA015-C-106HumanColorectumFAP6.29e-04-7.40e-02-0.0511
6294SAFBA002-C-114HumanColorectumFAP6.37e-09-7.88e-02-0.1561
6294SAFBA015-C-104HumanColorectumFAP2.09e-20-9.30e-02-0.1899
6294SAFBA001-C-014HumanColorectumFAP3.30e-05-1.15e-010.0135
6294SAFBA002-C-016HumanColorectumFAP4.35e-13-2.50e-010.0521
6294SAFBA015-C-002HumanColorectumFAP2.49e-04-2.00e-01-0.0763
6294SAFBA001-C-203HumanColorectumFAP2.13e-04-7.60e-02-0.0481
6294SAFBA002-C-116HumanColorectumFAP2.19e-17-1.48e-01-0.0452
6294SAFBA014-C-008HumanColorectumFAP1.73e-068.48e-03-0.191
6294SAFBA018-E-020HumanColorectumFAP1.30e-08-1.43e-01-0.2034
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0030518111ThyroidPTCintracellular steroid hormone receptor signaling pathway63/5968116/187234.53e-077.41e-0663
GO:0071383112ThyroidPTCcellular response to steroid hormone stimulus98/5968204/187239.83e-071.47e-0598
GO:004340124ThyroidPTCsteroid hormone mediated signaling pathway69/5968136/187233.57e-064.58e-0569
GO:003314310ThyroidPTCregulation of intracellular steroid hormone receptor signaling pathway42/596874/187238.40e-069.62e-0542
GO:0061458112ThyroidPTCreproductive system development173/5968427/187238.70e-057.23e-04173
GO:0048608111ThyroidPTCreproductive structure development170/5968424/187231.86e-041.41e-03170
GO:0030521111ThyroidPTCandrogen receptor signaling pathway25/596844/187235.43e-043.48e-0325
GO:00305209ThyroidPTCintracellular estrogen receptor signaling pathway28/596854/187231.79e-039.68e-0328
GO:000975519ThyroidPTChormone-mediated signaling pathway80/5968190/187231.84e-039.91e-0380
GO:004654612ThyroidPTCdevelopment of primary male sexual characteristics60/5968142/187235.79e-032.61e-0260
GO:000858412ThyroidPTCmale gonad development59/5968141/187237.88e-033.33e-0259
GO:00600083ThyroidPTCSertoli cell differentiation11/596818/187231.00e-024.07e-0211
GO:190331134ThyroidATCregulation of mRNA metabolic process181/6293288/187231.75e-245.54e-22181
GO:005068434ThyroidATCregulation of mRNA processing97/6293137/187235.28e-197.25e-1797
GO:0048545210ThyroidATCresponse to steroid hormone168/6293339/187237.21e-101.88e-08168
GO:0030522112ThyroidATCintracellular receptor signaling pathway134/6293265/187237.58e-091.63e-07134
GO:0006325110ThyroidATCchromatin organization189/6293409/187236.40e-081.13e-06189
GO:006145827ThyroidATCreproductive system development193/6293427/187233.32e-074.92e-06193
GO:007138328ThyroidATCcellular response to steroid hormone stimulus103/6293204/187234.32e-076.30e-06103
GO:003051826ThyroidATCintracellular steroid hormone receptor signaling pathway65/6293116/187235.58e-077.93e-0665
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
SAFBSNVMissense_Mutationrs770745797c.502N>Ap.Glu168Lysp.E168KQ15424protein_codingtolerated(0.39)benign(0.372)TCGA-AC-A7VC-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SAFBSNVMissense_Mutationc.2311N>Tp.Met771Leup.M771LQ15424protein_codingtolerated(0.12)benign(0.003)TCGA-AN-A041-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
SAFBSNVMissense_Mutationc.1825N>Gp.Lys609Glup.K609EQ15424protein_codingdeleterious(0)probably_damaging(0.983)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
SAFBSNVMissense_Mutationc.1534N>Gp.Asn512Aspp.N512DQ15424protein_codingtolerated(0.45)benign(0.029)TCGA-AR-A24Q-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
SAFBSNVMissense_Mutationc.1471A>Tp.Thr491Serp.T491SQ15424protein_codingtolerated(0.61)benign(0.017)TCGA-E9-A3HO-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamideCR
SAFBinsertionFrame_Shift_Insnovelc.2290_2291insTGAGACTCp.Arg764MetfsTer11p.R764Mfs*11Q15424protein_codingTCGA-A2-A0EO-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
SAFBinsertionFrame_Shift_Insnovelc.2330_2331insATp.Gln778TyrfsTer31p.Q778Yfs*31Q15424protein_codingTCGA-A2-A0EY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
SAFBinsertionNonsense_Mutationnovelc.2332_2333insAATGCAACTTCTATAAAGGGCCTTGTAAACTGTTCTp.Gln778_His779insCysAsnPheTyrLysGlyProCysLysLeuPheTerp.Q778_H779insCNFYKGPCKLF*Q15424protein_codingTCGA-A2-A0EY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
SAFBinsertionFrame_Shift_Insnovelc.178_179insTTTTCAACAAACCAACAAAAAAATGCAATACCCATCTAGTAACCAAAp.Arg60LeufsTer18p.R60Lfs*18Q15424protein_codingTCGA-BH-A0B1-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapyadriamycinSD
SAFBdeletionFrame_Shift_Delnovelc.602delNp.Ile201AsnfsTer30p.I201Nfs*30Q15424protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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