Tissue | Expression Dynamics | Abbreviation |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | | BPH: Benign Prostatic Hyperplasia |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0001503110 | Thyroid | PTC | ossification | 176/5968 | 408/18723 | 9.26e-07 | 1.40e-05 | 176 |
GO:0048511111 | Thyroid | PTC | rhythmic process | 131/5968 | 298/18723 | 7.06e-06 | 8.33e-05 | 131 |
GO:0007623111 | Thyroid | PTC | circadian rhythm | 96/5968 | 210/18723 | 1.74e-05 | 1.82e-04 | 96 |
GO:0030099113 | Thyroid | PTC | myeloid cell differentiation | 160/5968 | 381/18723 | 1.75e-05 | 1.82e-04 | 160 |
GO:009872710 | Thyroid | PTC | maintenance of cell number | 63/5968 | 134/18723 | 1.73e-04 | 1.32e-03 | 63 |
GO:00198279 | Thyroid | PTC | stem cell population maintenance | 61/5968 | 131/18723 | 3.01e-04 | 2.12e-03 | 61 |
GO:000150324 | Thyroid | goiters | ossification | 25/497 | 408/18723 | 1.00e-04 | 3.16e-03 | 25 |
GO:00350192 | Thyroid | goiters | somatic stem cell population maintenance | 7/497 | 42/18723 | 1.07e-04 | 3.34e-03 | 7 |
GO:000276312 | Thyroid | goiters | positive regulation of myeloid leukocyte differentiation | 7/497 | 58/18723 | 8.30e-04 | 1.80e-02 | 7 |
GO:0045639110 | Thyroid | goiters | positive regulation of myeloid cell differentiation | 9/497 | 103/18723 | 1.68e-03 | 3.05e-02 | 9 |
GO:001982716 | Thyroid | goiters | stem cell population maintenance | 10/497 | 131/18723 | 2.61e-03 | 4.17e-02 | 10 |
GO:009872716 | Thyroid | goiters | maintenance of cell number | 10/497 | 134/18723 | 3.08e-03 | 4.69e-02 | 10 |
GO:0030099210 | Thyroid | goiters | myeloid cell differentiation | 20/497 | 381/18723 | 3.10e-03 | 4.70e-02 | 20 |
GO:000150332 | Thyroid | ATC | ossification | 206/6293 | 408/18723 | 9.23e-13 | 3.95e-11 | 206 |
GO:0071496210 | Thyroid | ATC | cellular response to external stimulus | 165/6293 | 320/18723 | 2.01e-11 | 7.23e-10 | 165 |
GO:190165325 | Thyroid | ATC | cellular response to peptide | 173/6293 | 359/18723 | 5.87e-09 | 1.28e-07 | 173 |
GO:003166927 | Thyroid | ATC | cellular response to nutrient levels | 112/6293 | 215/18723 | 1.57e-08 | 3.20e-07 | 112 |
GO:003166827 | Thyroid | ATC | cellular response to extracellular stimulus | 125/6293 | 246/18723 | 1.65e-08 | 3.31e-07 | 125 |
GO:004259424 | Thyroid | ATC | response to starvation | 103/6293 | 197/18723 | 4.59e-08 | 8.31e-07 | 103 |
GO:000926724 | Thyroid | ATC | cellular response to starvation | 85/6293 | 156/18723 | 6.14e-08 | 1.09e-06 | 85 |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
KLF10 | DC | Breast | ADJ | PABPC4,CD83,IRF2BP2, etc. | 4.95e-02 | |
KLF10 | INMON | Cervix | CC | CCL3L1,AZIN1-AS1,C15orf48, etc. | 1.98e-01 | |
KLF10 | MON | Cervix | CC | CCL3L1,AZIN1-AS1,C15orf48, etc. | 2.13e-01 | |
KLF10 | INMON | Cervix | HSIL_HPV | CCL3L1,AZIN1-AS1,C15orf48, etc. | 1.65e-01 | |
KLF10 | MAC | Colorectum | CRC | ZSCAN5A,FOXK2,BRD1, etc. | 3.32e-01 | |
KLF10 | MON | Colorectum | CRC | ZSCAN5A,FOXK2,BRD1, etc. | 2.70e-01 | |
KLF10 | MAC | Colorectum | Healthy | ZSCAN5A,FOXK2,BRD1, etc. | 4.38e-01 | |
KLF10 | MON | Colorectum | Healthy | ZSCAN5A,FOXK2,BRD1, etc. | 1.15e-01 | |
KLF10 | MAST | Endometrium | ADJ | MIIP,TJP2,MAPKAPK2, etc. | 1.02e-01 | |
KLF10 | MAST | Endometrium | EEC | MIIP,TJP2,MAPKAPK2, etc. | 7.73e-02 | |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLF10 | SNV | Missense_Mutation | rs749961016 | c.551N>A | p.Ser184Tyr | p.S184Y | Q13118 | protein_coding | tolerated(0.98) | benign(0.259) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KLF10 | SNV | Missense_Mutation | novel | c.442N>T | p.Pro148Ser | p.P148S | Q13118 | protein_coding | tolerated(0.23) | benign(0.015) | TCGA-BH-A0AV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
KLF10 | SNV | Missense_Mutation | novel | c.22N>G | p.Leu8Val | p.L8V | Q13118 | protein_coding | tolerated_low_confidence(0.07) | benign(0.014) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
KLF10 | insertion | In_Frame_Ins | novel | c.1054_1055insATCAAAACTTGGACCCTTGGAAAACAAAAGTTTTAATTA | p.Pro352delinsHisGlnAsnLeuAspProTrpLysThrLysValLeuIleThr | p.P352delinsHQNLDPWKTKVLIT | Q13118 | protein_coding | | | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
KLF10 | insertion | In_Frame_Ins | novel | c.578_579insCCCACACAG | p.Val193_Glu194insProHisSer | p.V193_E194insPHS | Q13118 | protein_coding | | | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLF10 | insertion | Frame_Shift_Ins | novel | c.577_578insACATTGCTCTACCTCCAACCCCTGC | p.Val193AspfsTer10 | p.V193Dfs*10 | Q13118 | protein_coding | | | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLF10 | insertion | Nonsense_Mutation | novel | c.1065_1066insTGAACTGAGTTCGCCCTCCC | p.Lys356Ter | p.K356* | Q13118 | protein_coding | | | TCGA-B6-A0RG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLF10 | insertion | Nonsense_Mutation | novel | c.60_61insTTCCAGTCAACATCGTGGATGTAGTGATTAA | p.Glu21PhefsTer8 | p.E21Ffs*8 | Q13118 | protein_coding | | | TCGA-BH-A0BA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
KLF10 | SNV | Missense_Mutation | novel | c.938N>T | p.Pro313Leu | p.P313L | Q13118 | protein_coding | deleterious(0) | possibly_damaging(0.665) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KLF10 | SNV | Missense_Mutation | novel | c.290N>A | p.Ser97Asn | p.S97N | Q13118 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |