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Gene: EEF1D |
Gene summary for EEF1D |
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Gene information | Species | Human | Gene symbol | EEF1D | Gene ID | 1936 |
Gene name | eukaryotic translation elongation factor 1 delta | |
Gene Alias | EF-1D | |
Cytomap | 8q24.3 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | B2RAR6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1936 | EEF1D | GSM4909277 | Human | Breast | Precancer | 7.82e-05 | -8.65e-01 | 0.0177 |
1936 | EEF1D | GSM4909280 | Human | Breast | Precancer | 2.09e-07 | -7.64e-01 | 0.0305 |
1936 | EEF1D | GSM4909281 | Human | Breast | IDC | 1.18e-06 | 1.92e-01 | 0.21 |
1936 | EEF1D | GSM4909282 | Human | Breast | IDC | 2.80e-02 | -1.05e-01 | -0.0288 |
1936 | EEF1D | GSM4909293 | Human | Breast | IDC | 2.83e-26 | -2.39e-01 | 0.1581 |
1936 | EEF1D | GSM4909294 | Human | Breast | IDC | 4.34e-18 | 1.11e-01 | 0.2022 |
1936 | EEF1D | GSM4909296 | Human | Breast | IDC | 2.82e-19 | 1.79e-01 | 0.1524 |
1936 | EEF1D | GSM4909297 | Human | Breast | IDC | 3.35e-34 | 1.12e-01 | 0.1517 |
1936 | EEF1D | GSM4909298 | Human | Breast | IDC | 4.57e-03 | -8.56e-02 | 0.1551 |
1936 | EEF1D | GSM4909302 | Human | Breast | IDC | 1.31e-24 | 2.21e-01 | 0.1545 |
1936 | EEF1D | GSM4909304 | Human | Breast | IDC | 4.40e-09 | 2.25e-01 | 0.1636 |
1936 | EEF1D | GSM4909305 | Human | Breast | IDC | 2.35e-15 | 2.65e-01 | 0.0436 |
1936 | EEF1D | GSM4909306 | Human | Breast | IDC | 2.96e-37 | 3.43e-01 | 0.1564 |
1936 | EEF1D | GSM4909307 | Human | Breast | IDC | 4.89e-12 | 1.99e-01 | 0.1569 |
1936 | EEF1D | GSM4909308 | Human | Breast | IDC | 9.76e-20 | 2.59e-01 | 0.158 |
1936 | EEF1D | GSM4909309 | Human | Breast | IDC | 5.92e-27 | 2.18e-01 | 0.0483 |
1936 | EEF1D | GSM4909311 | Human | Breast | IDC | 5.79e-79 | 4.08e-01 | 0.1534 |
1936 | EEF1D | GSM4909312 | Human | Breast | IDC | 2.01e-94 | 5.35e-01 | 0.1552 |
1936 | EEF1D | GSM4909313 | Human | Breast | IDC | 2.17e-11 | 7.08e-02 | 0.0391 |
1936 | EEF1D | GSM4909315 | Human | Breast | IDC | 3.53e-22 | -5.07e-01 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00712141 | Stomach | CAG with IM | cellular response to abiotic stimulus | 31/1050 | 331/18723 | 3.66e-03 | 3.26e-02 | 31 |
GO:01040041 | Stomach | CAG with IM | cellular response to environmental stimulus | 31/1050 | 331/18723 | 3.66e-03 | 3.26e-02 | 31 |
GO:0010212 | Stomach | CAG with IM | response to ionizing radiation | 17/1050 | 148/18723 | 3.91e-03 | 3.42e-02 | 17 |
GO:004312221 | Stomach | CSG | regulation of I-kappaB kinase/NF-kappaB signaling | 29/1034 | 249/18723 | 1.21e-04 | 2.58e-03 | 29 |
GO:000724921 | Stomach | CSG | I-kappaB kinase/NF-kappaB signaling | 30/1034 | 281/18723 | 4.30e-04 | 6.76e-03 | 30 |
GO:00093142 | Stomach | CSG | response to radiation | 43/1034 | 456/18723 | 4.45e-04 | 6.98e-03 | 43 |
GO:004312321 | Stomach | CSG | positive regulation of I-kappaB kinase/NF-kappaB signaling | 22/1034 | 186/18723 | 6.21e-04 | 9.00e-03 | 22 |
GO:00712142 | Stomach | CSG | cellular response to abiotic stimulus | 31/1034 | 331/18723 | 2.92e-03 | 2.74e-02 | 31 |
GO:01040042 | Stomach | CSG | cellular response to environmental stimulus | 31/1034 | 331/18723 | 2.92e-03 | 2.74e-02 | 31 |
