![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CYRIB |
Gene summary for CYRIB |
![]() |
Gene information | Species | Human | Gene symbol | CYRIB | Gene ID | 51571 |
Gene name | CYFIP related Rac1 interactor B | |
Gene Alias | BM-009 | |
Cytomap | 8q24.21 | |
Gene Type | protein-coding | GO ID | GO:0000266 | UniProtAcc | A0A024R9G4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51571 | CYRIB | CA_HPV_1 | Human | Cervix | CC | 2.84e-03 | 1.84e-01 | 0.0264 |
51571 | CYRIB | N_HPV_2 | Human | Cervix | N_HPV | 3.16e-03 | 1.85e-01 | -0.0131 |
51571 | CYRIB | CCI_1 | Human | Cervix | CC | 1.93e-06 | -5.20e-01 | 0.528 |
51571 | CYRIB | CCI_2 | Human | Cervix | CC | 8.18e-06 | -5.20e-01 | 0.5249 |
51571 | CYRIB | CCI_3 | Human | Cervix | CC | 5.72e-09 | -5.20e-01 | 0.516 |
51571 | CYRIB | CCII_1 | Human | Cervix | CC | 7.66e-13 | -5.20e-01 | 0.3249 |
51571 | CYRIB | Tumor | Human | Cervix | CC | 6.17e-26 | -5.20e-01 | 0.1241 |
51571 | CYRIB | sample1 | Human | Cervix | CC | 1.45e-10 | -5.20e-01 | 0.0959 |
51571 | CYRIB | sample3 | Human | Cervix | CC | 2.98e-28 | -5.20e-01 | 0.1387 |
51571 | CYRIB | H2 | Human | Cervix | HSIL_HPV | 2.98e-28 | -5.20e-01 | 0.0632 |
51571 | CYRIB | L1 | Human | Cervix | CC | 3.46e-14 | -5.20e-01 | 0.0802 |
51571 | CYRIB | T1 | Human | Cervix | CC | 5.04e-24 | -5.20e-01 | 0.0918 |
51571 | CYRIB | T2 | Human | Cervix | CC | 1.97e-05 | -5.20e-01 | 0.0709 |
51571 | CYRIB | T3 | Human | Cervix | CC | 4.34e-27 | -5.20e-01 | 0.1389 |
51571 | CYRIB | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.85e-17 | 3.24e-01 | 0.0155 |
51571 | CYRIB | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.28e-26 | 6.02e-01 | -0.1808 |
51571 | CYRIB | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.22e-05 | 3.08e-01 | 0.0216 |
51571 | CYRIB | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.66e-36 | 8.32e-01 | -0.0811 |
51571 | CYRIB | HTA11_78_2000001011 | Human | Colorectum | AD | 2.21e-33 | 8.00e-01 | -0.1088 |
51571 | CYRIB | HTA11_347_2000001011 | Human | Colorectum | AD | 1.60e-53 | 8.72e-01 | -0.1954 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00308331 | Colorectum | SER | regulation of actin filament polymerization | 64/2897 | 172/18723 | 2.42e-12 | 5.70e-10 | 64 |
GO:00329701 | Colorectum | SER | regulation of actin filament-based process | 115/2897 | 397/18723 | 4.16e-12 | 8.80e-10 | 115 |
GO:00322711 | Colorectum | SER | regulation of protein polymerization | 78/2897 | 233/18723 | 5.71e-12 | 1.17e-09 | 78 |
GO:00512581 | Colorectum | SER | protein polymerization | 91/2897 | 297/18723 | 2.72e-11 | 5.06e-09 | 91 |
GO:00432541 | Colorectum | SER | regulation of protein-containing complex assembly | 119/2897 | 428/18723 | 3.34e-11 | 5.86e-09 | 119 |
GO:00329561 | Colorectum | SER | regulation of actin cytoskeleton organization | 104/2897 | 358/18723 | 3.68e-11 | 6.11e-09 | 104 |
GO:00108211 | Colorectum | SER | regulation of mitochondrion organization | 48/2897 | 144/18723 | 7.51e-08 | 4.70e-06 | 48 |
GO:00106391 | Colorectum | SER | negative regulation of organelle organization | 90/2897 | 348/18723 | 3.14e-07 | 1.69e-05 | 90 |
GO:00322721 | Colorectum | SER | negative regulation of protein polymerization | 31/2897 | 80/18723 | 3.67e-07 | 1.96e-05 | 31 |
GO:00308371 | Colorectum | SER | negative regulation of actin filament polymerization | 27/2897 | 65/18723 | 4.00e-07 | 2.06e-05 | 27 |
GO:19029041 | Colorectum | SER | negative regulation of supramolecular fiber organization | 50/2897 | 167/18723 | 1.63e-06 | 7.23e-05 | 50 |
GO:00071631 | Colorectum | SER | establishment or maintenance of cell polarity | 60/2897 | 218/18723 | 3.45e-06 | 1.33e-04 | 60 |
GO:00514941 | Colorectum | SER | negative regulation of cytoskeleton organization | 48/2897 | 163/18723 | 4.34e-06 | 1.63e-04 | 48 |
GO:00313331 | Colorectum | SER | negative regulation of protein-containing complex assembly | 43/2897 | 141/18723 | 5.03e-06 | 1.86e-04 | 43 |
GO:00328781 | Colorectum | SER | regulation of establishment or maintenance of cell polarity | 11/2897 | 25/18723 | 6.43e-04 | 8.67e-03 | 11 |
GO:00457851 | Colorectum | SER | positive regulation of cell adhesion | 93/2897 | 437/18723 | 6.78e-04 | 9.04e-03 | 93 |
GO:20001141 | Colorectum | SER | regulation of establishment of cell polarity | 10/2897 | 22/18723 | 8.31e-04 | 1.02e-02 | 10 |
GO:00300101 | Colorectum | SER | establishment of cell polarity | 37/2897 | 143/18723 | 8.72e-04 | 1.06e-02 | 37 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |