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Gene: MAPRE1 |
Gene summary for MAPRE1 |
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Gene information | Species | Human | Gene symbol | MAPRE1 | Gene ID | 22919 |
Gene name | microtubule associated protein RP/EB family member 1 | |
Gene Alias | EB1 | |
Cytomap | 20q11.21 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q15691 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22919 | MAPRE1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.12e-05 | 2.85e-01 | -0.0811 |
22919 | MAPRE1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.73e-02 | 2.19e-01 | -0.1088 |
22919 | MAPRE1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.66e-03 | 2.13e-01 | -0.1954 |
22919 | MAPRE1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.17e-04 | 2.74e-01 | -0.059 |
22919 | MAPRE1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.84e-06 | 2.44e-01 | 0.096 |
22919 | MAPRE1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.70e-10 | 4.35e-01 | 0.294 |
22919 | MAPRE1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.39e-11 | 5.86e-01 | 0.281 |
22919 | MAPRE1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.19e-26 | 7.39e-01 | 0.3859 |
22919 | MAPRE1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.16e-06 | 4.09e-01 | 0.2585 |
22919 | MAPRE1 | LZE4T | Human | Esophagus | ESCC | 6.05e-24 | 8.47e-01 | 0.0811 |
22919 | MAPRE1 | LZE7T | Human | Esophagus | ESCC | 3.32e-04 | 4.49e-01 | 0.0667 |
22919 | MAPRE1 | LZE8T | Human | Esophagus | ESCC | 3.02e-09 | 2.82e-01 | 0.067 |
22919 | MAPRE1 | LZE20T | Human | Esophagus | ESCC | 7.42e-06 | 1.15e-01 | 0.0662 |
22919 | MAPRE1 | LZE24T | Human | Esophagus | ESCC | 1.39e-28 | 1.21e+00 | 0.0596 |
22919 | MAPRE1 | LZE6T | Human | Esophagus | ESCC | 1.19e-05 | 4.41e-01 | 0.0845 |
22919 | MAPRE1 | P1T-E | Human | Esophagus | ESCC | 4.15e-02 | 4.90e-01 | 0.0875 |
22919 | MAPRE1 | P2T-E | Human | Esophagus | ESCC | 1.76e-38 | 8.53e-01 | 0.1177 |
22919 | MAPRE1 | P4T-E | Human | Esophagus | ESCC | 1.33e-28 | 7.06e-01 | 0.1323 |
22919 | MAPRE1 | P5T-E | Human | Esophagus | ESCC | 4.52e-34 | 7.45e-01 | 0.1327 |
22919 | MAPRE1 | P8T-E | Human | Esophagus | ESCC | 4.08e-26 | 7.36e-01 | 0.0889 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003111315 | Skin | cSCC | regulation of microtubule polymerization | 23/4864 | 55/18723 | 7.54e-03 | 3.53e-02 | 23 |
GO:19055087 | Skin | cSCC | protein localization to microtubule organizing center | 16/4864 | 35/18723 | 9.09e-03 | 4.16e-02 | 16 |
GO:005109828 | Thyroid | HT | regulation of binding | 56/1272 | 363/18723 | 6.41e-09 | 5.75e-07 | 56 |
GO:005109928 | Thyroid | HT | positive regulation of binding | 34/1272 | 173/18723 | 1.64e-08 | 1.30e-06 | 34 |
GO:190290330 | Thyroid | HT | regulation of supramolecular fiber organization | 47/1272 | 383/18723 | 6.02e-05 | 1.13e-03 | 47 |
GO:003133327 | Thyroid | HT | negative regulation of protein-containing complex assembly | 23/1272 | 141/18723 | 7.64e-05 | 1.37e-03 | 23 |
GO:004325430 | Thyroid | HT | regulation of protein-containing complex assembly | 50/1272 | 428/18723 | 1.24e-04 | 2.00e-03 | 50 |
GO:001063925 | Thyroid | HT | negative regulation of organelle organization | 39/1272 | 348/18723 | 1.45e-03 | 1.36e-02 | 39 |
GO:005125828 | Thyroid | HT | protein polymerization | 34/1272 | 297/18723 | 1.99e-03 | 1.77e-02 | 34 |
