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Gene: CDT1 |
Gene summary for CDT1 |
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Gene information | Species | Human | Gene symbol | CDT1 | Gene ID | 81620 |
Gene name | chromatin licensing and DNA replication factor 1 | |
Gene Alias | DUP | |
Cytomap | 16q24.3 | |
Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | Q9H211 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81620 | CDT1 | P1T-E | Human | Esophagus | ESCC | 9.99e-03 | 3.60e-01 | 0.0875 |
81620 | CDT1 | P2T-E | Human | Esophagus | ESCC | 3.24e-19 | 6.20e-01 | 0.1177 |
81620 | CDT1 | P4T-E | Human | Esophagus | ESCC | 1.83e-16 | 5.22e-01 | 0.1323 |
81620 | CDT1 | P5T-E | Human | Esophagus | ESCC | 1.73e-35 | 7.31e-01 | 0.1327 |
81620 | CDT1 | P8T-E | Human | Esophagus | ESCC | 1.21e-20 | 5.12e-01 | 0.0889 |
81620 | CDT1 | P10T-E | Human | Esophagus | ESCC | 2.57e-02 | 9.82e-02 | 0.116 |
81620 | CDT1 | P12T-E | Human | Esophagus | ESCC | 7.00e-03 | 1.58e-01 | 0.1122 |
81620 | CDT1 | P15T-E | Human | Esophagus | ESCC | 7.75e-12 | 4.68e-01 | 0.1149 |
81620 | CDT1 | P16T-E | Human | Esophagus | ESCC | 3.39e-05 | 2.49e-01 | 0.1153 |
81620 | CDT1 | P17T-E | Human | Esophagus | ESCC | 1.39e-07 | 6.93e-01 | 0.1278 |
81620 | CDT1 | P21T-E | Human | Esophagus | ESCC | 5.55e-07 | 2.02e-01 | 0.1617 |
81620 | CDT1 | P22T-E | Human | Esophagus | ESCC | 2.80e-07 | 2.81e-01 | 0.1236 |
81620 | CDT1 | P23T-E | Human | Esophagus | ESCC | 1.00e-07 | 4.10e-01 | 0.108 |
81620 | CDT1 | P24T-E | Human | Esophagus | ESCC | 4.01e-18 | 5.36e-01 | 0.1287 |
81620 | CDT1 | P26T-E | Human | Esophagus | ESCC | 1.60e-10 | 4.31e-01 | 0.1276 |
81620 | CDT1 | P27T-E | Human | Esophagus | ESCC | 3.93e-06 | 1.94e-01 | 0.1055 |
81620 | CDT1 | P28T-E | Human | Esophagus | ESCC | 3.86e-18 | 4.65e-01 | 0.1149 |
81620 | CDT1 | P31T-E | Human | Esophagus | ESCC | 1.41e-30 | 8.94e-01 | 0.1251 |
81620 | CDT1 | P32T-E | Human | Esophagus | ESCC | 1.94e-21 | 4.73e-01 | 0.1666 |
81620 | CDT1 | P37T-E | Human | Esophagus | ESCC | 2.77e-07 | 3.34e-01 | 0.1371 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00513061 | Oral cavity | OSCC | mitotic sister chromatid separation | 45/7305 | 67/18723 | 2.82e-06 | 3.47e-05 | 45 |
GO:00070911 | Oral cavity | OSCC | metaphase/anaphase transition of mitotic cell cycle | 42/7305 | 62/18723 | 4.30e-06 | 4.98e-05 | 42 |
GO:00900688 | Oral cavity | OSCC | positive regulation of cell cycle process | 126/7305 | 236/18723 | 4.75e-06 | 5.44e-05 | 126 |
GO:00330451 | Oral cavity | OSCC | regulation of sister chromatid segregation | 47/7305 | 72/18723 | 5.69e-06 | 6.33e-05 | 47 |
GO:19058181 | Oral cavity | OSCC | regulation of chromosome separation | 47/7305 | 72/18723 | 5.69e-06 | 6.33e-05 | 47 |
GO:200125216 | Oral cavity | OSCC | positive regulation of chromosome organization | 52/7305 | 82/18723 | 6.56e-06 | 7.24e-05 | 52 |
GO:00109651 | Oral cavity | OSCC | regulation of mitotic sister chromatid separation | 43/7305 | 65/18723 | 8.50e-06 | 9.06e-05 | 43 |
GO:00315704 | Oral cavity | OSCC | DNA integrity checkpoint | 72/7305 | 123/18723 | 8.77e-06 | 9.31e-05 | 72 |
GO:00300711 | Oral cavity | OSCC | regulation of mitotic metaphase/anaphase transition | 40/7305 | 60/18723 | 1.32e-05 | 1.33e-04 | 40 |
GO:00062611 | Oral cavity | OSCC | DNA-dependent DNA replication | 84/7305 | 151/18723 | 2.46e-05 | 2.30e-04 | 84 |
GO:00447841 | Oral cavity | OSCC | metaphase/anaphase transition of cell cycle | 42/7305 | 65/18723 | 2.57e-05 | 2.39e-04 | 42 |
GO:19019924 | Oral cavity | OSCC | positive regulation of mitotic cell cycle phase transition | 56/7305 | 93/18723 | 2.76e-05 | 2.56e-04 | 56 |
GO:0051783 | Oral cavity | OSCC | regulation of nuclear division | 78/7305 | 139/18723 | 3.13e-05 | 2.86e-04 | 78 |
GO:20012512 | Oral cavity | OSCC | negative regulation of chromosome organization | 52/7305 | 86/18723 | 4.50e-05 | 3.84e-04 | 52 |
GO:0006270 | Oral cavity | OSCC | DNA replication initiation | 25/7305 | 34/18723 | 4.63e-05 | 3.90e-04 | 25 |
GO:00062753 | Oral cavity | OSCC | regulation of DNA replication | 62/7305 | 107/18723 | 5.49e-05 | 4.54e-04 | 62 |
GO:19020991 | Oral cavity | OSCC | regulation of metaphase/anaphase transition of cell cycle | 40/7305 | 63/18723 | 7.19e-05 | 5.67e-04 | 40 |
GO:00458392 | Oral cavity | OSCC | negative regulation of mitotic nuclear division | 32/7305 | 48/18723 | 9.60e-05 | 7.25e-04 | 32 |
GO:19019895 | Oral cavity | OSCC | positive regulation of cell cycle phase transition | 65/7305 | 115/18723 | 1.03e-04 | 7.69e-04 | 65 |
GO:000974320 | Oral cavity | OSCC | response to carbohydrate | 128/7305 | 253/18723 | 1.11e-04 | 8.16e-04 | 128 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa041102 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa041103 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0411015 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CDT1 | SNV | Missense_Mutation | c.545C>A | p.Pro182Gln | p.P182Q | Q9H211 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CDT1 | SNV | Missense_Mutation | novel | c.1018G>T | p.Val340Leu | p.V340L | Q9H211 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-E2-A574-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
CDT1 | SNV | Missense_Mutation | novel | c.468G>T | p.Glu156Asp | p.E156D | Q9H211 | protein_coding | tolerated(0.13) | benign(0.007) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CDT1 | SNV | Missense_Mutation | novel | c.466N>A | p.Glu156Lys | p.E156K | Q9H211 | protein_coding | tolerated(0.35) | benign(0.007) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
CDT1 | SNV | Missense_Mutation | novel | c.466G>A | p.Glu156Lys | p.E156K | Q9H211 | protein_coding | tolerated(0.35) | benign(0.007) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CDT1 | SNV | Missense_Mutation | novel | c.641C>A | p.Pro214His | p.P214H | Q9H211 | protein_coding | deleterious(0) | possibly_damaging(0.882) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CDT1 | SNV | Missense_Mutation | c.1621C>T | p.Arg541Cys | p.R541C | Q9H211 | protein_coding | deleterious(0.02) | possibly_damaging(0.676) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
CDT1 | SNV | Missense_Mutation | novel | c.310N>A | p.Ala104Thr | p.A104T | Q9H211 | protein_coding | tolerated(0.32) | benign(0.039) | TCGA-AP-A0LS-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CDT1 | SNV | Missense_Mutation | novel | c.1118C>T | p.Pro373Leu | p.P373L | Q9H211 | protein_coding | deleterious(0) | probably_damaging(0.948) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CDT1 | SNV | Missense_Mutation | novel | c.1065G>T | p.Glu355Asp | p.E355D | Q9H211 | protein_coding | tolerated(0.47) | benign(0.07) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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