![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: INAVA |
Gene summary for INAVA |
![]() |
Gene information | Species | Human | Gene symbol | INAVA | Gene ID | 55765 |
Gene name | innate immunity activator | |
Gene Alias | C1orf106 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q3KP66 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55765 | INAVA | CCI_1 | Human | Cervix | CC | 8.10e-05 | 6.70e-01 | 0.528 |
55765 | INAVA | CCI_3 | Human | Cervix | CC | 4.32e-09 | 6.41e-01 | 0.516 |
55765 | INAVA | sample3 | Human | Cervix | CC | 1.71e-19 | 3.59e-01 | 0.1387 |
55765 | INAVA | T3 | Human | Cervix | CC | 1.72e-12 | 3.36e-01 | 0.1389 |
55765 | INAVA | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.41e-02 | 1.89e-01 | 0.0155 |
55765 | INAVA | HTA11_2487_2000001011 | Human | Colorectum | SER | 8.32e-24 | 1.03e+00 | -0.1808 |
55765 | INAVA | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.25e-17 | 7.42e-01 | -0.0811 |
55765 | INAVA | HTA11_78_2000001011 | Human | Colorectum | AD | 1.24e-08 | 5.68e-01 | -0.1088 |
55765 | INAVA | HTA11_347_2000001011 | Human | Colorectum | AD | 9.32e-36 | 9.01e-01 | -0.1954 |
55765 | INAVA | HTA11_411_2000001011 | Human | Colorectum | SER | 1.87e-10 | 1.54e+00 | -0.2602 |
55765 | INAVA | HTA11_2112_2000001011 | Human | Colorectum | SER | 3.25e-13 | 1.23e+00 | -0.2196 |
55765 | INAVA | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.39e-12 | 7.05e-01 | -0.1207 |
55765 | INAVA | HTA11_83_2000001011 | Human | Colorectum | SER | 1.10e-09 | 6.37e-01 | -0.1526 |
55765 | INAVA | HTA11_696_2000001011 | Human | Colorectum | AD | 3.38e-23 | 8.29e-01 | -0.1464 |
55765 | INAVA | HTA11_866_2000001011 | Human | Colorectum | AD | 5.77e-16 | 6.29e-01 | -0.1001 |
55765 | INAVA | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.48e-13 | 6.87e-01 | -0.059 |
55765 | INAVA | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.58e-10 | 8.38e-01 | -0.1706 |
55765 | INAVA | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.70e-17 | 1.03e+00 | -0.2061 |
55765 | INAVA | HTA11_546_2000001011 | Human | Colorectum | AD | 1.20e-05 | 5.75e-01 | -0.0842 |
55765 | INAVA | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.55e-03 | 3.10e-01 | 0.0674 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00326522 | Stomach | CSG | regulation of interleukin-1 production | 17/1034 | 128/18723 | 6.80e-04 | 9.58e-03 | 17 |
GO:00027642 | Stomach | CSG | immune response-regulating signaling pathway | 43/1034 | 468/18723 | 7.58e-04 | 1.04e-02 | 43 |
GO:003052221 | Stomach | CSG | intracellular receptor signaling pathway | 28/1034 | 265/18723 | 7.73e-04 | 1.06e-02 | 28 |
GO:00018192 | Stomach | CSG | positive regulation of cytokine production | 42/1034 | 467/18723 | 1.32e-03 | 1.56e-02 | 42 |
GO:00704312 | Stomach | CSG | nucleotide-binding oligomerization domain containing 2 signaling pathway | 5/1034 | 16/18723 | 1.33e-03 | 1.56e-02 | 5 |
GO:00027532 | Stomach | CSG | cytoplasmic pattern recognition receptor signaling pathway | 10/1034 | 60/18723 | 1.53e-03 | 1.72e-02 | 10 |
GO:00704232 | Stomach | CSG | nucleotide-binding oligomerization domain containing signaling pathway | 6/1034 | 25/18723 | 2.00e-03 | 2.08e-02 | 6 |
GO:00358722 | Stomach | CSG | nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway | 6/1034 | 26/18723 | 2.48e-03 | 2.45e-02 | 6 |
GO:19034092 | Stomach | CSG | reactive oxygen species biosynthetic process | 10/1034 | 64/18723 | 2.52e-03 | 2.46e-02 | 10 |
GO:003433121 | Stomach | CSG | cell junction maintenance | 7/1034 | 35/18723 | 2.65e-03 | 2.55e-02 | 7 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |