Tissue | Expression Dynamics | Abbreviation |
Cervix | | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:006161417 | Oral cavity | OSCC | pri-miRNA transcription by RNA polymerase II | 35/7305 | 55/18723 | 1.88e-04 | 1.27e-03 | 35 |
GO:190289317 | Oral cavity | OSCC | regulation of pri-miRNA transcription by RNA polymerase II | 34/7305 | 54/18723 | 3.12e-04 | 1.94e-03 | 34 |
GO:00422464 | Oral cavity | OSCC | tissue regeneration | 42/7305 | 72/18723 | 6.89e-04 | 3.84e-03 | 42 |
GO:19028958 | Oral cavity | OSCC | positive regulation of pri-miRNA transcription by RNA polymerase II | 26/7305 | 42/18723 | 2.22e-03 | 1.00e-02 | 26 |
GO:00605378 | Oral cavity | OSCC | muscle tissue development | 185/7305 | 403/18723 | 2.60e-03 | 1.14e-02 | 185 |
GO:00434034 | Oral cavity | OSCC | skeletal muscle tissue regeneration | 23/7305 | 37/18723 | 3.66e-03 | 1.51e-02 | 23 |
GO:00426927 | Oral cavity | OSCC | muscle cell differentiation | 175/7305 | 384/18723 | 4.79e-03 | 1.92e-02 | 175 |
GO:00147067 | Oral cavity | OSCC | striated muscle tissue development | 174/7305 | 384/18723 | 6.45e-03 | 2.40e-02 | 174 |
GO:00605762 | Oral cavity | OSCC | intestinal epithelial cell development | 10/7305 | 14/18723 | 1.44e-02 | 4.69e-02 | 10 |
GO:003109916 | Oral cavity | LP | regeneration | 76/4623 | 198/18723 | 1.25e-05 | 2.24e-04 | 76 |
GO:190165317 | Oral cavity | LP | cellular response to peptide | 122/4623 | 359/18723 | 4.22e-05 | 6.10e-04 | 122 |
GO:006049116 | Oral cavity | LP | regulation of cell projection assembly | 66/4623 | 188/18723 | 8.62e-04 | 7.49e-03 | 66 |
GO:00422461 | Oral cavity | LP | tissue regeneration | 30/4623 | 72/18723 | 1.13e-03 | 9.27e-03 | 30 |
GO:004340311 | Oral cavity | LP | skeletal muscle tissue regeneration | 18/4623 | 37/18723 | 1.36e-03 | 1.08e-02 | 18 |
GO:006161418 | Oral cavity | LP | pri-miRNA transcription by RNA polymerase II | 24/4623 | 55/18723 | 1.61e-03 | 1.24e-02 | 24 |
GO:012003217 | Oral cavity | LP | regulation of plasma membrane bounded cell projection assembly | 64/4623 | 186/18723 | 1.81e-03 | 1.37e-02 | 64 |
GO:190289516 | Oral cavity | LP | positive regulation of pri-miRNA transcription by RNA polymerase II | 19/4623 | 42/18723 | 2.92e-03 | 2.02e-02 | 19 |
GO:190289318 | Oral cavity | LP | regulation of pri-miRNA transcription by RNA polymerase II | 23/4623 | 54/18723 | 2.93e-03 | 2.02e-02 | 23 |
GO:190165323 | Oral cavity | EOLP | cellular response to peptide | 85/2218 | 359/18723 | 2.06e-10 | 2.06e-08 | 85 |
GO:003109923 | Oral cavity | EOLP | regeneration | 50/2218 | 198/18723 | 1.30e-07 | 4.25e-06 | 50 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
KLF5 | MES | Cervix | CC | ZFP36L1,CTNND1,MPZL2, etc. | 7.07e-01 | |
KLF5 | KER | Esophagus | Healthy | CLDN1,FAM46A,VIM, etc. | 2.01e-01 | |
KLF5 | STM | Esophagus | Healthy | CLDN1,FAM46A,VIM, etc. | 4.45e-01 | |
KLF5 | DUCT1 | Pancreas | PDAC | LMO7,TM9SF3,CYP3A5, etc. | 6.34e-01 | |
KLF5 | CD8TRM | Pancreas | ADJ | MOB3A,FAM160A1,IL3RA, etc. | 0.00e+00 | |
KLF5 | CD8TEREX | Pancreas | ADJ | MOB3A,FAM160A1,IL3RA, etc. | 5.23e-03 | |
KLF5 | CD8TCM | Pancreas | ADJ | MOB3A,FAM160A1,IL3RA, etc. | 2.22e-16 | |
KLF5 | TREG | Pancreas | ADJ | MOB3A,FAM160A1,IL3RA, etc. | 2.22e-16 | |
KLF5 | CD8TEREX | Pancreas | Healthy | MOB3A,FAM160A1,IL3RA, etc. | 0.00e+00 | |
KLF5 | TREG | Pancreas | Healthy | MOB3A,FAM160A1,IL3RA, etc. | 0.00e+00 | |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLF5 | deletion | Frame_Shift_Del | novel | c.280delN | p.Lys94SerfsTer3 | p.K94Sfs*3 | Q13887 | protein_coding | | | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD |
KLF5 | SNV | Missense_Mutation | | c.1255G>A | p.Glu419Lys | p.E419K | Q13887 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KLF5 | SNV | Missense_Mutation | | c.604N>A | p.Glu202Lys | p.E202K | Q13887 | protein_coding | tolerated(0.78) | benign(0) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
KLF5 | SNV | Missense_Mutation | | c.1255N>A | p.Glu419Lys | p.E419K | Q13887 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
KLF5 | SNV | Missense_Mutation | | c.341G>T | p.Arg114Leu | p.R114L | Q13887 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KLF5 | SNV | Missense_Mutation | | c.1255N>A | p.Glu419Lys | p.E419K | Q13887 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KLF5 | SNV | Missense_Mutation | | c.1255N>A | p.Glu419Lys | p.E419K | Q13887 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
KLF5 | SNV | Missense_Mutation | novel | c.1256N>G | p.Glu419Gly | p.E419G | Q13887 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A959-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
KLF5 | SNV | Missense_Mutation | | c.1255N>A | p.Glu419Lys | p.E419K | Q13887 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-VS-A9UC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
KLF5 | deletion | Frame_Shift_Del | novel | c.282_288delGTATCTG | p.Tyr95HisfsTer9 | p.Y95Hfs*9 | Q13887 | protein_coding | | | TCGA-JW-A5VK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |