Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MCU

Gene summary for MCU

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MCU

Gene ID

90550

Gene namemitochondrial calcium uniporter
Gene AliasC10orf42
Cytomap10q22.1
Gene Typeprotein-coding
GO ID

GO:0000266

UniProtAcc

Q8NE86


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
90550MCUCCI_1HumanCervixCC8.85e-141.09e+000.528
90550MCUCCI_2HumanCervixCC2.73e-088.07e-010.5249
90550MCUCCI_3HumanCervixCC2.83e-085.44e-010.516
90550MCUHTA11_3410_2000001011HumanColorectumAD1.98e-33-8.79e-010.0155
90550MCUHTA11_2951_2000001011HumanColorectumAD9.76e-04-8.53e-010.0216
90550MCUHTA11_347_2000001011HumanColorectumAD6.87e-156.61e-01-0.1954
90550MCUHTA11_3361_2000001011HumanColorectumAD7.02e-03-4.41e-01-0.1207
90550MCUHTA11_866_3004761011HumanColorectumAD1.66e-09-6.12e-010.096
90550MCUHTA11_8622_2000001021HumanColorectumSER4.25e-07-7.33e-010.0528
90550MCUHTA11_7696_3000711011HumanColorectumAD1.41e-07-4.49e-010.0674
90550MCUHTA11_6818_2000001011HumanColorectumAD2.38e-03-4.77e-010.0112
90550MCUHTA11_99999970781_79442HumanColorectumMSS1.22e-18-5.64e-010.294
90550MCUHTA11_99999971662_82457HumanColorectumMSS6.16e-12-5.87e-010.3859
90550MCUHTA11_99999973899_84307HumanColorectumMSS2.22e-11-9.20e-010.2585
90550MCUHTA11_99999974143_84620HumanColorectumMSS6.44e-53-1.12e+000.3005
90550MCUF007HumanColorectumFAP3.20e-02-4.44e-010.1176
90550MCUA001-C-207HumanColorectumFAP1.38e-04-4.64e-010.1278
90550MCUA015-C-203HumanColorectumFAP7.03e-28-5.67e-01-0.1294
90550MCUA015-C-204HumanColorectumFAP1.28e-07-4.91e-01-0.0228
90550MCUA014-C-040HumanColorectumFAP2.32e-10-8.95e-01-0.1184
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:005122216EndometriumEECpositive regulation of protein transport66/2168303/187232.55e-071.09e-0566
GO:199054216EndometriumEECmitochondrial transmembrane transport31/2168102/187232.65e-071.11e-0531
GO:004259314EndometriumEECglucose homeostasis56/2168258/187232.26e-066.61e-0556
GO:003350014EndometriumEECcarbohydrate homeostasis56/2168259/187232.56e-067.39e-0556
GO:005090013EndometriumEECleukocyte migration67/2168369/187231.19e-041.59e-0367
GO:005070813EndometriumEECregulation of protein secretion50/2168268/187234.33e-044.51e-0350
GO:000268513EndometriumEECregulation of leukocyte migration41/2168210/187235.35e-045.38e-0341
GO:005156112EndometriumEECpositive regulation of mitochondrial calcium ion concentration6/216811/187236.59e-046.37e-036
GO:009752913EndometriumEECmyeloid leukocyte migration42/2168220/187237.42e-047.02e-0342
GO:006032613EndometriumEECcell chemotaxis55/2168310/187238.22e-047.63e-0355
GO:001082115EndometriumEECregulation of mitochondrion organization30/2168144/187239.67e-048.64e-0330
GO:003059513EndometriumEECleukocyte chemotaxis43/2168230/187231.01e-038.89e-0343
GO:003210313EndometriumEECpositive regulation of response to external stimulus71/2168427/187231.06e-039.18e-0371
GO:003202412EndometriumEECpositive regulation of insulin secretion19/216878/187231.19e-031.00e-0219
GO:000268813EndometriumEECregulation of leukocyte chemotaxis26/2168122/187231.45e-031.18e-0226
GO:000268713EndometriumEECpositive regulation of leukocyte migration28/2168135/187231.50e-031.21e-0228
GO:005156012EndometriumEECmitochondrial calcium ion homeostasis9/216826/187231.82e-031.41e-029
GO:005071412EndometriumEECpositive regulation of protein secretion28/2168137/187231.89e-031.45e-0228
GO:005079611EndometriumEECregulation of insulin secretion32/2168165/187232.30e-031.70e-0232
GO:005092112EndometriumEECpositive regulation of chemotaxis28/2168141/187232.94e-032.07e-0228
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0501220CervixCCParkinson disease102/1267266/84651.81e-211.47e-198.66e-20102
