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Gene: PNP |
Gene summary for PNP |
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Gene information | Species | Human | Gene symbol | PNP | Gene ID | 4860 |
Gene name | purine nucleoside phosphorylase | |
Gene Alias | NP | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000255 | UniProtAcc | P00491 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4860 | PNP | LZE5T | Human | Esophagus | ESCC | 2.61e-04 | -2.12e-01 | 0.0514 |
4860 | PNP | LZE7T | Human | Esophagus | ESCC | 1.30e-04 | 4.39e-02 | 0.0667 |
4860 | PNP | LZE8T | Human | Esophagus | ESCC | 3.72e-02 | -1.81e-01 | 0.067 |
4860 | PNP | LZE20T | Human | Esophagus | ESCC | 4.33e-05 | -6.62e-02 | 0.0662 |
4860 | PNP | LZE22D1 | Human | Esophagus | HGIN | 8.91e-05 | -3.66e-01 | 0.0595 |
4860 | PNP | P2T-E | Human | Esophagus | ESCC | 3.23e-05 | 3.00e-01 | 0.1177 |
4860 | PNP | P4T-E | Human | Esophagus | ESCC | 2.76e-14 | 9.17e-01 | 0.1323 |
4860 | PNP | P5T-E | Human | Esophagus | ESCC | 7.78e-13 | 6.22e-01 | 0.1327 |
4860 | PNP | P8T-E | Human | Esophagus | ESCC | 2.62e-05 | -7.14e-02 | 0.0889 |
4860 | PNP | P10T-E | Human | Esophagus | ESCC | 8.64e-04 | -2.14e-01 | 0.116 |
4860 | PNP | P11T-E | Human | Esophagus | ESCC | 2.32e-08 | 1.17e+00 | 0.1426 |
4860 | PNP | P12T-E | Human | Esophagus | ESCC | 1.55e-04 | 2.69e-01 | 0.1122 |
4860 | PNP | P15T-E | Human | Esophagus | ESCC | 7.28e-14 | 7.41e-01 | 0.1149 |
4860 | PNP | P16T-E | Human | Esophagus | ESCC | 3.18e-05 | 7.02e-02 | 0.1153 |
4860 | PNP | P21T-E | Human | Esophagus | ESCC | 3.63e-14 | 4.45e-01 | 0.1617 |
4860 | PNP | P22T-E | Human | Esophagus | ESCC | 7.28e-03 | 1.98e-01 | 0.1236 |
4860 | PNP | P23T-E | Human | Esophagus | ESCC | 5.50e-03 | 3.36e-01 | 0.108 |
4860 | PNP | P24T-E | Human | Esophagus | ESCC | 4.31e-03 | 2.39e-01 | 0.1287 |
4860 | PNP | P26T-E | Human | Esophagus | ESCC | 1.67e-07 | 4.57e-01 | 0.1276 |
4860 | PNP | P27T-E | Human | Esophagus | ESCC | 1.88e-11 | 5.75e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00194322 | Liver | NAFLD | triglyceride biosynthetic process | 13/1882 | 42/18723 | 1.60e-04 | 2.94e-03 | 13 |
GO:00464612 | Liver | NAFLD | neutral lipid catabolic process | 12/1882 | 39/18723 | 3.02e-04 | 4.75e-03 | 12 |
GO:00464642 | Liver | NAFLD | acylglycerol catabolic process | 12/1882 | 39/18723 | 3.02e-04 | 4.75e-03 | 12 |
GO:00621977 | Liver | NAFLD | cellular response to chemical stress | 54/1882 | 337/18723 | 3.83e-04 | 5.73e-03 | 54 |
GO:00450174 | Liver | NAFLD | glycerolipid biosynthetic process | 43/1882 | 252/18723 | 3.83e-04 | 5.73e-03 | 43 |
GO:00335596 | Liver | NAFLD | unsaturated fatty acid metabolic process | 24/1882 | 116/18723 | 4.64e-04 | 6.74e-03 | 24 |
GO:00016763 | Liver | NAFLD | long-chain fatty acid metabolic process | 23/1882 | 112/18723 | 6.73e-04 | 8.66e-03 | 23 |
GO:00464601 | Liver | NAFLD | neutral lipid biosynthetic process | 13/1882 | 50/18723 | 1.04e-03 | 1.22e-02 | 13 |
GO:00464631 | Liver | NAFLD | acylglycerol biosynthetic process | 13/1882 | 50/18723 | 1.04e-03 | 1.22e-02 | 13 |
GO:00345997 | Liver | NAFLD | cellular response to oxidative stress | 46/1882 | 288/18723 | 1.07e-03 | 1.25e-02 | 46 |
GO:01202545 | Liver | NAFLD | olefinic compound metabolic process | 28/1882 | 153/18723 | 1.28e-03 | 1.45e-02 | 28 |
GO:00066334 | Liver | NAFLD | fatty acid biosynthetic process | 29/1882 | 163/18723 | 1.67e-03 | 1.74e-02 | 29 |
GO:0046434 | Liver | NAFLD | organophosphate catabolic process | 27/1882 | 155/18723 | 3.21e-03 | 2.86e-02 | 27 |
