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Gene: BUB3 |
Gene summary for BUB3 |
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Gene information | Species | Human | Gene symbol | BUB3 | Gene ID | 9184 |
Gene name | BUB3 mitotic checkpoint protein | |
Gene Alias | BUB3L | |
Cytomap | 10q26.13 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A140VJF3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9184 | BUB3 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.60e-10 | 5.19e-01 | 0.294 |
9184 | BUB3 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.62e-02 | 2.79e-01 | 0.281 |
9184 | BUB3 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.72e-02 | 3.34e-01 | 0.3859 |
9184 | BUB3 | LZE4T | Human | Esophagus | ESCC | 1.04e-11 | 5.92e-01 | 0.0811 |
9184 | BUB3 | LZE7T | Human | Esophagus | ESCC | 4.71e-04 | 4.80e-01 | 0.0667 |
9184 | BUB3 | LZE8T | Human | Esophagus | ESCC | 4.54e-07 | 3.53e-01 | 0.067 |
9184 | BUB3 | LZE20T | Human | Esophagus | ESCC | 1.69e-03 | 2.16e-01 | 0.0662 |
9184 | BUB3 | LZE22D1 | Human | Esophagus | HGIN | 4.96e-05 | 8.64e-02 | 0.0595 |
9184 | BUB3 | LZE22T | Human | Esophagus | ESCC | 3.33e-04 | 1.84e-01 | 0.068 |
9184 | BUB3 | LZE24T | Human | Esophagus | ESCC | 3.42e-21 | 7.19e-01 | 0.0596 |
9184 | BUB3 | LZE21T | Human | Esophagus | ESCC | 4.95e-02 | 3.46e-01 | 0.0655 |
9184 | BUB3 | LZE6T | Human | Esophagus | ESCC | 5.20e-12 | 7.97e-01 | 0.0845 |
9184 | BUB3 | P1T-E | Human | Esophagus | ESCC | 1.14e-03 | 4.93e-01 | 0.0875 |
9184 | BUB3 | P2T-E | Human | Esophagus | ESCC | 1.26e-58 | 1.27e+00 | 0.1177 |
9184 | BUB3 | P4T-E | Human | Esophagus | ESCC | 3.79e-41 | 1.24e+00 | 0.1323 |
9184 | BUB3 | P5T-E | Human | Esophagus | ESCC | 1.36e-58 | 1.46e+00 | 0.1327 |
9184 | BUB3 | P8T-E | Human | Esophagus | ESCC | 1.67e-21 | 5.48e-01 | 0.0889 |
9184 | BUB3 | P9T-E | Human | Esophagus | ESCC | 1.09e-08 | 5.08e-01 | 0.1131 |
9184 | BUB3 | P10T-E | Human | Esophagus | ESCC | 4.35e-30 | 7.36e-01 | 0.116 |
9184 | BUB3 | P11T-E | Human | Esophagus | ESCC | 8.45e-19 | 9.87e-01 | 0.1426 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00482854 | Skin | cSCC | organelle fission | 197/4864 | 488/18723 | 1.51e-12 | 8.36e-11 | 197 |
GO:009881311 | Skin | cSCC | nuclear chromosome segregation | 126/4864 | 281/18723 | 4.76e-12 | 2.53e-10 | 126 |
GO:00002803 | Skin | cSCC | nuclear division | 178/4864 | 439/18723 | 1.17e-11 | 5.93e-10 | 178 |
GO:190199014 | Skin | cSCC | regulation of mitotic cell cycle phase transition | 128/4864 | 299/18723 | 1.48e-10 | 6.56e-09 | 128 |
GO:00519834 | Skin | cSCC | regulation of chromosome segregation | 52/4864 | 91/18723 | 2.88e-10 | 1.20e-08 | 52 |
GO:0010639111 | Skin | cSCC | negative regulation of organelle organization | 140/4864 | 348/18723 | 3.35e-09 | 1.15e-07 | 140 |
GO:00070913 | Skin | cSCC | metaphase/anaphase transition of mitotic cell cycle | 37/4864 | 62/18723 | 2.13e-08 | 6.11e-07 | 37 |
GO:00330453 | Skin | cSCC | regulation of sister chromatid segregation | 41/4864 | 72/18723 | 2.48e-08 | 6.89e-07 | 41 |
GO:19058183 | Skin | cSCC | regulation of chromosome separation | 41/4864 | 72/18723 | 2.48e-08 | 6.89e-07 | 41 |
GO:00300713 | Skin | cSCC | regulation of mitotic metaphase/anaphase transition | 36/4864 | 60/18723 | 2.71e-08 | 7.41e-07 | 36 |
GO:00109653 | Skin | cSCC | regulation of mitotic sister chromatid separation | 38/4864 | 65/18723 | 3.03e-08 | 8.18e-07 | 38 |
GO:190198714 | Skin | cSCC | regulation of cell cycle phase transition | 150/4864 | 390/18723 | 3.21e-08 | 8.61e-07 | 150 |
GO:00070884 | Skin | cSCC | regulation of mitotic nuclear division | 55/4864 | 110/18723 | 5.62e-08 | 1.44e-06 | 55 |
GO:00513063 | Skin | cSCC | mitotic sister chromatid separation | 38/4864 | 67/18723 | 9.27e-08 | 2.22e-06 | 38 |
GO:00447843 | Skin | cSCC | metaphase/anaphase transition of cell cycle | 37/4864 | 65/18723 | 1.20e-07 | 2.79e-06 | 37 |
GO:19020993 | Skin | cSCC | regulation of metaphase/anaphase transition of cell cycle | 36/4864 | 63/18723 | 1.55e-07 | 3.51e-06 | 36 |
GO:00086082 | Skin | cSCC | attachment of spindle microtubules to kinetochore | 24/4864 | 35/18723 | 1.56e-07 | 3.51e-06 | 24 |
GO:00517832 | Skin | cSCC | regulation of nuclear division | 64/4864 | 139/18723 | 2.49e-07 | 5.25e-06 | 64 |
GO:20012514 | Skin | cSCC | negative regulation of chromosome organization | 43/4864 | 86/18723 | 1.53e-06 | 2.61e-05 | 43 |