hsa0502018CervixCCPrion disease98/1267273/84652.64e-181.42e-168.42e-1798
hsa0501018CervixCCAlzheimer disease113/1267384/84659.67e-143.92e-122.32e-12113
hsa0502218CervixCCPathways of neurodegeneration - multiple diseases128/1267476/84652.87e-129.29e-115.50e-11128
hsa0501418CervixCCAmyotrophic lateral sclerosis103/1267364/84651.79e-114.47e-102.64e-10103
hsa0421810CervixCCCellular senescence49/1267156/84651.30e-071.63e-069.61e-0749
hsa0501716CervixCCSpinocerebellar ataxia35/1267143/84651.77e-037.21e-034.26e-0335
hsa046213CervixCCNOD-like receptor signaling pathway41/1267186/84655.90e-031.95e-021.15e-0241
hsa05012110CervixCCParkinson disease102/1267266/84651.81e-211.47e-198.66e-20102
hsa0502019CervixCCPrion disease98/1267273/84652.64e-181.42e-168.42e-1798
hsa0501019CervixCCAlzheimer disease113/1267384/84659.67e-143.92e-122.32e-12113
hsa0502219CervixCCPathways of neurodegeneration - multiple diseases128/1267476/84652.87e-129.29e-115.50e-11128
hsa0501419CervixCCAmyotrophic lateral sclerosis103/1267364/84651.79e-114.47e-102.64e-10103
hsa0421815CervixCCCellular senescence49/1267156/84651.30e-071.63e-069.61e-0749
hsa0501717CervixCCSpinocerebellar ataxia35/1267143/84651.77e-037.21e-034.26e-0335
hsa0462112CervixCCNOD-like receptor signaling pathway41/1267186/84655.90e-031.95e-021.15e-0241
hsa05012ColorectumADParkinson disease147/2092266/84652.53e-278.48e-255.41e-25147
hsa05010ColorectumADAlzheimer disease174/2092384/84651.82e-199.26e-185.91e-18174
hsa05020ColorectumADPrion disease133/2092273/84652.47e-188.29e-175.29e-17133
hsa05014ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MCUSNVMissense_Mutationnovelc.10G>Ap.Ala4Thrp.A4TQ8NE86protein_codingtolerated_low_confidence(0.61)benign(0.001)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
MCUSNVMissense_Mutationnovelc.730N>Ap.Ala244Thrp.A244TQ8NE86protein_codingdeleterious(0.05)possibly_damaging(0.771)TCGA-AA-A01K-01Colorectumcolon adenocarcinomaFemale>=65III/IVChemotherapyfolinicCR
MCUSNVMissense_Mutationnovelc.494G>Tp.Arg165Ilep.R165IQ8NE86protein_codingdeleterious(0.04)benign(0.246)TCGA-AZ-4315-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
MCUSNVMissense_Mutationrs760003771c.721G>Ap.Ala241Thrp.A241TQ8NE86protein_codingdeleterious(0)probably_damaging(0.978)TCGA-CK-5916-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownPD
MCUSNVMissense_Mutationrs770146478c.857N>Ap.Arg286Hisp.R286HQ8NE86protein_codingdeleterious(0)possibly_damaging(0.883)TCGA-AG-A002-01Colorectumrectum adenocarcinomaMale<65I/IIUnknownUnknownSD
MCUinsertionFrame_Shift_Insnovelc.952_953insTATGTp.Asn318IlefsTer19p.N318Ifs*19Q8NE86protein_codingTCGA-AM-5820-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
MCUSNVMissense_Mutationnovelc.767N>Tp.Trp256Leup.W256LQ8NE86protein_codingdeleterious(0)probably_damaging(0.968)TCGA-A5-A0G2-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVUnknownUnknownSD
MCUSNVMissense_Mutationc.884N>Tp.Arg295Ilep.R295IQ8NE86protein_codingdeleterious(0)possibly_damaging(0.756)TCGA-AP-A0LM-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapycisplatinSD
MCUSNVMissense_Mutationc.376N>Ap.Ala126Thrp.A126TQ8NE86protein_codingtolerated(0.13)benign(0.135)TCGA-AX-A05S-01Endometriumuterine corpus endometrioid carcinomaFemale>=65III/IVUnspecificCarboplatin & PaclitaxelPD
MCUSNVMissense_Mutationnovelc.424N>Tp.Asp142Tyrp.D142YQ8NE86protein_codingdeleterious(0)benign(0.403)TCGA-AX-A05Z-01Endometriumuterine corpus endometrioid carcinomaFemale<65III/IVChemotherapyadriamycinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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