GO:00714792 | Stomach | CSG | cellular response to ionizing radiation | 10/1034 | 72/18723 | 6.01e-03 | 4.70e-02 | 10 |
GO:00093143 | Stomach | CAG | response to radiation | 31/552 | 456/18723 | 1.53e-05 | 5.84e-04 | 31 |
GO:00064144 | Stomach | CAG | translational elongation | 7/552 | 55/18723 | 1.11e-03 | 1.51e-02 | 7 |
GO:0071478 | Stomach | CAG | cellular response to radiation | 13/552 | 186/18723 | 3.57e-03 | 3.34e-02 | 13 |
GO:00102121 | Stomach | CAG | response to ionizing radiation | 11/552 | 148/18723 | 4.48e-03 | 4.00e-02 | 11 |
GO:00714793 | Stomach | CAG | cellular response to ionizing radiation | 7/552 | 72/18723 | 5.25e-03 | 4.43e-02 | 7 |
GO:00093144 | Stomach | WIM | response to radiation | 26/426 | 456/18723 | 1.84e-05 | 7.44e-04 | 26 |
GO:00714794 | Stomach | WIM | cellular response to ionizing radiation | 7/426 | 72/18723 | 1.24e-03 | 1.74e-02 | 7 |
GO:00102122 | Stomach | WIM | response to ionizing radiation | 10/426 | 148/18723 | 2.10e-03 | 2.54e-02 | 10 |
GO:00714781 | Stomach | WIM | cellular response to radiation | 11/426 | 186/18723 | 3.64e-03 | 3.60e-02 | 11 |
GO:00712143 | Stomach | WIM | cellular response to abiotic stimulus | 16/426 | 331/18723 | 3.96e-03 | 3.84e-02 | 16 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EEF1D | SNV | Missense_Mutation | c.1591G>A | p.Glu531Lys | p.E531K | P29692 | protein_coding | deleterious(0.03) | probably_damaging(0.954) | TCGA-BH-A0C1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
EEF1D | SNV | Missense_Mutation | novel | c.73N>T | p.Arg25Trp | p.R25W | P29692 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
EEF1D | SNV | Missense_Mutation | rs200146410 | c.1637G>A | p.Arg546Gln | p.R546Q | P29692 | protein_coding | tolerated(0.07) | benign(0.305) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
EEF1D | SNV | Missense_Mutation | c.1520N>A | p.Pro507Gln | p.P507Q | P29692 | protein_coding | deleterious(0.03) | benign(0.017) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
EEF1D | SNV | Missense_Mutation | rs751524072 | c.688C>T | p.Arg230Trp | p.R230W | P29692 | protein_coding | deleterious(0.01) | possibly_damaging(0.446) | TCGA-CA-5256-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR |
EEF1D | SNV | Missense_Mutation | c.1282G>A | p.Ala428Thr | p.A428T | P29692 | protein_coding | deleterious(0.02) | probably_damaging(0.974) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
EEF1D | deletion | In_Frame_Del | rs532050197 | c.827_844delNNNNNNNNNNNNNNNNNN | p.Arg276_Arg281del | p.R276_R281del | P29692 | protein_coding | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | ||
EEF1D | deletion | Frame_Shift_Del | c.260delA | p.Lys87ArgfsTer73 | p.K87Rfs*73 | P29692 | protein_coding | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
EEF1D | deletion | In_Frame_Del | c.1873_1875delCTG | p.Leu625del | p.L625del | P29692 | protein_coding | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
EEF1D | SNV | Missense_Mutation | novel | c.1159N>A | p.Ala387Thr | p.A387T | P29692 | protein_coding | deleterious(0.01) | probably_damaging(0.969) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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