GO:190199114 | Skin | cSCC | negative regulation of mitotic cell cycle phase transition | 75/4864 | 179/18723 | 2.38e-06 | 3.84e-05 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa051662 | Colorectum | MSS | Human T-cell leukemia virus 1 infection | 68/1875 | 222/8465 | 1.84e-03 | 9.61e-03 | 5.89e-03 | 68 |
hsa051663 | Colorectum | MSS | Human T-cell leukemia virus 1 infection | 68/1875 | 222/8465 | 1.84e-03 | 9.61e-03 | 5.89e-03 | 68 |
hsa0516639 | Esophagus | HGIN | Human T-cell leukemia virus 1 infection | 51/1383 | 222/8465 | 5.84e-03 | 4.05e-02 | 3.22e-02 | 51 |
hsa041109 | Esophagus | HGIN | Cell cycle | 38/1383 | 157/8465 | 6.70e-03 | 4.37e-02 | 3.47e-02 | 38 |
hsa05166114 | Esophagus | HGIN | Human T-cell leukemia virus 1 infection | 51/1383 | 222/8465 | 5.84e-03 | 4.05e-02 | 3.22e-02 | 51 |
hsa0411016 | Esophagus | HGIN | Cell cycle | 38/1383 | 157/8465 | 6.70e-03 | 4.37e-02 | 3.47e-02 | 38 |
hsa0411023 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa05166211 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0411033 | Esophagus | ESCC | Cell cycle | 126/4205 | 157/8465 | 1.34e-15 | 5.60e-14 | 2.87e-14 | 126 |
hsa05166310 | Esophagus | ESCC | Human T-cell leukemia virus 1 infection | 164/4205 | 222/8465 | 8.13e-14 | 2.09e-12 | 1.07e-12 | 164 |
hsa0516614 | Liver | Cirrhotic | Human T-cell leukemia virus 1 infection | 87/2530 | 222/8465 | 1.69e-03 | 8.01e-03 | 4.94e-03 | 87 |
hsa041104 | Liver | Cirrhotic | Cell cycle | 61/2530 | 157/8465 | 9.53e-03 | 3.21e-02 | 1.98e-02 | 61 |
hsa0516615 | Liver | Cirrhotic | Human T-cell leukemia virus 1 infection | 87/2530 | 222/8465 | 1.69e-03 | 8.01e-03 | 4.94e-03 | 87 |
hsa0411011 | Liver | Cirrhotic | Cell cycle | 61/2530 | 157/8465 | 9.53e-03 | 3.21e-02 | 1.98e-02 | 61 |
hsa041102 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa0516622 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa041103 | Liver | HCC | Cell cycle | 106/4020 | 157/8465 | 2.54e-07 | 3.04e-06 | 1.69e-06 | 106 |
hsa0516632 | Liver | HCC | Human T-cell leukemia virus 1 infection | 139/4020 | 222/8465 | 3.17e-06 | 2.79e-05 | 1.55e-05 | 139 |
hsa041108 | Oral cavity | OSCC | Cell cycle | 118/3704 | 157/8465 | 7.15e-16 | 2.66e-14 | 1.35e-14 | 118 |
hsa0516630 | Oral cavity | OSCC | Human T-cell leukemia virus 1 infection | 150/3704 | 222/8465 | 3.68e-13 | 7.26e-12 | 3.70e-12 | 150 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BUB3 | SNV | Missense_Mutation | novel | c.358G>C | p.Val120Leu | p.V120L | O43684 | protein_coding | tolerated(0.56) | benign(0.052) | TCGA-A2-A3XX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
BUB3 | SNV | Missense_Mutation | c.637G>A | p.Glu213Lys | p.E213K | O43684 | protein_coding | deleterious(0.02) | possibly_damaging(0.835) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
BUB3 | SNV | Missense_Mutation | c.548G>A | p.Arg183His | p.R183H | O43684 | protein_coding | deleterious(0) | possibly_damaging(0.503) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
BUB3 | SNV | Missense_Mutation | c.169G>C | p.Gly57Arg | p.G57R | O43684 | protein_coding | tolerated(0.13) | benign(0.001) | TCGA-GM-A2DD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR | |
BUB3 | SNV | Missense_Mutation | novel | c.715G>A | p.Ala239Thr | p.A239T | O43684 | protein_coding | tolerated(0.05) | possibly_damaging(0.606) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
BUB3 | SNV | Missense_Mutation | c.506N>G | p.Tyr169Cys | p.Y169C | O43684 | protein_coding | tolerated(0.18) | possibly_damaging(0.598) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BUB3 | SNV | Missense_Mutation | c.550N>C | p.Cys184Arg | p.C184R | O43684 | protein_coding | tolerated(0.06) | possibly_damaging(0.736) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BUB3 | SNV | Missense_Mutation | c.548N>A | p.Arg183His | p.R183H | O43684 | protein_coding | deleterious(0) | possibly_damaging(0.503) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
BUB3 | insertion | In_Frame_Ins | novel | c.196_197insGGC | p.Asp66delinsGlyHis | p.D66delinsGH | O43684 | protein_coding | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
BUB3 | insertion | Frame_Shift_Ins | novel | c.690_691insGGTAA | p.Ile231GlyfsTer30 | p.I231Gfs*30 | O43684 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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