GO:00465032 | Liver | NAFLD | glycerolipid catabolic process | 14/1882 | 65/18723 | 4.57e-03 | 3.68e-02 | 14 |
GO:00066906 | Liver | NAFLD | icosanoid metabolic process | 22/1882 | 123/18723 | 5.33e-03 | 4.11e-02 | 22 |
GO:00194332 | Liver | NAFLD | triglyceride catabolic process | 8/1882 | 29/18723 | 6.40e-03 | 4.69e-02 | 8 |
GO:00464742 | Liver | NAFLD | glycerophospholipid biosynthetic process | 33/1882 | 211/18723 | 6.93e-03 | 4.88e-02 | 33 |
GO:000989612 | Liver | Cirrhotic | positive regulation of catabolic process | 215/4634 | 492/18723 | 1.13e-20 | 3.56e-18 | 215 |
GO:190136111 | Liver | Cirrhotic | organic cyclic compound catabolic process | 213/4634 | 495/18723 | 1.58e-19 | 3.67e-17 | 213 |
GO:003133112 | Liver | Cirrhotic | positive regulation of cellular catabolic process | 190/4634 | 427/18723 | 1.94e-19 | 4.18e-17 | 190 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PNP | SNV | Missense_Mutation | novel | c.416N>T | p.Pro139Leu | p.P139L | P00491 | protein_coding | tolerated(0.53) | benign(0.298) | TCGA-BH-A0HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
PNP | insertion | Nonsense_Mutation | novel | c.801_802insCCCCTTGTTCAGTAGCCTCTTCTTTAAGAA | p.Ala267_Ala268insProLeuValGlnTerProLeuLeuTerGlu | p.A267_A268insPLVQ*PLL*E | P00491 | protein_coding | TCGA-AN-A03X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PNP | deletion | Frame_Shift_Del | novel | c.134delN | p.Gln46ArgfsTer28 | p.Q46Rfs*28 | P00491 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
PNP | SNV | Missense_Mutation | novel | c.611C>T | p.Ala204Val | p.A204V | P00491 | protein_coding | deleterious(0) | benign(0.158) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
PNP | SNV | Missense_Mutation | rs150531909 | c.482N>T | p.Ala161Val | p.A161V | P00491 | protein_coding | tolerated(0.07) | benign(0.183) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PNP | SNV | Missense_Mutation | c.839N>T | p.Ala280Val | p.A280V | P00491 | protein_coding | tolerated(0.16) | benign(0.012) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PNP | SNV | Missense_Mutation | rs755640590 | c.646N>A | p.Ala216Thr | p.A216T | P00491 | protein_coding | deleterious(0.05) | probably_damaging(0.914) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PNP | SNV | Missense_Mutation | novel | c.71N>A | p.Arg24Gln | p.R24Q | P00491 | protein_coding | tolerated(0.06) | benign(0.021) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PNP | SNV | Missense_Mutation | rs769652649 | c.472N>T | p.Arg158Cys | p.R158C | P00491 | protein_coding | deleterious(0) | possibly_damaging(0.792) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PNP | SNV | Missense_Mutation | novel | c.819N>T | p.Gln273His | p.Q273H | P00491 | protein_coding | deleterious(0.03) | benign(0.003) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4860 | PNP | ENZYME, DRUGGABLE GENOME | inhibitor | CHEMBL550755 | FORODESINE HYDROCHLORIDE | |
4860 | PNP | ENZYME, DRUGGABLE GENOME | Guanosine | GUANOSINE | ||
4860 | PNP | ENZYME, DRUGGABLE GENOME | ULODESINE | ULODESINE | ||
4860 | PNP | ENZYME, DRUGGABLE GENOME | FORODESINE | FORODESINE | ||
4860 | PNP | ENZYME, DRUGGABLE GENOME | BCX-3408 | ULODESINE | ||
4860 | PNP | ENZYME, DRUGGABLE GENOME | 2'3'-Dideoxyinosine | |||
4860 | PNP | ENZYME, DRUGGABLE GENOME | FORODESINE HYDROCHLORIDE | FORODESINE HYDROCHLORIDE | 19386496,19386498 | |
4860 | PNP | ENZYME, DRUGGABLE GENOME | Peldesine | PELDESINE | ||
4860 | PNP | ENZYME, DRUGGABLE GENOME | inhibitor | 252166484 | FORODESINE | |
4860 | PNP | ENZYME, DRUGGABLE GENOME | Forodesine | FORODESINE |
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