Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NIN_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NIN_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NIN_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/NIN_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NIN_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/NIN_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0034454 | Oral cavity | EOLP | microtubule anchoring at centrosome | 5/2218 | 11/18723 | 5.79e-03 | 2.94e-02 | 5 |
GO:006056015 | Oral cavity | EOLP | developmental growth involved in morphogenesis | 41/2218 | 234/18723 | 6.54e-03 | 3.21e-02 | 41 |
GO:003111011 | Oral cavity | EOLP | regulation of microtubule polymerization or depolymerization | 19/2218 | 88/18723 | 6.55e-03 | 3.21e-02 | 19 |
GO:000740910 | Oral cavity | EOLP | axonogenesis | 66/2218 | 418/18723 | 8.99e-03 | 4.13e-02 | 66 |
GO:005077212 | Oral cavity | EOLP | positive regulation of axonogenesis | 17/2218 | 79/18723 | 1.01e-02 | 4.55e-02 | 17 |
GO:006156414 | Oral cavity | EOLP | axon development | 72/2218 | 467/18723 | 1.14e-02 | 5.00e-02 | 72 |
GO:190290334 | Oral cavity | NEOLP | regulation of supramolecular fiber organization | 88/2005 | 383/18723 | 2.44e-12 | 4.83e-10 | 88 |
GO:004325432 | Oral cavity | NEOLP | regulation of protein-containing complex assembly | 95/2005 | 428/18723 | 2.76e-12 | 5.29e-10 | 95 |
GO:003133433 | Oral cavity | NEOLP | positive regulation of protein-containing complex assembly | 58/2005 | 237/18723 | 1.09e-09 | 7.92e-08 | 58 |
GO:190290533 | Oral cavity | NEOLP | positive regulation of supramolecular fiber organization | 53/2005 | 209/18723 | 1.47e-09 | 1.01e-07 | 53 |
GO:003227133 | Oral cavity | NEOLP | regulation of protein polymerization | 57/2005 | 233/18723 | 1.54e-09 | 1.03e-07 | 57 |
GO:005125833 | Oral cavity | NEOLP | protein polymerization | 67/2005 | 297/18723 | 2.27e-09 | 1.40e-07 | 67 |
GO:003227333 | Oral cavity | NEOLP | positive regulation of protein polymerization | 37/2005 | 138/18723 | 9.19e-08 | 3.43e-06 | 37 |
GO:001604931 | Oral cavity | NEOLP | cell growth | 90/2005 | 482/18723 | 9.23e-08 | 3.43e-06 | 90 |
GO:005149532 | Oral cavity | NEOLP | positive regulation of cytoskeleton organization | 50/2005 | 226/18723 | 4.47e-07 | 1.35e-05 | 50 |
GO:001072031 | Oral cavity | NEOLP | positive regulation of cell development | 59/2005 | 298/18723 | 2.21e-06 | 5.13e-05 | 59 |
GO:001097521 | Oral cavity | NEOLP | regulation of neuron projection development | 77/2005 | 445/18723 | 1.44e-05 | 2.53e-04 | 77 |
GO:003111631 | Oral cavity | NEOLP | positive regulation of microtubule polymerization | 13/2005 | 33/18723 | 1.70e-05 | 2.88e-04 | 13 |
GO:003090013 | Oral cavity | NEOLP | forebrain development | 67/2005 | 379/18723 | 2.54e-05 | 3.99e-04 | 67 |
GO:004678531 | Oral cavity | NEOLP | microtubule polymerization | 22/2005 | 83/18723 | 4.31e-05 | 6.10e-04 | 22 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NIN | SNV | Missense_Mutation | novel | c.4249C>G | p.Gln1417Glu | p.Q1417E | Q8N4C6 | protein_coding | tolerated(0.58) | benign(0) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
NIN | SNV | Missense_Mutation | | c.51N>G | p.Phe17Leu | p.F17L | Q8N4C6 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A8-A06U-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NIN | SNV | Missense_Mutation | novel | c.2894C>G | p.Ala965Gly | p.A965G | Q8N4C6 | protein_coding | tolerated(0.21) | benign(0.006) | TCGA-A8-A096-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NIN | SNV | Missense_Mutation | novel | c.517N>A | p.Gln173Lys | p.Q173K | Q8N4C6 | protein_coding | tolerated(0.14) | benign(0.006) | TCGA-AC-A5EH-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NIN | SNV | Missense_Mutation | | c.3568N>G | p.Arg1190Gly | p.R1190G | Q8N4C6 | protein_coding | tolerated(0.09) | possibly_damaging(0.573) | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NIN | SNV | Missense_Mutation | novel | c.4658N>T | p.Glu1553Val | p.E1553V | Q8N4C6 | protein_coding | deleterious(0) | benign(0.219) | TCGA-C8-A1HJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NIN | SNV | Missense_Mutation | novel | c.4739N>T | p.Ser1580Leu | p.S1580L | Q8N4C6 | protein_coding | tolerated(0.13) | benign(0.069) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NIN | SNV | Missense_Mutation | | c.1444N>A | p.Arg482Ser | p.R482S | Q8N4C6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1J9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NIN | SNV | Missense_Mutation | rs774918630 | c.6116N>A | p.Arg2039Gln | p.R2039Q | Q8N4C6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
NIN | SNV | Missense_Mutation | | c.5731N>C | p.Glu1911Gln | p.E1911Q | Q8N4C6 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |