Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: IPO5

Gene summary for IPO5

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

IPO5

Gene ID

3843

Gene nameimportin 5
Gene AliasIMB3
Cytomap13q32.2
Gene Typeprotein-coding
GO ID

GO:0000079

UniProtAcc

B3KWG6


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
3843IPO5HTA11_99999965104_69814HumanColorectumMSS5.05e-127.46e-010.281
3843IPO5HTA11_99999971662_82457HumanColorectumMSS6.95e-145.96e-010.3859
3843IPO5A015-C-203HumanColorectumFAP5.52e-05-1.27e-01-0.1294
3843IPO5A002-C-205HumanColorectumFAP3.12e-03-6.77e-02-0.1236
3843IPO5A002-C-114HumanColorectumFAP1.25e-04-2.00e-01-0.1561
3843IPO5A015-C-104HumanColorectumFAP5.58e-06-1.28e-01-0.1899
3843IPO5A002-C-016HumanColorectumFAP1.23e-06-1.25e-010.0521
3843IPO5A002-C-116HumanColorectumFAP2.10e-05-5.46e-02-0.0452
3843IPO5A018-E-020HumanColorectumFAP6.41e-03-1.24e-01-0.2034
3843IPO5F034HumanColorectumFAP1.78e-02-4.45e-02-0.0665
3843IPO5CRC-1-8810HumanColorectumCRC8.86e-083.09e-010.6257
3843IPO5LZE2THumanEsophagusESCC8.35e-074.21e-010.082
3843IPO5LZE4THumanEsophagusESCC5.38e-117.69e-020.0811
3843IPO5LZE5THumanEsophagusESCC2.80e-022.34e-010.0514
3843IPO5LZE7THumanEsophagusESCC4.45e-074.93e-010.0667
3843IPO5LZE8THumanEsophagusESCC9.93e-075.48e-020.067
3843IPO5LZE20THumanEsophagusESCC1.85e-03-1.77e-030.0662
3843IPO5LZE24THumanEsophagusESCC2.16e-141.90e-010.0596
3843IPO5P1T-EHumanEsophagusESCC7.18e-031.84e-010.0875
3843IPO5P2T-EHumanEsophagusESCC2.20e-193.29e-010.1177
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:190018210Oral cavityOSCCpositive regulation of protein localization to nucleus66/730587/187232.74e-121.10e-1066
GO:190018015Oral cavityOSCCregulation of protein localization to nucleus93/7305136/187233.46e-121.35e-1093
GO:004232619Oral cavityOSCCnegative regulation of phosphorylation214/7305385/187232.30e-117.74e-10214
GO:007190010Oral cavityOSCCregulation of protein serine/threonine kinase activity201/7305359/187233.90e-111.27e-09201
GO:000193319Oral cavityOSCCnegative regulation of protein phosphorylation191/7305342/187231.58e-104.62e-09191
GO:003367317Oral cavityOSCCnegative regulation of kinase activity140/7305237/187232.74e-107.57e-09140
GO:000646918Oral cavityOSCCnegative regulation of protein kinase activity127/7305212/187235.21e-101.37e-08127
GO:00511709Oral cavityOSCCimport into nucleus100/7305159/187238.67e-102.15e-08100
GO:00066069Oral cavityOSCCprotein import into nucleus97/7305155/187232.27e-095.30e-0897
GO:00457864Oral cavityOSCCnegative regulation of cell cycle206/7305385/187234.28e-099.55e-08206
GO:004682414Oral cavityOSCCpositive regulation of nucleocytoplasmic transport45/730562/187238.26e-081.46e-0645
GO:19045899Oral cavityOSCCregulation of protein import43/730563/187232.43e-063.06e-0543
GO:00719013Oral cavityOSCCnegative regulation of protein serine/threonine kinase activity72/7305120/187232.53e-063.17e-0572
GO:19040293Oral cavityOSCCregulation of cyclin-dependent protein kinase activity60/730598/187236.90e-067.56e-0560
GO:00000793Oral cavityOSCCregulation of cyclin-dependent protein serine/threonine kinase activity58/730594/187236.92e-067.57e-0558
GO:19045918Oral cavityOSCCpositive regulation of protein import31/730543/187231.10e-051.14e-0431
GO:00423068Oral cavityOSCCregulation of protein import into nucleus40/730560/187231.32e-051.33e-0440
GO:00423078Oral cavityOSCCpositive regulation of protein import into nucleus29/730541/187233.81e-053.37e-0429
GO:00011019Oral cavityOSCCresponse to acid chemical74/7305135/187231.38e-049.76e-0474
GO:00432006Oral cavityOSCCresponse to amino acid64/7305116/187232.96e-041.86e-0364
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0301321EsophagusESCCNucleocytoplasmic transport89/4205108/84651.20e-122.37e-111.21e-1189
hsa0301331EsophagusESCCNucleocytoplasmic transport89/4205108/84651.20e-122.37e-111.21e-1189
hsa03013LiverHCCNucleocytoplasmic transport81/4020108/84654.28e-096.83e-083.80e-0881
hsa030131LiverHCCNucleocytoplasmic transport81/4020108/84654.28e-096.83e-083.80e-0881
hsa030136Oral cavityOSCCNucleocytoplasmic transport82/3704108/84657.93e-121.33e-106.77e-1182
hsa0301311Oral cavityOSCCNucleocytoplasmic transport82/3704108/84657.93e-121.33e-106.77e-1182
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
IPO5SNVMissense_Mutationrs9584741c.2731G>Ap.Glu911Lysp.E911KO00410protein_codingdeleterious(0)probably_damaging(0.994)TCGA-A2-A0EY-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinSD
IPO5SNVMissense_Mutationrs371777975c.1615N>Ap.Asp539Asnp.D539NO00410protein_codingtolerated(0.06)possibly_damaging(0.867)TCGA-A8-A08L-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
IPO5SNVMissense_Mutationc.3040T>Cp.Trp1014Argp.W1014RO00410protein_codingdeleterious(0)probably_damaging(0.996)TCGA-GI-A2C8-01Breastbreast invasive carcinomaFemale<65III/IVUnspecificAdriamycinSD
IPO5SNVMissense_Mutationnovelc.780N>Cp.Glu260Aspp.E260DO00410protein_codingtolerated(0.99)benign(0.14)TCGA-LL-A740-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinCR
IPO5SNVMissense_Mutationnovelc.1470C>Ap.Asp490Glup.D490EO00410protein_codingtolerated(0.22)possibly_damaging(0.517)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
IPO5SNVMissense_Mutationc.28N>Ap.Glu10Lysp.E10KO00410protein_codingdeleterious_low_confidence(0)probably_damaging(0.953)TCGA-C5-A1BE-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinPD
IPO5SNVMissense_Mutationc.1295G>Cp.Arg432Thrp.R432TO00410protein_codingdeleterious(0)probably_damaging(0.999)TCGA-C5-A1MK-01Cervixcervical & endocervical cancerFemale>=65III/IVChemotherapycarboplatinPD
IPO5SNVMissense_Mutationc.1145T>Cp.Met382Thrp.M382TO00410protein_codingtolerated(0.1)benign(0.089)TCGA-EX-A69M-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownPD
IPO5SNVMissense_Mutationnovelc.1958N>Tp.Ser653Leup.S653LO00410protein_codingdeleterious(0)possibly_damaging(0.543)TCGA-JW-A5VL-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
IPO5SNVMissense_Mutationrs566255473c.1688N>Tp.Ala563Valp.A563VO00410protein_codingdeleterious(0.03)possibly_damaging(0.758)TCGA-A6-2672-01Colorectumcolon adenocarcinomaFemale>=65III/IVUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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