GO:190290528 | Thyroid | HT | positive regulation of supramolecular fiber organization | 26/1272 | 209/18723 | 2.06e-03 | 1.82e-02 | 26 |
GO:190290420 | Thyroid | HT | negative regulation of supramolecular fiber organization | 22/1272 | 167/18723 | 2.14e-03 | 1.87e-02 | 22 |
GO:00512258 | Thyroid | HT | spindle assembly | 17/1272 | 117/18723 | 2.34e-03 | 2.00e-02 | 17 |
GO:003111310 | Thyroid | HT | regulation of microtubule polymerization | 10/1272 | 55/18723 | 3.57e-03 | 2.73e-02 | 10 |
GO:004339326 | Thyroid | HT | regulation of protein binding | 24/1272 | 196/18723 | 3.67e-03 | 2.75e-02 | 24 |
GO:003227128 | Thyroid | HT | regulation of protein polymerization | 27/1272 | 233/18723 | 4.64e-03 | 3.28e-02 | 27 |
GO:003209219 | Thyroid | HT | positive regulation of protein binding | 13/1272 | 85/18723 | 4.69e-03 | 3.28e-02 | 13 |
GO:007050710 | Thyroid | HT | regulation of microtubule cytoskeleton organization | 19/1272 | 148/18723 | 5.50e-03 | 3.62e-02 | 19 |
GO:003133427 | Thyroid | HT | positive regulation of protein-containing complex assembly | 27/1272 | 237/18723 | 5.82e-03 | 3.74e-02 | 27 |
GO:000705110 | Thyroid | HT | spindle organization | 22/1272 | 184/18723 | 6.95e-03 | 4.22e-02 | 22 |
GO:0051098113 | Thyroid | PTC | regulation of binding | 195/5968 | 363/18723 | 3.21e-18 | 3.37e-16 | 195 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAPRE1 | SNV | Missense_Mutation | novel | c.556G>A | p.Val186Met | p.V186M | Q15691 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-A2-A3XW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamyicin | CR |
MAPRE1 | SNV | Missense_Mutation | novel | c.776N>A | p.Gly259Glu | p.G259E | Q15691 | protein_coding | tolerated(0.59) | probably_damaging(0.994) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MAPRE1 | SNV | Missense_Mutation | c.257G>A | p.Gly86Asp | p.G86D | Q15691 | protein_coding | deleterious(0.04) | benign(0.041) | TCGA-F4-6809-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
MAPRE1 | SNV | Missense_Mutation | c.93T>G | p.Asn31Lys | p.N31K | Q15691 | protein_coding | deleterious(0.02) | possibly_damaging(0.56) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
MAPRE1 | SNV | Missense_Mutation | rs770912318 | c.260T>C | p.Val87Ala | p.V87A | Q15691 | protein_coding | deleterious(0.01) | possibly_damaging(0.75) | TCGA-A5-A0VQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD |
MAPRE1 | SNV | Missense_Mutation | novel | c.365A>C | p.Lys122Thr | p.K122T | Q15691 | protein_coding | tolerated(0.08) | benign(0.119) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAPRE1 | SNV | Missense_Mutation | c.28N>A | p.Val10Met | p.V10M | Q15691 | protein_coding | tolerated(0.12) | possibly_damaging(0.756) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAPRE1 | SNV | Missense_Mutation | rs771324465 | c.604N>A | p.Val202Ile | p.V202I | Q15691 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAPRE1 | SNV | Missense_Mutation | novel | c.802T>C | p.Tyr268His | p.Y268H | Q15691 | protein_coding | deleterious(0.03) | possibly_damaging(0.543) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
MAPRE1 | SNV | Missense_Mutation | novel | c.266A>C | p.Lys89Thr | p.K89T | Q15691 | protein_coding | deleterious(0.02) | probably_damaging(0.936) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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